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Diagnostics
Volume 11
Issue 3
10.3390/diagnostics11030423
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Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression

by
Lena M. Mittlmeier
1,†,
Stephan T. Ledderose
2,†,
Melanie Schott
3,
Matthias Brendel
1,
Leonie Beyer
1,
Sebastian Theurich
4,
Doris Mayr
2,
Christoph Walz
2,
Wolfgang G. Kunz
5,
Jens Ricke
5,
Peter Bartenstein
1,
Harun Ilhan
1,
Michael Staehler
3 and
Marcus Unterrainer
5,*
1
Department of Nuclear Medicine, University Hospital, LMU Munich, 81377 Munich, Germany
2
Institute of Pathology, LMU Munich, 81377 Munich, Germany
3
Department of Urology, University Hospital, LMU Munich, 81377 Munich, Germany
4
Department of Medicine III, University Hospital, LMU Munich, 81377 Munich, Germany
5
Department of Radiology, University Hospital, LMU Munich, 81377 Munich, Germany
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2021, 11(3), 423; https://doi.org/10.3390/diagnostics11030423
Submission received: 11 February 2021 / Revised: 28 February 2021 / Accepted: 1 March 2021 / Published: 3 March 2021
(This article belongs to the Section Medical Imaging and Theranostics)
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Abstract

We present a 71-year-old female patient who underwent 18F-PSMA-1007 PET/CT for suspected metastatic renal cell carcinoma (RCC), as RCC also shows high PSMA-expression in tumor neovascularization. 18F-PSMA-1007 PET/CT showed a high PSMA-avidity in the renal tumor, enlarged intra-abdominal and mediastinal lymph nodes. Moreover, PSMA-positive pleural, pulmonal and osseous lesions were found. However, histopathology revealed an immature plasma cell myeloma with an endothelial PSMA-expression of the neovasculature. This case illustrates the increased PSMA-avidity in multiple myeloma and highlights PSMA as a potential theragnostic target in multiple myeloma. For clinical routine, lymphatic diseases such as extramedullary myeloma should be considered as differential diagnosis in PSMA-avid renal masses on PET/CT.
Keywords: renal cell carcinoma; 18F-PSMA PET/CT; myeloma renal cell carcinoma; 18F-PSMA PET/CT; myeloma

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MDPI and ACS Style

Mittlmeier, L.M.; Ledderose, S.T.; Schott, M.; Brendel, M.; Beyer, L.; Theurich, S.; Mayr, D.; Walz, C.; Kunz, W.G.; Ricke, J.; et al. Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression. Diagnostics 2021, 11, 423. https://doi.org/10.3390/diagnostics11030423

AMA Style

Mittlmeier LM, Ledderose ST, Schott M, Brendel M, Beyer L, Theurich S, Mayr D, Walz C, Kunz WG, Ricke J, et al. Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression. Diagnostics. 2021; 11(3):423. https://doi.org/10.3390/diagnostics11030423

Chicago/Turabian Style

Mittlmeier, Lena M., Stephan T. Ledderose, Melanie Schott, Matthias Brendel, Leonie Beyer, Sebastian Theurich, Doris Mayr, Christoph Walz, Wolfgang G. Kunz, Jens Ricke, and et al. 2021. "Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression" Diagnostics 11, no. 3: 423. https://doi.org/10.3390/diagnostics11030423

APA Style

Mittlmeier, L. M., Ledderose, S. T., Schott, M., Brendel, M., Beyer, L., Theurich, S., Mayr, D., Walz, C., Kunz, W. G., Ricke, J., Bartenstein, P., Ilhan, H., Staehler, M., & Unterrainer, M. (2021). Immature Plasma Cell Myeloma Mimics Metastatic Renal Cell Carcinoma on 18F-PSMA-1007 PET/CT Due to Endothelial PSMA-Expression. Diagnostics, 11(3), 423. https://doi.org/10.3390/diagnostics11030423

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