Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patient Data
2.2. Dermoscopic and Clinical Image Acquisition
2.3. Autofluorescence and Diffuse Reflectance Imaging with Narrow-Band LED Excitation
2.4. Statistical Analysis
3. Results
3.1. Clinical Presentation and Histopathological Features
3.2. Dermoscopy Images
3.3. Autofluorescence and Diffuse Reflectance Imaging
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Pt. No. | Sex | Age (y) | Phenodex Score |
---|---|---|---|
1 | F | 53 | S3 E3 G0 V1 C0 R0 |
2 | F | 53 | S2 E3 G0 V1 C1 R0 |
3 | M | 69 | S3 E3 G0 V0 C0 R0 |
4 | M | 52 | S2 E3 G0 V0 C1 R0 |
5 | F | 48 | S2 E2 G0 V0 C0 R0 |
Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 | |
---|---|---|---|---|---|
neck | + | + | + | + | + |
axilla | + | (+) | + | + | (+) |
antecubital fossa | + | (+) | + | (+) | + |
popliteal fossa | + | (+) | + | (+) | (+) |
inguinal | + | + | + | (+) | |
periumbilical | + | + | |||
wrist | + | (+) | |||
chest | (+) |
Structure | Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 | |
---|---|---|---|---|---|---|
neck | globules | plaques | dots, linear | mesh network | linear | dots, plaques |
background | red | brownish | purple-red | red | brownish | |
vessels | reticulated, linear | reticulated | reticulated | reticulated | no | |
axilla | globules | plaques | dots | mesh network | dots | dots |
background | purple | brownish | purple-red | pink | brownish | |
vessels | linear | no | reticulated | no | no | |
antecubital fossa | globules | linear | (non-typical) | linear | linear | plaque |
background | purple-red | purple | brownish | purple | ||
vessels | reticulated | reticulated | no | no | ||
popliteal fossa | globules | linear | linear | linear | dots | linear |
background | purple-red | brownish | purple | pink | purple | |
vessels | several reticulated | no | reticulated | reticulated | reticulated | |
inguinal | globules | dots | (non-typical) | (non-typical) | (non-typical) | |
background | purple | |||||
vessels | reticulated | |||||
periumbilical | globules | dots | (absent) | |||
background | purple-red | |||||
vessels | reticulated | |||||
wrist | globules | plaques | (absent) | |||
background | purple | |||||
vessels | reticulated | |||||
chest | globules | (absent) | ||||
background | ||||||
vessels |
Pt 1 | Pt 2 | Pt 3 | Pt 4 | Pt 5 | |
---|---|---|---|---|---|
Site 1 | popliteal fossa | popliteal fossa | popliteal fossa | popliteal fossa | periumbilical |
Site 2 | Inguinal | inguinal | inguinal | axilla | inguinal |
Site 3 | periumbilical | axilla | inguinal | axilla | axilla |
Site 4 | axilla | axilla | axilla | axilla | antecubital fossa |
Site 5 | wrist | antecubital fossa | antecubital fossa | wrist | antecubital fossa |
Site 6 | antecubital fossa | neck | neck | antecubital fossa | neck |
Site 7 | neck | neck | neck | neck | neck |
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Farkas, K.; Bozsányi, S.; Plázár, D.; Bánvölgyi, A.; Fésűs, L.; Anker, P.; Zakariás, S.; Lihacova, I.; Lihachev, A.; Lange, M.; et al. Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum. Diagnostics 2021, 11, 260. https://doi.org/10.3390/diagnostics11020260
Farkas K, Bozsányi S, Plázár D, Bánvölgyi A, Fésűs L, Anker P, Zakariás S, Lihacova I, Lihachev A, Lange M, et al. Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum. Diagnostics. 2021; 11(2):260. https://doi.org/10.3390/diagnostics11020260
Chicago/Turabian StyleFarkas, Klára, Szabolcs Bozsányi, Dóra Plázár, András Bánvölgyi, Luca Fésűs, Pálma Anker, Sára Zakariás, Ilze Lihacova, Alexey Lihachev, Marta Lange, and et al. 2021. "Autofluorescence Imaging of the Skin Is an Objective Non-Invasive Technique for Diagnosing Pseudoxanthoma Elasticum" Diagnostics 11, no. 2: 260. https://doi.org/10.3390/diagnostics11020260