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Review

Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies

1
Centro de Investigación Biomédica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170147, Ecuador
2
Immunology and Virology Laboratory, Department of Life Science and Agriculture, Universidad de las Fuerzas Armadas, Quito 171103, Ecuador
3
Grupo de Investigación en Biotecnología Aplicada a Biomedicina (BIOMED), Universidad de Las Américas, Quito 170125, Ecuador
4
One Health Research Group, Faculty of Medicine, Universidad de Las Américas (UDLA), Quito 170125, Ecuador
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Institute for Bioengineering, School of Engineering, University of Edinburgh, Edinburgh EH8 9LE, UK
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Centre for Synthetic and Systems Biology (SynthSys), University of Edinburgh, Edinburgh EH8 9LE, UK
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Experimental Medicine Research Unit, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City 4510, Mexico
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Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito 170147, Ecuador
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Escuela de Medicina, Colegio de Ciencias de la Salud Quito, Universidad San Francisco de Quito USFQ, Quito 170901, Ecuador
*
Author to whom correspondence should be addressed.
Academic Editor: Anna Baraniak
Diagnostics 2021, 11(11), 1981; https://doi.org/10.3390/diagnostics11111981
Received: 14 July 2021 / Revised: 18 September 2021 / Accepted: 23 September 2021 / Published: 26 October 2021
The COVID-19 pandemic has had an enormous impact on economies and health systems globally, therefore a top priority is the development of increasingly better diagnostic and surveillance alternatives to slow down the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In order to establish massive testing and contact tracing policies, it is crucial to have a clear view of the diagnostic options available and their principal advantages and drawbacks. Although classical molecular methods such as RT-qPCR are broadly used, diagnostic alternatives based on technologies such as LAMP, antigen, serological testing, or the application of novel technologies such as CRISPR-Cas for diagnostics, are also discussed. The present review also discusses the most important automation strategies employed to increase testing capability. Several serological-based diagnostic kits are presented, as well as novel nanotechnology-based diagnostic methods. In summary, this review provides a clear diagnostic landscape of the most relevant tools to track COVID-19. View Full-Text
Keywords: COVID-19; nucleic acid amplification test; antigen testing; CRISPR-based diagnostics; nanotechnology-based diagnostics; automation COVID-19; nucleic acid amplification test; antigen testing; CRISPR-based diagnostics; nanotechnology-based diagnostics; automation
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MDPI and ACS Style

Guaman-Bautista, L.P.; Moreta-Urbano, E.; Oña-Arias, C.G.; Torres-Arias, M.; Kyriakidis, N.C.; Malcı, K.; Jonguitud-Borrego, N.; Rios-Solis, L.; Ramos-Martinez, E.; López-Cortés, A.; Barba-Ostria, C. Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies. Diagnostics 2021, 11, 1981. https://doi.org/10.3390/diagnostics11111981

AMA Style

Guaman-Bautista LP, Moreta-Urbano E, Oña-Arias CG, Torres-Arias M, Kyriakidis NC, Malcı K, Jonguitud-Borrego N, Rios-Solis L, Ramos-Martinez E, López-Cortés A, Barba-Ostria C. Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies. Diagnostics. 2021; 11(11):1981. https://doi.org/10.3390/diagnostics11111981

Chicago/Turabian Style

Guaman-Bautista, Linda P., Erick Moreta-Urbano, Claudia G. Oña-Arias, Marbel Torres-Arias, Nikolaos C. Kyriakidis, Koray Malcı, Nestor Jonguitud-Borrego, Leonardo Rios-Solis, Espiridion Ramos-Martinez, Andrés López-Cortés, and Carlos Barba-Ostria. 2021. "Tracking SARS-CoV-2: Novel Trends and Diagnostic Strategies" Diagnostics 11, no. 11: 1981. https://doi.org/10.3390/diagnostics11111981

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