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Article

Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus

1
Department of Structures, Construction and Graphical Expression, Technical University of Cartagena, 30202 Cartagena, Spain
2
Group of Optics and Visual Perception, Department of Optics, Pharmacology and Anatomy, University of Alicante, 03690 Alicante, Spain
3
Doctorate Program in Industrial Technologies, International School of Doctorate, Technical University of Cartagena, 30202 Cartagena, Spain
4
Department of Research and Development, VISSUM, 03016 Alicante, Spain
5
Cornea, Cataract and Refractive Surgery Department, VISSUM, 03016 Alicante, Spain
6
Division of Ophthalmology, Department of Pathology and Surgery, Faculty of Medicine, Miguel Hernández University, 03202 Alicante, Spain
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(9), 640; https://doi.org/10.3390/diagnostics10090640
Received: 5 August 2020 / Revised: 25 August 2020 / Accepted: 25 August 2020 / Published: 27 August 2020
(This article belongs to the Special Issue Corneal and Retinal Diseases: Diagnostic and Therapeutic Approaches)
The morphogeometric analysis of the corneal structure has become a clinically relevant diagnostic procedure in keratoconus (KC) as well as the in vivo evaluation of the corneal biomechanical properties. However, the relationship between these two types of metrics is still not well understood. The current study investigated the relationship of corneal morphogeometry and volume with two biomechanical parameters: corneal hysteresis (CH) and corneal resistance factor (CRF), both provided by an Ocular Response Analyzer (Reichert). It included 109 eyes from 109 patients (aged between 18 and 69 years) with a diagnosis of keratoconus (KC) who underwent a complete eye examination including a comprehensive corneal topographic analysis with the Sirius system (CSO). With the topographic information obtained, a morphogeometric and volumetric analysis was performed, defining different variables of clinical use. CH and CRF were found to be correlated with these variables, but this correlation was highly influenced by corneal thickness. This suggests that the mechanical properties of KC cornea contribute only in a partial and limited manner to these biomechanical parameters, being mostly influenced by morphogeometry under normal intraocular pressure levels. This would explain the limitation of CH and CRF as diagnostic tools for the detection of incipient cases of KC. View Full-Text
Keywords: keratoconus; corneal hysteresis; corneal biomechanics; corneal volume; corneal morphogeometry keratoconus; corneal hysteresis; corneal biomechanics; corneal volume; corneal morphogeometry
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MDPI and ACS Style

Cavas, F.; Piñero, D.; Velázquez, J.S.; Mira, J.; Alió, J.L. Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus. Diagnostics 2020, 10, 640. https://doi.org/10.3390/diagnostics10090640

AMA Style

Cavas F, Piñero D, Velázquez JS, Mira J, Alió JL. Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus. Diagnostics. 2020; 10(9):640. https://doi.org/10.3390/diagnostics10090640

Chicago/Turabian Style

Cavas, Francisco; Piñero, David; Velázquez, José S.; Mira, Jorge; Alió, Jorge L. 2020. "Relationship between Corneal Morphogeometrical Properties and Biomechanical Parameters Derived from Dynamic Bidirectional Air Applanation Measurement Procedure in Keratoconus" Diagnostics 10, no. 9: 640. https://doi.org/10.3390/diagnostics10090640

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