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Benefits and Risks of IgG Transplacental Transfer

Carol Davila University of Medicine and Pharmacy, Bucharest 020021, Romania
Filantropia Clinical Hospital, Bucharest 11171, Romania
Author to whom correspondence should be addressed.
These authors are equally contributed to this work.
Diagnostics 2020, 10(8), 583;
Received: 1 July 2020 / Revised: 7 August 2020 / Accepted: 10 August 2020 / Published: 12 August 2020
(This article belongs to the Special Issue Fetal Medicine)
Maternal passage of immunoglobulin G (IgG) is an important passive mechanism for protecting the infant while the neonatal immune system is still immature and ineffective. IgG is the only antibody class capable of crossing the histological layers of the placenta by attaching to the neonatal Fc receptor expressed at the level of syncytiotrophoblasts, and it offers protection against neonatal infectious pathogens. In pregnant women with autoimmune or alloimmune disorders, or in those requiring certain types of biological therapy, transplacental passage of abnormal antibodies may cause fetal or neonatal harm. In this review, we will discuss the physiological mechanisms and benefits of transplacental transfer of maternal antibodies as well as pathological maternal situations where this system is hijacked, potentially leading to adverse neonatal outcomes. View Full-Text
Keywords: immunoglobulin G; pregnancy; vaccine; transplacental transfer; autoimmune disorders; alloimmune disorders immunoglobulin G; pregnancy; vaccine; transplacental transfer; autoimmune disorders; alloimmune disorders
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MDPI and ACS Style

Ciobanu, A.M.; Dumitru, A.E.; Gica, N.; Botezatu, R.; Peltecu, G.; Panaitescu, A.M. Benefits and Risks of IgG Transplacental Transfer. Diagnostics 2020, 10, 583.

AMA Style

Ciobanu AM, Dumitru AE, Gica N, Botezatu R, Peltecu G, Panaitescu AM. Benefits and Risks of IgG Transplacental Transfer. Diagnostics. 2020; 10(8):583.

Chicago/Turabian Style

Ciobanu, Anca M.; Dumitru, Andreea E.; Gica, Nicolae; Botezatu, Radu; Peltecu, Gheorghe; Panaitescu, Anca M. 2020. "Benefits and Risks of IgG Transplacental Transfer" Diagnostics 10, no. 8: 583.

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