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State-of-the-Art Technology of Model Organisms for Current Human Medicine

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Center of Medical Innovation and Translational Research, Osaka University Graduate School of Medicine, Suita, Yamadaoka 2-2, Osaka 565-0871, Japan
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Artificial Intelligence Research Center, The Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
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Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan
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Kyowa-kai Medical Corporation, Hyogo 666-0015, Japan
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Kinshu-kai Medical Corporation, Osaka 558-0041, Japan
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Prophoenix Division, Food and Life-Science Laboratory, Idea Consultants, Inc., Osaka-city, Osaka 559-8519, Japan
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Unitech Co., Ltd., Kashiwa 277-0005, Japan
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Hirotsu Bio Science Inc., Tokyo 107-0062, Japan
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Author to whom correspondence should be addressed.
Diagnostics 2020, 10(6), 392; https://doi.org/10.3390/diagnostics10060392
Received: 17 April 2020 / Revised: 27 May 2020 / Accepted: 9 June 2020 / Published: 10 June 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Since the 1980s, molecular biology has been used to investigate medical field mechanisms that still require the use of crude biological materials in order to achieve their necessary goals. Transcription factor-induced pluripotent stem cells are used in regenerative medicine to screen drugs and to support lost tissues. However, these cells insufficiently reconstruct whole organs and require various intact cells, such as damaged livers and diabetic pancreases. For efficient gene transfer in medical use, virally mediated gene transfers are used, although immunogenic issues are investigated. To obtain efficient detective and diagnostic power in intractable diseases, biological tools such as roundworms and zebrafish have been found to be useful for high-throughput screening (HST) and diagnosis. Taken together, this biological approach will help to fill the gaps between medical needs and novel innovations in the field of medicine. View Full-Text
Keywords: biology; diagnosis; therapy; regenerative medicine biology; diagnosis; therapy; regenerative medicine
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Konno, M.; Asai, A.; Kitagawa, T.; Yabumoto, M.; Ofusa, K.; Arai, T.; Hirotsu, T.; Doki, Y.; Eguchi, H.; Ishii, H. State-of-the-Art Technology of Model Organisms for Current Human Medicine. Diagnostics 2020, 10, 392.

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