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Open AccessArticle

Determination of Tear Lipid Film Thickness Based on a Reflected Placido Disk Tear Film Analyzer

1
Department of Ophthalmology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
2
Department of Laboratory Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Diagnostics 2020, 10(6), 353; https://doi.org/10.3390/diagnostics10060353
Received: 26 April 2020 / Revised: 24 May 2020 / Accepted: 25 May 2020 / Published: 28 May 2020
(This article belongs to the Special Issue Dry Eye and Ocular Surface Disorders)
This study aims at determining the thickness of the tear lipid layer (LL) observed from a placido-disc-based tear film analyzer. We prospectively collected reflections of placido-disk LL images using a tear film analyzer (Keratograph® 5M, Oculus) from subjects with dry eye symptoms. The LL thickness (LLT) over the inferior half of the cornea was estimated with the use of interference color analysis and the preprocessing of images with and without ring segmentation were obtained and analyzed. Moreover, LLTs before and after 1 h of applying topical ointment (Duratears, Alcon) were compared to validate the estimation of LLT. Our results suggested that the tear LLT can be assessed using a placido-disk-based tear film analyzer and interference color analysis. We verified a high correlation between non-segmented and segmented LL images and estimated LLT increase after applying ointment. In addition, we concluded that LLT can be evaluated by direct interference analysis without segmentation preprocessing. View Full-Text
Keywords: lipid layer thickness; tear film homeostasis; dry eye; meibomian gland dysfunction lipid layer thickness; tear film homeostasis; dry eye; meibomian gland dysfunction
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MDPI and ACS Style

Fu, P.-I.; Fang, P.-C.; Ho, R.-W.; Chao, T.-L.; Cho, W.-H.; Lai, H.-Y.; Hsiao, Y.-T.; Kuo, M.-T. Determination of Tear Lipid Film Thickness Based on a Reflected Placido Disk Tear Film Analyzer. Diagnostics 2020, 10, 353.

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