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Open AccessArticle

Photoacoustic Spectral Sensing Technique for Diagnosis of Biological Tissue Coagulation: In-Vitro Study

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Discipline of Electrical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India
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Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 440-746, Korea
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BC Photonics Technology Co., Richmond, BC V7E 1G9, Canada
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Discipline of Biosciences and Biomedical Engineering, Indian Institute of Technology Indore, Khandwa Road, Simrol, Madhya Pradesh 453552, India
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Authors to whom correspondence should be addressed.
Diagnostics 2020, 10(3), 133; https://doi.org/10.3390/diagnostics10030133
Received: 29 December 2019 / Revised: 17 February 2020 / Accepted: 24 February 2020 / Published: 29 February 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
Thermal coagulation of abnormal tissues has evolved as a therapeutic technique for different diseases including cancer. Tissue heating beyond 55 °C causes coagulation that leads to cell death. Noninvasive diagnosis of thermally coagulated tissues is pragmatic for performing efficient therapy as well as reducing damage of surrounding healthy tissues. We propose a noninvasive, elasticity-based photoacoustic spectral sensing technique for differentiating normal and coagulated tissues. Photoacoustic diagnosis is performed for quantitative differentiation of normal and coagulated excised chicken liver and muscle tissues in vitro by characterizing a dominant frequency of photoacoustic frequency spectrum. Pronounced distinction in the spectral parameter (i.e., dominant frequency) was observed due to change in tissue elastic property. We confirmed nearly two-fold increase in dominant frequencies for the coagulated muscle and liver tissues as compared to the normal ones. A density increase caused by tissue coagulation is clearly reflected in the dominant frequency composition. Experimental results were consistent over five different sample sets, delineating the potential of proposed technique to diagnose biological tissue coagulation and thus monitor thermal coagulation therapy in clinical applications. View Full-Text
Keywords: photoacoustic diagnosis; spectral response; thermal coagulation; dominant frequency photoacoustic diagnosis; spectral response; thermal coagulation; dominant frequency
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Biswas, D.; Chen, G.C.K.; Baac, H.W.; Vasudevan, S. Photoacoustic Spectral Sensing Technique for Diagnosis of Biological Tissue Coagulation: In-Vitro Study. Diagnostics 2020, 10, 133.

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