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Diagnostics
Volume 10
Issue 12
10.3390/diagnostics10120998
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Article

FDG PET/CT Findings of Castleman Disease Assessed by Histologic Subtypes and Compared with Laboratory Findings

by
Eun Ji Han
1,
Joo Hyun O
2,*,
Seung-Eun Jung
3,
Gyeongsin Park
4,
Byung-Ock Choi
5,
Young-Woo Jeon
6,
Gi-June Min
7 and
Seok-Goo Cho
7,†
1
Division of Nuclear Medicine, Department of Radiology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
2
Division of Nuclear Medicine, Department of Radiology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
3
Department of Radiology, Eunpyeong St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
4
Department of Hospital Pathology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
5
Department of Radiation Oncology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
6
Department of Hematology, Yeouido St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
7
Department of Hematology, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea
*
Author to whom correspondence should be addressed.
†
On behalf of Catholic University Lymphoma Group.
Diagnostics 2020, 10(12), 998; https://doi.org/10.3390/diagnostics10120998
Received: 17 October 2020 / Revised: 20 November 2020 / Accepted: 21 November 2020 / Published: 24 November 2020
(This article belongs to the Section Medical Imaging and Theranostics)
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Abstract

Castleman disease (CD) is a relatively rare lymphoproliferative disorder and the pathophysiology of the subtypes are incompletely understood. Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) demonstrates the metabolic activity of inflammatory and tumorous conditions. The FDG uptake intensity and sites of involved lesions on FDG PET/CT were assessed by histologic subtypes, and compared to the patient’s hemoglobin, platelet, albumin, and high-sensitivity C-reactive protein (hs-CRP) levels. In total, 60 PET/CT images of 44 consecutive CD patients were included: 4 (9%) unicentric and 40 (91%) multicentric; 21 (48%) hyaline vascular subtype, 16 (36%) plasma cell, and 7 (16%) mixed or unclassified. The maximum standardized uptake value (SUVmax) and tumor-to-liver (T/L) ratio of involved lymph nodes (LNs) were 5.3 ± 2.4 (range, 1.6–11.5) and 2.8 ± 1.6 (range, 1.1–9.6), respectively, with no significant difference between the histologic subtypes. Higher number of involved LN stations and presence of extra-nodal involvement on FDG PET/CT were associated with thrombocytopenia, hypoalbuminemia, and elevated hs-CRP levels (p values < 0.05). FDG-avidity was not different by histologic subtypes and did not correlate with laboratory findings. However, the extent of nodal and extra-nodal involvement as noted on FDG PET/CT was significantly associated with abnormal laboratory findings in patients with CD. View Full-Text
Keywords: castleman disease; FDG; PET/CT; thrombocytopenia; hypoalbuminemia castleman disease; FDG; PET/CT; thrombocytopenia; hypoalbuminemia
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
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MDPI and ACS Style

Han, E.J.; O, J.H.; Jung, S.-E.; Park, G.; Choi, B.-O.; Jeon, Y.-W.; Min, G.-J.; Cho, S.-G. FDG PET/CT Findings of Castleman Disease Assessed by Histologic Subtypes and Compared with Laboratory Findings. Diagnostics 2020, 10, 998. https://doi.org/10.3390/diagnostics10120998

AMA Style

Han EJ, O JH, Jung S-E, Park G, Choi B-O, Jeon Y-W, Min G-J, Cho S-G. FDG PET/CT Findings of Castleman Disease Assessed by Histologic Subtypes and Compared with Laboratory Findings. Diagnostics. 2020; 10(12):998. https://doi.org/10.3390/diagnostics10120998

Chicago/Turabian Style

Han, Eun J., Joo H. O, Seung-Eun Jung, Gyeongsin Park, Byung-Ock Choi, Young-Woo Jeon, Gi-June Min, and Seok-Goo Cho. 2020. "FDG PET/CT Findings of Castleman Disease Assessed by Histologic Subtypes and Compared with Laboratory Findings" Diagnostics 10, no. 12: 998. https://doi.org/10.3390/diagnostics10120998

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