Next Article in Journal
A Novel and Simple Exercise Test Parameter to Assess Responsiveness to Cardiac Resynchronization Therapy
Next Article in Special Issue
Evaluation of Pre-Therapeutic Assessment in Endometrial Cancer Staging
Previous Article in Journal
Prevalence and Impact of Reported Drug Allergies among Rheumatology Patients
Previous Article in Special Issue
Neutrophil/Lymphocyte Ratio as Predictor of Anastomotic Leak after Gastric Cancer Surgery
Article

Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study

1
Department of Diagnostic Radiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138510, Japan
2
Department of Hepatobiliary and Pancreatic Surgery, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138510, Japan
3
Department of Molecular Oncology, Graduate School of Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 1138510, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(11), 919; https://doi.org/10.3390/diagnostics10110919
Received: 8 October 2020 / Revised: 5 November 2020 / Accepted: 6 November 2020 / Published: 9 November 2020
(This article belongs to the Special Issue Abdominal Surgical Diseases: Diagnosis, Treatment and Management)
Paired box 6 (PAX6) is a transcription factor that plays a critical role in tumor suppression, implying that the downregulation of PAX6 promotes tumor growth and invasiveness. This study aimed to examine dynamic computed tomography (CT) features for predicting pancreatic neuroendocrine neoplasms (Pan-NENs) with low PAX6 expression. We retrospectively evaluated 51 patients with Pan-NENs without synchronous liver metastasis to assess the pathological expression of PAX6. Two radiologists analyzed preoperative dynamic CT images to determine morphological features and enhancement patterns. We compared the CT findings between low and high PAX6 expression groups. Pathological analysis identified 11 and 40 patients with low and high PAX6 expression, respectively. Iso- or hypoenhancement types in the arterial and portal phases were significantly associated with low PAX6 expression (p = 0.009; p = 0.001, respectively). Low PAX6 Pan-NENs showed a lower portal enhancement ratio than high PAX6 Pan-NENs (p = 0.044). The combination based on enhancement types (iso- or hypoenhancement during arterial and portal phases) and portal enhancement ratio (≤1.22) had 54.5% sensitivity, 92.5% specificity, and 84.3% accuracy in identifying low PAX6 Pan-NENs. Dynamic CT features, including iso- or hypoenhancement types in the arterial and portal phases and lower portal enhancement ratio may help predict Pan-NENs with low PAX6 expression. View Full-Text
Keywords: pancreas; neuroendocrine Tumors; PAX6 pancreas; neuroendocrine Tumors; PAX6
Show Figures

Figure 1

MDPI and ACS Style

Kimura, K.; Tsuchiya, J.; Kitazume, Y.; Kishino, M.; Akahoshi, K.; Kudo, A.; Tanaka, S.; Tanabe, M.; Tateishi, U. Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study. Diagnostics 2020, 10, 919. https://doi.org/10.3390/diagnostics10110919

AMA Style

Kimura K, Tsuchiya J, Kitazume Y, Kishino M, Akahoshi K, Kudo A, Tanaka S, Tanabe M, Tateishi U. Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study. Diagnostics. 2020; 10(11):919. https://doi.org/10.3390/diagnostics10110919

Chicago/Turabian Style

Kimura, Koichiro, Junichi Tsuchiya, Yoshio Kitazume, Mitsuhiro Kishino, Keiichi Akahoshi, Atsushi Kudo, Shinji Tanaka, Minoru Tanabe, and Ukihide Tateishi. 2020. "Dynamic Enhancement Pattern on CT for Predicting Pancreatic Neuroendocrine Neoplasms with Low PAX6 Expression: A Retrospective Observational Study" Diagnostics 10, no. 11: 919. https://doi.org/10.3390/diagnostics10110919

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop