Support Values for Genome Phylogenies
AbstractWe have recently developed a distance metric for efficiently estimating the number of substitutions per site between unaligned genome sequences. These substitution rates are called “anchor distances” and can be used for phylogeny reconstruction. Most phylogenies come with bootstrap support values, which are computed by resampling with replacement columns of homologous residues from the original alignment. Unfortunately, this method cannot be applied to anchor distances, as they are based on approximate pairwise local alignments rather than the full multiple sequence alignment necessary for the classical bootstrap. We explore two alternatives: pairwise bootstrap and quartet analysis, which we compare to classical bootstrap. With simulated sequences and 53 human primate mitochondrial genomes, pairwise bootstrap gives better results than quartet analysis. However, when applied to 29 E. coli genomes, quartet analysis comes closer to the classical bootstrap. View Full-Text
Share & Cite This Article
Klötzl, F.; Haubold, B. Support Values for Genome Phylogenies. Life 2016, 6, 11.
Klötzl F, Haubold B. Support Values for Genome Phylogenies. Life. 2016; 6(1):11.Chicago/Turabian Style
Klötzl, Fabian; Haubold, Bernhard. 2016. "Support Values for Genome Phylogenies." Life 6, no. 1: 11.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.