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Support Values for Genome Phylogenies

Department of Evolutionary Genetics, Max-Planck-Institute for Evolutionary Biology, August-Thienemann-Straße 2, 24306 Plön, Germany
Author to whom correspondence should be addressed.
Academic Editor: Alexander Bolshoy
Received: 7 December 2015 / Revised: 3 February 2016 / Accepted: 23 February 2016 / Published: 7 March 2016
(This article belongs to the Special Issue Structure and Evolution of Genome)
PDF [599 KB, uploaded 7 March 2016]


We have recently developed a distance metric for efficiently estimating the number of substitutions per site between unaligned genome sequences. These substitution rates are called “anchor distances” and can be used for phylogeny reconstruction. Most phylogenies come with bootstrap support values, which are computed by resampling with replacement columns of homologous residues from the original alignment. Unfortunately, this method cannot be applied to anchor distances, as they are based on approximate pairwise local alignments rather than the full multiple sequence alignment necessary for the classical bootstrap. We explore two alternatives: pairwise bootstrap and quartet analysis, which we compare to classical bootstrap. With simulated sequences and 53 human primate mitochondrial genomes, pairwise bootstrap gives better results than quartet analysis. However, when applied to 29 E. coli genomes, quartet analysis comes closer to the classical bootstrap. View Full-Text
Keywords: bootstrap; quartet analysis; support value; phylogeny; distance matrix bootstrap; quartet analysis; support value; phylogeny; distance matrix

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Klötzl, F.; Haubold, B. Support Values for Genome Phylogenies. Life 2016, 6, 11.

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