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Synergism and Mutualism in Non-Enzymatic RNA Polymerization

Department of Polymer Science, The University of Akron, Akron, OH 44325-3909, USA
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Life 2014, 4(4), 598-620; https://doi.org/10.3390/life4040598
Received: 18 September 2014 / Revised: 15 October 2014 / Accepted: 17 October 2014 / Published: 3 November 2014
(This article belongs to the Special Issue Protocells - Designs for Life)
The link between non-enzymatic RNA polymerization and RNA self-replication is a key step towards the “RNA world” and still far from being solved, despite extensive research. Clay minerals, lipids and, more recently, peptides were found to catalyze the non-enzymatic synthesis of RNA oligomers. Herein, a review of the main models for the formation of the first RNA polymers is presented in such a way as to emphasize the cooperation between life’s building blocks in their emergence and evolution. A logical outcome of the previous results is a combination of these models, in which RNA polymerization might have been catalyzed cooperatively by clays, lipids and peptides in one multi-component prebiotic soup. The resulting RNAs and oligopeptides might have mutualistically evolved towards functional RNAs and catalytic peptides, preceding the first RNA replication, thus supporting an RNA-peptide world. The investigation of such a system is a formidable challenge, given its complexity deriving from a tremendously large number of reactants and innumerable products. A rudimentary experimental design is outlined, which could be used in an initial attempt to study a quaternary component system. View Full-Text
Keywords: activated nucleotides; peptides; single-chain amphiphile; mineral surfaces; protocell; organocatalysis; RNA polymerization; RNA-peptide world activated nucleotides; peptides; single-chain amphiphile; mineral surfaces; protocell; organocatalysis; RNA polymerization; RNA-peptide world
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Kaddour, H.; Sahai, N. Synergism and Mutualism in Non-Enzymatic RNA Polymerization. Life 2014, 4, 598-620.

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