Leptomeningitis as Rare Secondary Dissemination in MEITL (Monomorphic Intestinal Epitheliotropic T-Cell Lymphoma)
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
ALS | amyotrophic lateral sclerosis |
CD | lymphocyte-specific surface makers |
CT | computed tomography |
DCRT | definite chemoradiotherapy |
EATL | enteropathy-associated T-cell lymphoma |
ESR | erythrocytes sedimentation rate |
HSCT | hematopoietic stem cell transplantation |
MRI | magnetic resonance imaging |
MEITL | monomorphic epitheliotropic intestinal T-cell lymphoma |
PET-CT | positron emission tomography-computed tomography |
WHO | World Health Organization |
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RELEVANT CSF ANALYSIS FINDINGS | COMMENTS ON THE INTERPRETATION OF RESULTS |
---|---|
Albumin levels—99 mg/dL (reference interval 10–30 mg/dL) | Indicative for blood–brain barrier impairment; significantly increased protein may suggest CNS tuberculosis, also fungal, or neoplastic meningitis |
Chlorides 115 mmol/L (reference interval 118–132 mmol/L) | Normal level |
Glycorrhachia—50 mg/dL (reference interval 50–80 mg/dL) | Normal level |
Pandy +++ reaction | Strongly positive—indicates significant elevation in globulins (protein inflammation) |
Cell Count: 175 elements/mmc, with 80% monomorphic lymphocytes (normal interval 175 elements/mm3) | Pleocytosis with lymphocytic predominance may suggests chronic inflammation, such as tuberculosis, fungal, viral, or neoplastic meningitis. |
Negative bacterial cultures | No bacterial growth—argues against acute bacterial meningitis |
Opalescent appearance, xanthochrome liquid | Suggests prior bleeding (xanthochromia) and protein elevation |
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Lungu, M.; Oprea, V.D.; Niculeț, E.; Apostol, L.L.; Păduraru, M.I.; Ionescu, A.M.; Zaharia, A.L. Leptomeningitis as Rare Secondary Dissemination in MEITL (Monomorphic Intestinal Epitheliotropic T-Cell Lymphoma). Life 2025, 15, 1243. https://doi.org/10.3390/life15081243
Lungu M, Oprea VD, Niculeț E, Apostol LL, Păduraru MI, Ionescu AM, Zaharia AL. Leptomeningitis as Rare Secondary Dissemination in MEITL (Monomorphic Intestinal Epitheliotropic T-Cell Lymphoma). Life. 2025; 15(8):1243. https://doi.org/10.3390/life15081243
Chicago/Turabian StyleLungu, Mihaiela, Violeta Diana Oprea, Elena Niculeț, Luminița Lăcrămioara Apostol, Marius Ionuț Păduraru, Ana Maria Ionescu, and Andrei Lucian Zaharia. 2025. "Leptomeningitis as Rare Secondary Dissemination in MEITL (Monomorphic Intestinal Epitheliotropic T-Cell Lymphoma)" Life 15, no. 8: 1243. https://doi.org/10.3390/life15081243
APA StyleLungu, M., Oprea, V. D., Niculeț, E., Apostol, L. L., Păduraru, M. I., Ionescu, A. M., & Zaharia, A. L. (2025). Leptomeningitis as Rare Secondary Dissemination in MEITL (Monomorphic Intestinal Epitheliotropic T-Cell Lymphoma). Life, 15(8), 1243. https://doi.org/10.3390/life15081243