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Reply

Reply to Scarlata, G.G.M.; Abenavoli, L. Comment on “Rotaru et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288”

1
Department of Gastroenterology, Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania
2
Institute of Gastroenterology and Hepatology, “St. Spiridon” University Hospital, 700111 Iasi, Romania
*
Authors to whom correspondence should be addressed.
Life 2025, 15(8), 1211; https://doi.org/10.3390/life15081211
Submission received: 2 July 2025 / Revised: 21 July 2025 / Accepted: 25 July 2025 / Published: 30 July 2025
(This article belongs to the Section Medical Research)
We are grateful to Dr. Scarlata and Prof. Abenavoli for their insightful and collegial remarks on our recent publication [1,2]. Their engagement highlights the importance of continued academic dialogue around the emerging clinical relevance of metabolic dysfunction-associated steatotic liver disease (MASLD) in patients with inflammatory bowel disease (IBD). We fully share their view on the relevance of reclassifying non-alcoholic fatty liver disease under the MASLD terminology, and we appreciate their emphasis on the gut–liver axis as a central pathophysiological mechanism linking these two conditions [3].
We fully endorse their view that the recent terminological transition from NAFLD to MASLD represents more than a nomenclatural change—it reflects a deeper understanding of the cardiometabolic underpinnings of steatotic liver disease, including in patients traditionally considered metabolically healthy by anthropometric measures. In this regard, their pilot study significantly advances the field by demonstrating an 18% prevalence of MASLD among Italian IBD patients—substantially higher than NAFLD (6%)—and by correlating MASLD with increased disease activity and higher rates of surgical intervention. These findings are congruent with our own clinical observations and mechanistic hypotheses [4]. We also wish to highlight the results of a recent large cohort study by Zhang et al. which confirmed a significantly elevated all-cause mortality risk in IBD patients with MASLD, particularly in the lean MASLD subgroup (HR = 3.14). This finding further emphasizes the urgent need for early hepatic screening in IBD populations regardless of BMI or traditional metabolic risk factors [5].
Also, over the past years, our group has devoted substantial energy and academic focus to elucidating the burden of steatotic liver disease in patients with IBD. In our prospective study published in Journal of Clinical Medicine [6], we were the first to systematically screen a Romanian IBD cohort using vibration-controlled transient elastography with controlled attenuation parameter, documenting a prevalence of NAFLD of 46.3%—a figure significantly higher than that reported in many previous European studies. Beyond merely reporting prevalence, we demonstrated that liver steatosis in IBD is not confined to patients with obesity or overt metabolic syndrome. In our cohort, nearly half of the patients with steatosis had a normal BMI, underscoring the relevance of lean MASLD, a phenotype now gaining increasing recognition. Moreover, we identified independent associations between hepatic steatosis and age, BMI, CRP, disease duration, fasting glucose, triglycerides, and type 2 diabetes, reflecting both inflammatory and metabolic drivers. A quarter of our patients also exhibited significant fibrosis (≥F2), reinforcing the silent but progressive nature of liver injury in IBD.
Taken together, the converging evidence from our group and colleagues such as Abenavoli and Scarlata strongly argues for an updated clinical framework that integrates hepatologic screening into routine IBD care. This approach should transcend BMI thresholds and instead focus on metabolic and inflammatory profiles. It is increasingly clear that lean individuals are not exempt from MASLD or its complications. We appreciate the authors’ call for multidisciplinary management and agree that future prospective studies should explore how emerging IBD therapies—including biologics—may modulate hepatic outcomes, particularly in lean MASLD phenotypes.

Author Contributions

Conceptualization, C.S. (Carol Stanciu), A.T., A.R. and R.S.; methodology, S.Z., R.S., A.R., R.N. and E.S.; software, S.Z. and C.S. (Catalin Sfarti); formal analysis, A.R., R.S., L.H. and T.C.; investigation, A.T., A.-M.S., R.S., S.C. and C.M.; data curation, I.G., R.S. and E.S.; writing—original draft preparation, A.T., R.S. and A.R.; writing—review and editing, A.T., S.C. and R.S.; visualization, C.S. (Catalin Sfarti) and H.M.; supervision, A.T. and C.S. (Carol Stanciu). All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of St. Spiridon Hospital Iasi (protocol code 125, date of approval 21 December 2023).

Data Availability Statement

The data presented in this study are available upon request from the corresponding author. The data are not publicly available because they are the property of the Institute of Gastroenterology and Hepatology, Iasi, Romania.

Acknowledgments

We gratefully acknowledge the colleagues and patients who enabled us to write this manuscript.

Conflicts of Interest

The authors declare no conflicts of interest.

Abbreviations

The following abbreviations are used in this manuscript:
IBDInflammatory bowel disease
NAFLDNonalcoholic Fatty Liver Disease
MASLDMetabolic Dysfunction-associated Steatotic Liver Disease
BMIBody Mass Index
CRPC-Reactive Protein

References

  1. Scarlata, G.G.M.; Abenavoli, L. Comment on Rotaru et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288. Life 2025, 15, 1210. [Google Scholar] [CrossRef]
  2. Rotaru, A.; Stafie, R.; Stratina, E.; Zenovia, S.; Nastasa, R.; Minea, H.; Huiban, L.; Cuciureanu, T.; Muzica, C.; Chiriac, S.; et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288. [Google Scholar] [CrossRef] [PubMed]
  3. Rinella, M.E.; Lazarus, J.V.; Ratziu, V.; Francque, S.M.; Sanyal, A.J.; Kanwal, F.; Romero, D.; Abdelmalek, M.F.; Anstee, Q.M.; Arab, J.P.; et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology 2023, 78, 1966–1986. [Google Scholar] [CrossRef] [PubMed]
  4. Abenavoli, L.; Spagnuolo, R.; Scarlata, G.G.M.; Gambardella, M.L.; Boccuto, L.; Méndez-Sánchez, N.; Luzza, F. Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Inflammatory Bowel Diseases: A Pilot Study. Life 2024, 14, 1226. [Google Scholar] [CrossRef] [PubMed]
  5. Zhang, Q.; Wang, Y.; Liu, S.; Zhu, S.; Li, P.; Wu, S. Mortality risk associated with MASLD, MASLD type and different cardiometabolic risk factors in IBD patients: A long-term prospective cohort study. Dig. Liver Dis. 2025, 57, 744–752. [Google Scholar] [CrossRef] [PubMed]
  6. Trifan, A.; Stafie, R.; Rotaru, A.; Stratina, E.; Zenovia, S.; Nastasa, R.; Huiban, L.; Cuciureanu, T.; Muzica, C.; Chiriac, S.; et al. Screening for Liver Steatosis and Fibrosis in Patients with Inflammatory Bowel Disease Using Vibration Controlled Transient Elastography with Controlled Attenuation Parameter. J. Clin. Med. 2022, 11, 5959. [Google Scholar] [CrossRef] [PubMed]
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MDPI and ACS Style

Rotaru, A.; Stafie, R.; Stratina, E.; Zenovia, S.; Nastasa, R.; Minea, H.; Huiban, L.; Cuciureanu, T.; Muzica, C.; Chiriac, S.; et al. Reply to Scarlata, G.G.M.; Abenavoli, L. Comment on “Rotaru et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288”. Life 2025, 15, 1211. https://doi.org/10.3390/life15081211

AMA Style

Rotaru A, Stafie R, Stratina E, Zenovia S, Nastasa R, Minea H, Huiban L, Cuciureanu T, Muzica C, Chiriac S, et al. Reply to Scarlata, G.G.M.; Abenavoli, L. Comment on “Rotaru et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288”. Life. 2025; 15(8):1211. https://doi.org/10.3390/life15081211

Chicago/Turabian Style

Rotaru, Adrian, Remus Stafie, Ermina Stratina, Sebastian Zenovia, Robert Nastasa, Horia Minea, Laura Huiban, Tudor Cuciureanu, Cristina Muzica, Stefan Chiriac, and et al. 2025. "Reply to Scarlata, G.G.M.; Abenavoli, L. Comment on “Rotaru et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288”" Life 15, no. 8: 1211. https://doi.org/10.3390/life15081211

APA Style

Rotaru, A., Stafie, R., Stratina, E., Zenovia, S., Nastasa, R., Minea, H., Huiban, L., Cuciureanu, T., Muzica, C., Chiriac, S., Girleanu, I., Singeap, A.-M., Sfarti, C., Stanciu, C., & Trifan, A. (2025). Reply to Scarlata, G.G.M.; Abenavoli, L. Comment on “Rotaru et al. Lean MASLD and IBD: Exploring the Intersection of Metabolic Dysfunction and the Gut–Liver Axis. Life 2025, 15, 288”. Life, 15(8), 1211. https://doi.org/10.3390/life15081211

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