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Systematic Review

Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis

by
Mathias Orellana-Donoso
1,2,
Daniel Milos-Brandenberg
3,
Andoni Benavente-Urtubia
2,
Javier Guerra-Loyola
2,
Alejandro Bruna-Mejias
2,
Pablo Nova-Baeza
2,
Álvaro Becerra-Farfán
4,
Walter Sepulveda-Loyola
5,
Ricardo Miguel Luque-Bernal
6 and
Juan José Valenzuela-Fuenzalida
2,7,*
1
Escuela de Medicina, Universidad Finis Terrae, Santiago 7500000, Chile
2
Departamento de Morfología, Facultad de Medicina, Universidad Andrés Bello, Santiago 8370146, Chile
3
Escuela de Medicina, Facultad Ciencias de la Salud, Universidad del Alba, Santiago 8320000, Chile
4
Departamento de Ciencias Química y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O’Higgins, Santiago 8370993, Chile
5
Faculty of Health and Social Sciences, Universidad de las Américas, Santiago 8370040, Chile
6
Unidad de Anatomía, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá 111221, Colombia
7
Department of Morphology and Function, Faculty of Health and Social Sciences, Universidad de Las Américas, Santiago 8370040, Chile
*
Author to whom correspondence should be addressed.
Life 2023, 13(8), 1710; https://doi.org/10.3390/life13081710
Submission received: 11 July 2023 / Revised: 27 July 2023 / Accepted: 3 August 2023 / Published: 9 August 2023
(This article belongs to the Special Issue Pancreatectomy and Pancreatic Surgery)
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Abstract

Objective: This systematic review analyzes the anatomical variants in the pancreas and its ductal system to report on their association with pancreatic pathologies. Methods: We conducted a search of the MEDLINE, Scopus, Web of Science, Google Scholar, CINAHL, and LILACS databases from their inception to July 2023. The methodological quality was assessed with the Anatomical Quality Assessment (AQUA) tool. Finally, the pooled prevalence was estimated using a random effects model. Results: 55 studies were found that met the eligibility criteria. The overall prevalence of pancreas divisum (PD) was 18% (95% CI = 15–21%). The prevalence of PD associated with pancreatitis was 30% (95% CI = 1–61%). Conclusions: An anatomical variant of the pancreas such as PD may be the cause of bile duct obstruction, resulting in various clinical complications, such as pancreatitis. Hence, knowing this variant is extremely important for surgeons, especially for those who treat the gastroduodenal region.
Keywords: variations anatomical pancreas; ductal pancreas; anatomical variations; pancreatitis; clinical anatomy variations anatomical pancreas; ductal pancreas; anatomical variations; pancreatitis; clinical anatomy

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MDPI and ACS Style

Orellana-Donoso, M.; Milos-Brandenberg, D.; Benavente-Urtubia, A.; Guerra-Loyola, J.; Bruna-Mejias, A.; Nova-Baeza, P.; Becerra-Farfán, Á.; Sepulveda-Loyola, W.; Luque-Bernal, R.M.; Valenzuela-Fuenzalida, J.J. Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis. Life 2023, 13, 1710. https://doi.org/10.3390/life13081710

AMA Style

Orellana-Donoso M, Milos-Brandenberg D, Benavente-Urtubia A, Guerra-Loyola J, Bruna-Mejias A, Nova-Baeza P, Becerra-Farfán Á, Sepulveda-Loyola W, Luque-Bernal RM, Valenzuela-Fuenzalida JJ. Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis. Life. 2023; 13(8):1710. https://doi.org/10.3390/life13081710

Chicago/Turabian Style

Orellana-Donoso, Mathias, Daniel Milos-Brandenberg, Andoni Benavente-Urtubia, Javier Guerra-Loyola, Alejandro Bruna-Mejias, Pablo Nova-Baeza, Álvaro Becerra-Farfán, Walter Sepulveda-Loyola, Ricardo Miguel Luque-Bernal, and Juan José Valenzuela-Fuenzalida. 2023. "Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis" Life 13, no. 8: 1710. https://doi.org/10.3390/life13081710

APA Style

Orellana-Donoso, M., Milos-Brandenberg, D., Benavente-Urtubia, A., Guerra-Loyola, J., Bruna-Mejias, A., Nova-Baeza, P., Becerra-Farfán, Á., Sepulveda-Loyola, W., Luque-Bernal, R. M., & Valenzuela-Fuenzalida, J. J. (2023). Incidence and Clinical Implications of Anatomical Variations in the Pancreas and Its Ductal System: A Systematic Review and Meta-Analysis. Life, 13(8), 1710. https://doi.org/10.3390/life13081710

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