How to Provide Breast Milk for the Preterm Infant and Avoid Symptomatic Cytomegalovirus Infection with Possible Long-Term Sequelae
Abstract
:1. Introduction
2. The Rationale for Feeding Human Milk to the Preterm Infant
2.1. Human Breast Milk and the Preterm Infant
2.2. Donor Human Milk and Milk Banking
3. Postnatal Cytomegalovirus Infection
3.1. Short-Term Sequelae of Postnatal CMV Infection
3.2. Potential Adverse Long-Term Neurodevelopmental of Postnatal CMV Infection
3.3. Are All Preterm Infants Prone to the Risk of Symptomatic CMV Disease?
4. Preventing Postnatal CMV Infection
5. Discussion
6. Conclusions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
- Meier, J.; Lienicke, U.; Tschirch, E.; Krüger, D.H.; Wauer, R.R.; Prösch, S. Human cytomegalovirus reactivation during lactation and mother-to-child transmission in preterm infants. J. Clin. Microbiol. 2005, 43, 1318–1324. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Yasuda, A.; Kimura, H.; Hayakawa, M.; Ohshiro, M.; Kato, Y.; Matsuura, O.; Suzuki, C.; Morishima, T. Evaluation of cytomegalovirus infections transmitted via breast milk in preterm infants with a real-time polymerase chain reaction assay. Pediatrics 2003, 111, 1333–1336. [Google Scholar] [CrossRef] [PubMed]
- Jim, W.T.; Shu, C.H.; Chiu, N.C.; Kao, H.A.; Hung, H.Y.; Chang, J.H.; Peng, C.C.; Hsieh, W.S.; Liu, K.C.; Huang, F.Y. Transmission of cytomegalovirus from mothers to preterm infants by breast milk. Pediatr. Infect. Dis. J. 2004, 23, 848–851. [Google Scholar] [CrossRef] [PubMed]
- Kurath, S.; Halwachs-Baumann, G.; Müller, W.; Resch, B. Transmission of cytomegalovirus via breast milk to the prematurely born infant: A systematic review. Clin. Microbiol. Infect. 2010, 16, 1172–1178. [Google Scholar] [CrossRef] [PubMed]
- Fouda, G.G.; Martinez, D.R.; Swamy, G.K.; Permar, S.R. The impact of IgG transplacental transfer on early life immunity. Immunohorizons 2018, 2, 14–25. [Google Scholar] [CrossRef]
- Pham, Q.; Patel, P.; Baban, B.; Yu, J.; Bhatia, J. Factors Affecting the Composition of Expressed Fresh Human Milk. Breastfeed. Med. 2020, 15, 551–558. [Google Scholar] [CrossRef]
- Moro, G.E.; Billeaud, C.; Rachel, B.; Calvo, J.; Cavallarin, L.; Christen, L.; Vieco, D.-E.; Gaya, A.; Lembo, D.; Wesolowska, A.; et al. Processing of Donor Human Milk: Update and Recommendations from the European Milk Bank Association (EMBA). Front. Pediatr Front Pediatr. 2019, 7, 49. [Google Scholar] [CrossRef] [Green Version]
- Boquien, C.-Y. Human Milk: An Ideal Food for Nutrition of Preterm Newborn. Front. Pediatr. 2018, 6, 295. [Google Scholar] [CrossRef] [Green Version]
- Buckley, K.M.; Charles, G.E. Benefits and challenges of transitioning preterm infants to at-breast feedings. Int. Breastfeed. J. 2006, 1, 13. [Google Scholar] [CrossRef] [Green Version]
- Fleischer, D.M. The Impact of Breastfeeding on the Development of Allergic Disease. UptoDate 2020. Available online: https://www.uptodate.com/contents/the-impact-of-breastfeeding-on-the-development-of-allergic-disease (accessed on 4 March 2022).
- Kawasaki, T.; Kawai, T. Toll-like receptor signaling pathways. Front Immunol. 2014, 5, 461. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Abrams, S.A.; Hurst, N.M. Breastfeeding the Preterm Infant. UptoDate 2021. Available online: https://www.uptodate.com/contents/breastfeeding-the-preterm-infant (accessed on 4 March 2022).
- Morgan, J.; Bombell, S.; McGuire, W. Early trophic feeding versus enteral fasting for very preterm or very low birth weight infants. Cochrane Database Syst Rev. 2013. [Google Scholar] [CrossRef] [PubMed]
- Berseth, C.L. Effect of early feeding on maturation of the preterm infant’s small intestine. J. Pediatr. 1992, 120, 947. [Google Scholar] [CrossRef]
- Lucas, A.; Bloom, S.R.; Aynsley-Green, A. Gut hormones and ‘minimal enteral feeding’. Acta Paediatr. Scand. 1986, 75, 719. [Google Scholar] [CrossRef]
- Meetze, W.H.; Valentine, C.; McGuigan, J.E.; Conlon, M.; Sacks, N.; Neu, J. Gastrointestinal priming prior to full enteral nutrition in very low birth weight infants. J. Pediatr. Gastroenterol. Nutr. 1992, 15, 163. [Google Scholar] [CrossRef]
- Dunn, L.; Hulman, S.; Weiner, J.; Kliegman, R. Beneficial effects of early hypocaloric enteral feeding on neonatal gastrointestinal function: Preliminary report of a randomized trial. J. Pediatr. 1988, 112, 622. [Google Scholar] [CrossRef]
- Slagle, T.A.; Gross, S.J. Effect of early low-volume enteral substrate on subsequent feeding tolerance in very low birth weight infants. J. Pediatr. 1988, 113, 526. [Google Scholar] [CrossRef]
- Shulman, R.J.; Schanler, R.J.; Lau, C.; Heitkemper, M.; Ou, C.N.; Smith, E.B. Early feeding, feeding tolerance, and lactase activity in preterm infants. J. Pediatr. 1998, 133, 645. [Google Scholar] [CrossRef]
- Shulman, R.J.; Schanler, R.J.; Lau, C.; Heitkemper, M.; Ou, C.N.; Smith, E.O. Early feeding, antenatal glucocorticoids, and human milk decrease intestinal permeability in preterm infants. Pediatr. Res. 1998, 44, 519. [Google Scholar] [CrossRef]
- Terrin, G.; Passariello, A.; Canani, R.B.; Manguso, F.; Paludetto, R.; Cascioli, C. Minimal enteral feeding reduces the risk of sepsis in feed-intolerant very low birth weight newborns. Acta Paediatr. 2009, 98, 31. [Google Scholar] [CrossRef]
- Haiden, N.; Ziegler, E.E. Human Milk Banking. Ann. Nutr. Metab. 2016, 69 (Suppl. 2), 8–15. [Google Scholar] [CrossRef] [PubMed]
- Picaud, J.C. Review highlights importance of donor human milk being available for very low birth weight infants. Acta Paediatr. 2022. [Google Scholar] [CrossRef] [PubMed]
- Arslanoglu, S.; Corpeleijn, W.; Moro, G.; Braegger, C.; Campoy, C.; Colomb, V.; Decsi, T.; Domellöf, M.; Fewtrell, M.; Hojsak, I.; et al. Donor human milk for preterm infants: Current evidence and research directions. J. Pediatr. Gastroenterol. Nutr. 2013, 57, 535–542. [Google Scholar] [CrossRef]
- Quigley, M.A.; Henderson, G.; Anthony, N.Y.; McGuire, W. Formula milk versus donor breast milk for feeding preterm or low birth weight infants. Cochrane Database Syst Rev. 2007, CD002971. [Google Scholar] [CrossRef]
- Boyd, C.A.; Quigley, M.A.; Brocklehurst, P. Donor breast milk versus infant formula for preterm infants: Systematic review and meta-analysis. Arch. Dis. Child. Fetal Neonatal Ed. 2007, 92, F169–F175. [Google Scholar] [CrossRef] [Green Version]
- McGuire, W.; Anthony, M.Y. Donor human milk versus formula for preventing necrotising enterocolitis in preterm infants: Systematic review. Arch. Dis. Child. Fetal Neonatal Ed. 2003, 88, F11–F14. [Google Scholar] [CrossRef]
- Centers for Disease Control and Prevention. Cytomegalovirus (CMV) and Congenital CMV Infection. Available online: https://www.cdc.gov/cmv/clinical/overview.html (accessed on 4 March 2022).
- Osterholm, E.A.; Schleiss, M.R. Impact of breast milk-acquired cytomegalovirus infection in premature infants: Pathogenesis, prevention, and clinical consequences? Rev. Med. Virol. 2020, 30, 1–11. [Google Scholar] [CrossRef] [PubMed]
- Patel, R.M.; Shenvi, N.; Knezevic, A.; Hinkes, M.; Bugg, G.W.; Stowell, S.R.; Roback, J.D.; Easley, K.A.; Josephson, C. Observational study of cytomegalovirus from breast milk and necrotising enterocolitis. Arch. Dis. Child. Fetal Neonatal Ed. 2019, 105, 259–265. [Google Scholar] [CrossRef] [Green Version]
- Hamele, M.; Flanagan, R.; Loomins, A.; Stevens, T.; Faircock, M.P. Severe morbidity and mortality with breast milk associated cytomegalovirus infection. Pediatr. Infect. Dis. J. 2010, 29, 84–86. [Google Scholar] [CrossRef]
- Volder, C.; Work, B.J.; Hoegh, S.V.; Eckhardt, M.C.; Zachariassen, G. Transmission of cytomegalovirus in fresh and freeze-thawed mother’s own milk to very preterm infants: A cohort study. J. Perinatol. 2021, 41, 1873–1878. [Google Scholar] [CrossRef]
- Vollmer, B.; Seibold-Weiger, K.; Schmitz-Salue, C.; Hamprecht, K.; Goelz, R.; Krageloh-Mann, I.; Speer, C.P. Postnatally acquired cytomegalovirus infection via breast milk: Effects on hearing and development in preterm infants. Pediatr. Infect. Dis. J. 2004, 23, 322–327. [Google Scholar] [CrossRef] [PubMed]
- Bevot, A.; Hamprecht, K.; Krägeloh-Mann, I.; Brosch, S.; Goelz, R.; Vollmer, B. Long-term outcome in preterm children with human cytomegalovirus infection transmitted via breast milk. Acta Paediatr. 2012, 101, e167–e172. [Google Scholar] [CrossRef] [PubMed]
- Goelz, R.; Meisner, C.; Bevot, A.; Hamprecht, K.; Kraegeloh-Mann, I.; Poets, C.F. Long-term cognitive and neurological outcome of preterm infants with postnatally acquired CMV infection through breast milk. Arch. Dis. Child. Fetal Neonatal Ed. 2013, 98, F430–F433. [Google Scholar] [CrossRef] [PubMed]
- Brecht, K.F.; Goelz, R.; Bevot, A.; Krägeloh-Mann, I.; Wilke, M.; Lidzba, K. Postnatal human cytomegalovirus infection in preterm infants has long-term neuropsychological sequelae. J. Pediatr. 2015, 166, 834–839. [Google Scholar] [CrossRef] [PubMed]
- Dorn, M.; Lidzba, K.; Bevot, A.; Goelz, R.; Till-Karsten, H.; Marko, W. Long-term neurobiological consequences of early postnatal hCMV-infection in former preterms. Human Brain Mapp. 2014, 35, 2594–2606. [Google Scholar] [CrossRef]
- Weimer, K.E.D.; Kelly, M.S.; Permar, S.R.; Clark, R.H.; Greenberg, R.G. Association of adverse hearing, growth, and discharge age outcomes with postnatal cytomegalovirus infection in infants with very low birth weight. JAMA Pediatr. 2020, 174, 133. [Google Scholar] [CrossRef]
- Jobe, A.H. CMV transmission in human milk. J. Pediatr. 2009, 154, A1. [Google Scholar] [CrossRef]
- Kurath, S.; Resch, B. Cytomegalovirus and transmission via breast milk: How to support breast milk to premature infants and prevent severe infection? Pediatr. Infect. Dis. J. 2010, 29, 680–681. [Google Scholar] [CrossRef]
- Miron, D.; Brosilow, S.; Felszer, K.; Reich, D.; Halle, D.; Wachtel, D.; Eidelman, A.I.; Schlesinger, Y. Incidence and clinical manifestations of breast milk-aquired cytomegalovirus infection in low birth weight infants. J. Perinatol. 2005, 25, 299–303. [Google Scholar] [CrossRef]
- Doctor, S.; Friedman, S.; Dunn, M.S.; Asztalos, E.V.; Wylie, L.; Mazzulli, T.; Vearncombe, M.; O’brien, K. Cytomegalovirus transmission to extremely low-birthweight infants through breast milk. Acta Paediatr. 2005, 94, 53–58. [Google Scholar] [CrossRef]
- Vochem, M.; Hamprecht, K.; Jahn, G.; Speer, C.P. Transmission of cytomegalovirus to preterm infants through breast milk. Pediatr Infect. Dis. J. 1998, 17, 53–58. [Google Scholar] [CrossRef] [PubMed]
- Hamprecht, K.; Maschmann, J.; Vochem, M.; Dietz, K.; Speer, C.P.; Jahn, G. Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding. Lancet 2001, 357, 513–518. [Google Scholar] [CrossRef]
- Rieger-Fackeldey, E.; Genzel-Boroviczény, O.; Schulze, A. Schwere systemische Zytomegalie-Virusinfektion Frühgeborener über die Muttermilch. Mon. Kinderheilkd 2001, 149, 1059–1062. [Google Scholar] [CrossRef]
- Hamprecht, K.; Maschmann, J.; Müller, D.; Dietz, K.; Besenthal, I.; Goelz, R.; Middeldorp, J.M.; Speer, C.P.; Jahn, G. Cytomegalovirus (CMV) inactivation in breast milk: Reassessment of pasteurization and freeze-thawing. Pediatr. Res. 2004, 56, 529–535. [Google Scholar] [CrossRef] [Green Version]
- Maschmann, J.; Hamprecht, K.; Weissrich, B.; Dietz, K.; Jahn, G.; Speer, C.P. Freeze-thawing of breast milk does not prevent cytomegalovirus transmission to preterm infants. Arch. Dis. Child. 2006, 91, 288–290. [Google Scholar] [CrossRef] [Green Version]
- Peila, C.; Moro, G.E.; Bertino, E.; Cavallarin, L.; Giribaldi, M.; Giuliani, F.; Cresi, F.; Coscia, A. The Effect of Holder Pasteurization on Nutrients and Biologically-Active Components in Donor Human Milk: A Review. Nutrients 2016, 8, 477. [Google Scholar] [CrossRef] [Green Version]
- Daniels, B.; Coutsoudis, A.; Autran, C.; Mansen, K.; Israel-Ballard, K.; Bode, L. The Effect of Simulated Flash Heating Pasteurisation and Holder Pasteurisation on Human Milk Oligosaccharides. Paediatr. Int. Child. Health 2017, 37, 204–209. [Google Scholar] [CrossRef]
- Nessel, I.; Khashu, M.; Dyall, S.C. The Effects of Storage Conditions on Long-Chain Polyunsaturated Fatty Acids, Lipid Mediators, and Antioxidants in Donor Human Milk—A Review. Prostaglandins Leukot. Essent. Fat. Acids 2019, 149, 8–17. [Google Scholar] [CrossRef]
- Paulaviciene, I.J.; Liubsys AEidukaite, A.; Molyte, A.; Tamuliene, L.; Usonis, V. The Effect of Prolonged Freezing and Holder Pasteurization on the Macronutrient and Bioactive Protein Compositions of Human Milk. Breastfeed. Med. 2020, 15, 583–588. [Google Scholar] [CrossRef]
- Koh, J.; Victor, A.F.; Howell, M.L.; Yeo, J.G.; Qu, Y.; Selover, B.; Waite-Cusic, J.; Dallas, D.C. Bile Salt-Stimulated Lipase Activity in Donor Breast Milk Influenced by Pasteurization Techniques. Front. Nutr. 2020, 7, 552362. [Google Scholar] [CrossRef]
- Gomes, F.P.; Shaw, P.N.; Whitfield, K.; Koorts, P.; McConachy, H.; Hewavitharana, A.K. Effect of Pasteurisation on the Concentrations of Vitamin D Compounds in Donor Breastmilk. Int. J. Food Sci. Nutr. 2015, 67, 16–19. [Google Scholar] [CrossRef] [PubMed]
- Wesołowska, A.; Sinkiewicz-Darol, E.; Barbarska, O.; Bernatowicz-Łojko, U.; Borszewska-Kornacka, M.K.; Van Goudoever, J.B. Innovative Techniques of Processing Human Milk to Preserve Key Components. Nutrients 2019, 11, 1169. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Maschmann, J.; Müller, D.; Lazar, K.; Goelz, R.; Hamprecht, K. New short-term heat inactivation method of cytomegalovirus (CMV) in breast milk: Impact on CMV inactivation, CMV antibodies and enzyme activities. Arch. Dis. Child. Fetal Neonatal Ed. 2019, 104, F604–F608. [Google Scholar] [CrossRef] [PubMed]
- Bapistella, S.; Hamprecht, K.; Thomas, W.; Speer, C.P.; Dietz, K.; Maschmann, J.; Poets, C.F.; Goelz, R. Short-term Pasteurization of Breast Milk to Prevent Postnatal Cytomegalovirus Transmission in Very Preterm Infants. Clin. Infect. Dis. 2019, 69, 438–444. [Google Scholar] [CrossRef]
- Escuder-Vieco, D.; Espinosa-Martos, I.; Rodríguez, J.M.; Corzo, N.; Montilla, A.; Siegfried, P.; Pallás-Alonso, C.R.; Fernández, L. High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting. Front. Microbiol. 2018, 9, 926. [Google Scholar] [CrossRef]
- Escuder-Vieco, D.; Espinosa-Martos, I.; Rodríguez, J.M.; Fernández, L.; Pallás-Alonso, C.R. Effect of HTST and Holder Pasteurization on the Concentration of Immunoglobulins, Growth Factors, and Hormones in Donor Human Milk. Front. Immunol. 2018, 9, 2222. [Google Scholar] [CrossRef] [Green Version]
- Escuder-Vieco, D.; Rodríguez, J.M.; Espinosa-Martos, I.; Corzo, N.; Montilla, A.; García-Serrano, A.; Calvo, M.V.; Fontecha, J.; Serrano, J.; Fernández, L. High-Temperature Short-Time and Holder Pasteurization of Donor Milk: Impact on Milk Composition. Life 2021, 11, 114. [Google Scholar] [CrossRef]
- Ben-Shoshan, M.; Mandel, D.; Lubetzky, R.; Dollberg, S.; Mimouni, F.B. Eradication of Cytomegalovirus from Human Milk by Microwave Irradiation: A Pilot Study. Breastfeed. Med. 2016, 11, 186–187. [Google Scholar] [CrossRef]
- Mikawa, T.; Mizuno, K.; Tanaka, K.; Kohda, C.; Ishii, Y.; Yamamoto, K.; Kobayashi, S. Microwave treatment of breast milk for prevention of cytomegalovirus infection. Pediatr. Int. 2019, 61, 1227–1231. [Google Scholar] [CrossRef]
- American Academy of Pediatrics; Workgroup on Breastfeeding. Breastfeeding and the use of human milk (RE9729). Pediatrics 1997, 100, 1035–1039. [Google Scholar] [CrossRef] [Green Version]
- Stagno, S.; Reynolds, D.W.; Pass, R.F.; Alford, C. Breast milk and the risk of cytomegalovirus infection. N. Engl. J. Med. 1980, 19, 1073–1076. [Google Scholar] [CrossRef] [PubMed]
- American Academy of Pediatrics. Human milk. In Red Book: 2018 Report of the Committee on Infectious Diseases, 31st ed.; Kimberlin, D.W., Brady, M.T., Jackson, M.A., Long, S.S., Eds.; American Academy of Pediatrics: Itasca, IL, USA, 2018; pp. 113–121. [Google Scholar]
- Parker, M.G.; Stellwagen, L.M.; Noble, L.; Kim, J.H.; Poindexter, B.B.; Puopolo, K.M.; Section on Breastfeeding; Committee on Nutrition; Committee on Fetus and Newborn. Promoting Human Milk and Breastfeeding for the Very Low Birth Weight Infant. Pediatrics 2021, 148, e2021054272. [Google Scholar] [CrossRef] [PubMed]
- Omarsdottir, S.; Casper, C.; Navér, L.; Legnevall, L.; Gustafsson, F.; Grillner, L.; Zweygberg-Wirgart, B.; Söderberg-Nauclér, C.; Vanpée, M. Cytomegalovirus infection and neonatal outcome in extremely preterm infants after freezing of maternal milk. Pediatr Infect. Dis. J. 2015, 34, 482–489. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Gunkel, J.; De Vries, L.S.; Jongmans, M.; Koopman-Esseboom, C.; Van Haastert, I.C.; Eijsermans, M.C.; Van Stam, C.; Van Zanten, B.G.; Wolfs, T.F.; Nijman, J. Outcome of preterm infants with postnatal cytomegalovirus infection. Pediatrics 2018, 141, e20170635. [Google Scholar] [CrossRef] [Green Version]
- Schleiss, M.R. Breast Milk–Acquired Cytomegalovirus in Premature Infants Uncertain Consequences and Unsolved Biological Questions. JAMA Pediatr. 2020, 174, 121–123. [Google Scholar] [CrossRef]
- Garofoli, F.; Civardi, E.; Zanette, S.; Angelini, M.; Perotti, G.; Zecca, M.; Lombardi, G. Literature Review and an Italian Hospital Experience about Post-Natal CMV Infection Acquired by Breast-Feeding in Very Low and/or Extremely Low Birth Weight Infants. Nutrients 2021, 13, 660. [Google Scholar] [CrossRef]
- Hamprecht, K.; Goelz, R. Postnatal Cytomegalovirus Infection through Human Milk in Preterm Infants: Transmission, Clinical Presentation, and Prevention. Clin. Perinatol. 2017, 44, 121–130. [Google Scholar] [CrossRef]
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Resch, B. How to Provide Breast Milk for the Preterm Infant and Avoid Symptomatic Cytomegalovirus Infection with Possible Long-Term Sequelae. Life 2022, 12, 504. https://doi.org/10.3390/life12040504
Resch B. How to Provide Breast Milk for the Preterm Infant and Avoid Symptomatic Cytomegalovirus Infection with Possible Long-Term Sequelae. Life. 2022; 12(4):504. https://doi.org/10.3390/life12040504
Chicago/Turabian StyleResch, Bernhard. 2022. "How to Provide Breast Milk for the Preterm Infant and Avoid Symptomatic Cytomegalovirus Infection with Possible Long-Term Sequelae" Life 12, no. 4: 504. https://doi.org/10.3390/life12040504