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Review

Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands—A Meta-Narrative Review

1
Department of Surgery, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
2
TRACER EUROPE BV, L.J. Zielstraweg 1, 9713 GX Groningen, The Netherlands
3
Department of Surgery, Martini Hospital Groningen, Van Swietenplein 1, 9728 NT Groningen, The Netherlands
4
Faculty Campus Fryslân, University of Groningen, Wirdumerdijk 34, 8911 CE Leeuwarden, The Netherlands
5
LIMIS Development BV, Henri Dunantweg 2, 8934 AD Leeuwarden, The Netherlands
6
Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editors: Joost R. van der Vorst and Alexander Vahrmeijer
Life 2022, 12(3), 388; https://doi.org/10.3390/life12030388
Received: 21 January 2022 / Revised: 1 March 2022 / Accepted: 6 March 2022 / Published: 8 March 2022
(This article belongs to the Special Issue Recent Advances and Applications of Image-Guided Surgery)
Background: Postoperative hypoparathyroidism is the most common complication after total thyroidectomy. Over the past years, optical imaging techniques, such as parathyroid autofluorescence, indocyanine green (ICG) angiography, and laser speckle contrast imaging (LSCI) have been employed to save parathyroid glands during thyroid surgery. This study provides an overview of the utilized methods of the optical imaging techniques during total thyroidectomy for parathyroid gland identification and preservation. Methods: PUBMED, EMBASE and Web of Science were searched for studies written in the English language utilizing parathyroid autofluorescence, ICG-angiography, or LSCI during total thyroidectomy to support parathyroid gland identification or preservation. Case reports, reviews, meta-analyses, animal studies, and post-mortem studies were excluded after the title and abstract screening. The data of the studies were analyzed qualitatively, with a focus on the methodologies employed. Results: In total, 59 articles were included with a total of 6190 patients. Overall, 38 studies reported using parathyroid autofluorescence, 24 using ICG-angiography, and 2 using LSCI. The heterogeneity between the utilized methodology in the studies was large, and in particular, regarding study protocols, imaging techniques, and the standardization of the imaging protocol. Conclusion: The diverse application of optical imaging techniques and a lack of standardization and quantification leads to heterogeneous conclusions regarding their clinical value. Worldwide consensus on imaging protocols is needed to establish the clinical utility of these techniques for parathyroid gland identification and preservation. View Full-Text
Keywords: optical imaging; fluorescence; thyroidectomy; parathyroid glands; hypoparathyroidism; near-infrared imaging; autofluorescence; indocyanine green angiography; laser speckle contrast imaging optical imaging; fluorescence; thyroidectomy; parathyroid glands; hypoparathyroidism; near-infrared imaging; autofluorescence; indocyanine green angiography; laser speckle contrast imaging
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MDPI and ACS Style

Feitsma, E.A.; Schouw, H.M.; Noltes, M.E.; Heeman, W.; Kelder, W.; van Dam, G.M.; Kruijff, S. Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands—A Meta-Narrative Review. Life 2022, 12, 388. https://doi.org/10.3390/life12030388

AMA Style

Feitsma EA, Schouw HM, Noltes ME, Heeman W, Kelder W, van Dam GM, Kruijff S. Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands—A Meta-Narrative Review. Life. 2022; 12(3):388. https://doi.org/10.3390/life12030388

Chicago/Turabian Style

Feitsma, Eline A., Hugo M. Schouw, Milou E. Noltes, Wido Heeman, Wendy Kelder, Gooitzen M. van Dam, and Schelto Kruijff. 2022. "Heterogeneity in Utilization of Optical Imaging Guided Surgery for Identifying or Preserving the Parathyroid Glands—A Meta-Narrative Review" Life 12, no. 3: 388. https://doi.org/10.3390/life12030388

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