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Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products

1
School of Dentistry, National and Kapodistrian University of Athens, Goudi, 11527 Athens, Greece
2
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Goudi, 11527 Athens, Greece
*
Author to whom correspondence should be addressed.
Academic Editors: Lei Wan and Fabrizio Montecucco
Life 2022, 12(2), 218; https://doi.org/10.3390/life12020218
Received: 22 December 2021 / Revised: 19 January 2022 / Accepted: 28 January 2022 / Published: 30 January 2022
(This article belongs to the Section Medical Research)
Advanced Glycation End Products (AGEs), the products of the non-enzymatic oxidation of proteins, nucleic acids, and lipids, are accumulated in periodontal tissues under hyperglycemic conditions such as Diabetes Mellitus (DM) and are responsible for sustained periodontal destruction. AGEs mediate their intracellular effects either directly or indirectly through receptor binding (via RAGE) in all types of periodontal ligament cells (osteocytes, gingival fibroblasts, stem cells, epithelial cells), indicating an important target for intervention. In combination with lipopolysaccharides (LPS) from Porphyromonas gingivalis (Pg), the negative impact of AGEs on periodontal tissue is further enhanced and accentuated. In addition, AGE accumulation is evident in peri-implantitis, yet through different underlying molecular mechanisms. Novel therapeutic approaches targeting the effects of AGEs in periodontal ligament cells show beneficial effects in pre-clinical studies. Herein, we provide evidence on the detrimental role of AGE accumulation in oral cavity tissues and their associated signaling pathways in periodontitis and peri-implantitis to further highlight the significance of oral or topical use of AGE blockers or inhibitors along with dental biofilms’ removal and DM regulation in patients’ management. View Full-Text
Keywords: AGEs; periodontitis; RAGE; peri-implantitis; inflammation; PDL cells; therapy; diabetes AGEs; periodontitis; RAGE; peri-implantitis; inflammation; PDL cells; therapy; diabetes
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MDPI and ACS Style

Plemmenos, G.; Piperi, C. Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products. Life 2022, 12, 218. https://doi.org/10.3390/life12020218

AMA Style

Plemmenos G, Piperi C. Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products. Life. 2022; 12(2):218. https://doi.org/10.3390/life12020218

Chicago/Turabian Style

Plemmenos, Grigorios, and Christina Piperi. 2022. "Pathogenic Molecular Mechanisms in Periodontitis and Peri-Implantitis: Role of Advanced Glycation End Products" Life 12, no. 2: 218. https://doi.org/10.3390/life12020218

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