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Article

Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression

1
Laureate Institute for Brain Research, Tulsa, OK 74136, USA
2
Oxley College of Health Sciences, The University of Tulsa, Tulsa, OK 74119, USA
3
Department of Aging Research and Geriatric Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan
4
Department of Geriatric Medicine and Neuroimaging, Tohoku University Hospital, Sendai 980-8574, Japan
5
Smart-Aging Research Center, Tohoku University, Sendai 980-8575, Japan
6
Department of Surgery, University of Oklahoma School of Community Medicine, Tulsa, OK 74135, USA
7
Department of Psychiatry, University of Oklahoma School of Community Medicine, Tulsa, OK 74135, USA
8
Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, USA
9
Cousins Center for Psychoneuroimmunology at UCLA, Los Angeles, CA 90095, USA
10
Semel Institute for Neuroscience at UCLA, Los Angeles, CA 90024, USA
11
David Geffen School of Medicine, Los Angeles, CA 90095, USA
12
Department of Neurological Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15260, USA
*
Author to whom correspondence should be addressed.
The list of Tulsa 1000 Investigators is provided in the Acknowledgments.
Academic Editors: Shuhei Yamaguchi and Keiichi Onoda
Life 2022, 12(1), 43; https://doi.org/10.3390/life12010043
Received: 25 November 2021 / Revised: 17 December 2021 / Accepted: 22 December 2021 / Published: 28 December 2021
(1) Background: Growing evidence indicates that inflammation can induce neural circuit dysfunction and plays a vital role in the pathogenesis of major depressive disorder (MDD). Nevertheless, whether inflammation affects the integrity of white matter pathways is only beginning to be explored. (2) Methods: We computed quantitative anisotropy (QA) from diffusion magnetic resonance imaging as an index of white matter integrity and regressed QA on C-reactive protein (CRP), controlling for age, sex, and BMI, in 176 participants with MDD. (3) Results: The QA values of several white matter tracts were negatively correlated with CRP concentration (standardized beta coefficient = −0.22, 95%CI = −0.38–−0.06, FDR < 0.05). These tracts included the bilateral cortico-striatal tracts, thalamic radiations, inferior longitudinal fasciculi, corpus callosum (the forceps minor portion and the tapetum portion), cingulum bundles, and the left superior longitudinal fasciculus III. Importantly, the association remained robust after regressing up to twelve potential confounders. The bilateral fornix and a small portion of the thalamic radiation showed a positive association with CRP levels, but these associations did not remain significant after adjusting for confounders. (4) Conclusions: Peripheral inflammation may contribute to the etiology of MDD by impacting the microstructural integrity of brain corticolimbic white matter pathways. View Full-Text
Keywords: CRP; MDD; white matter integrity; quantitative anisotropy; connectometry analysis; diffusion MRI CRP; MDD; white matter integrity; quantitative anisotropy; connectometry analysis; diffusion MRI
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MDPI and ACS Style

Thomas, M.; Savitz, J.; Zhang, Y.; Burrows, K.; Smith, R.; Figueroa-Hall, L.; Kuplicki, R.; Khalsa, S.S.; Taki, Y.; Teague, T.K.; Irwin, M.R.; Yeh, F.-C.; Paulus, M.P.; Zheng, H.; on behalf of Tulsa 1000 Investigators. Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life 2022, 12, 43. https://doi.org/10.3390/life12010043

AMA Style

Thomas M, Savitz J, Zhang Y, Burrows K, Smith R, Figueroa-Hall L, Kuplicki R, Khalsa SS, Taki Y, Teague TK, Irwin MR, Yeh F-C, Paulus MP, Zheng H, on behalf of Tulsa 1000 Investigators. Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life. 2022; 12(1):43. https://doi.org/10.3390/life12010043

Chicago/Turabian Style

Thomas, MacGregor, Jonathan Savitz, Ye Zhang, Kaiping Burrows, Ryan Smith, Leandra Figueroa-Hall, Rayus Kuplicki, Sahib S. Khalsa, Yasuyuki Taki, Tracy Kent Teague, Michael R. Irwin, Fang-Cheng Yeh, Martin P. Paulus, Haixia Zheng, and on behalf of Tulsa 1000 Investigators. 2022. "Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression" Life 12, no. 1: 43. https://doi.org/10.3390/life12010043

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