Genetic Investigation of Inverse Psoriasis
Abstract
:1. Introduction
2. Materials and Methods
2.1. Patients
2.2. Blood Samples
2.3. DNA Isolation
2.4. Library Preparation and Exome Sequencing
2.5. Data Analysis
3. Results
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Variant ID | Location | Gene | Variant Effect | cDNA | Protein | MAF | Transcript | Domain | |
---|---|---|---|---|---|---|---|---|---|
rs1250209 | chr2:216235089 | FN1 | fibronectin 1 | Missense | c.6781G > A | p.Val2261Ile | <0.01 | NM_212482.2 | Fibronectin type 1 |
rs136730 | chr22:45923827 | FBLN1 | fibulin 1 | Missense | c.422A > G | p.Gln141Arg | <0.01 | NM_006486.2 | Anaphylatoxin homologous |
rs2425015 | chr20:33583331 | MYH7B | myosin heavy chain 7B | Missense | c.3019A > G | p.Lys1007Glu | <0.01 | NM_020884.4 | Coiled coil |
rs4930409 | chr11:66837965 | RHOD | ras homolog family member D | Missense | c.400T > C | p.Cys134Arg | <0.01 | NM_014578.3 | RHO |
rs6599241 | chr3:38739574 | SCN10A | sodium voltage-gated channel alpha subunit 10 | Missense | c.5137A > G | p.Met1713Val | <0.01 | NM_006514.3 | Transmembrane |
rs7433231 | chr3:49928691 | MST1R | macrophage stimulating 1 receptor | Missense | c.3583A > G | p.Ser1195Gly | <0.01 | NM_002447.3 | Tyrosine kinase, catalytic |
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Göblös, A.; Varga, E.; Farkas, K.; Árvai, K.; Kemény, L. Genetic Investigation of Inverse Psoriasis. Life 2021, 11, 654. https://doi.org/10.3390/life11070654
Göblös A, Varga E, Farkas K, Árvai K, Kemény L. Genetic Investigation of Inverse Psoriasis. Life. 2021; 11(7):654. https://doi.org/10.3390/life11070654
Chicago/Turabian StyleGöblös, Anikó, Emese Varga, Katalin Farkas, Kristóf Árvai, and Lajos Kemény. 2021. "Genetic Investigation of Inverse Psoriasis" Life 11, no. 7: 654. https://doi.org/10.3390/life11070654