Clinical Markers of Chronic Hypoxemia in Respiratory Patients Residing at Moderate Altitude
Abstract
:1. Introduction
2. Materials and Methods
2.1. Serum Protein Determination
2.2. Ancestry Informative Markers (AIMs) Genotyping
2.3. Statistical Analysis
3. Results
3.1. Protein Measurements
3.1.1. Correlation Analysis
3.1.2. Ancestral Contribution According to AIMs
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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COPD | OSA | ILD | Controls | |
---|---|---|---|---|
Sex (M|F) | 12|8 | 27|12 | 1|1 | 44|26 |
Age (years) | 68 (63–71) | 53 (42–57) | 64 (62–63) | 56 (45–69) |
BMI (kg/m2) | 24.50 (22.23–27.25) | 39 (36.50–44.50) | 24 (23–28) | 26 (24–28.15) |
Pulse Oximetry (%) | 89 (87–91) | 88 (87–90) | 94 (93-94) | 94 (93.25–95.90) |
PaO2 (mmHg) | 54.95 (51.25–56.40) | 53.95 (49.67–56.77) | 47.90 (47.70–55.60) | NT |
SpO2 (%) | 88 (86–88) | 87 (77–88) | 85 (77–87) | NT |
SaO2 (%) | 87.47 (84.47–88.78) | 86.90 (84.79–88.35) | 83.90 (82.10–85.00) | NT |
FEV1 (%) | 48 (46.50–64.50) | 81.5 (72.75–94.0) | 61 (39.5–83.5) | 108 (98–117) |
FVC (%) | 79 (72.50–96.50) | 88 (76–94) | 54.50 (37.00–72.75) | 112.50 (97.25–119.75) |
DLCO (%) | 82.50 (64.75–104.50) | 123 (103–139.8) | 45 (39–46) | 113.5 (105.8–127) |
Basal | Follow Up | p-Value | ||
---|---|---|---|---|
HIF1A | 0.270 | |||
COPD | 146.5 (0–2917.1) | 39.62 (0–491.03) | 0.324 | |
OSA | 125.0 (0–3071.8)) | 71.96 (0–1260.26) | 0.389 | |
ILD | 384.87 (0–1917.95) | 526.3 (263.1–789.4) | 0.665 | |
VEGF | 0.677 | |||
COPD | 216.07 (78.83–328.81) | 192.47 (83.36–331.61) | 0.331 | |
OSA | 342.0 (78–457.20) | 350.4 (104.1–464.1) | 0.678 | |
ILD | 12.6 (1.1–137.46) | 83.36 (48.13–118.59) | 0.809 | |
EPO | 0.033 | |||
COPD | 12.39 (4.19–21.98) | 9.44 (2.93–14.19) | 0.023 | |
OSA | 16.80 (7.96–32.56) | 9.20 (4.04–19.01) | 0.025 | |
ILD | 20.72 (10.62–21.04) | 21.98 (18.98–24.98) | 0.809 |
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Fernández-Plata, R.; Thirion-Romero, I.; Nava-Quiroz, K.J.; Pérez-Rubio, G.; Rodríguez-Llamazares, S.; Pérez-Kawabe, M.; Rodríguez-Reyes, Y.; Guerrero-Zuñiga, S.; Orea-Tejeda, A.; Falfán-Valencia, R.; et al. Clinical Markers of Chronic Hypoxemia in Respiratory Patients Residing at Moderate Altitude. Life 2021, 11, 428. https://doi.org/10.3390/life11050428
Fernández-Plata R, Thirion-Romero I, Nava-Quiroz KJ, Pérez-Rubio G, Rodríguez-Llamazares S, Pérez-Kawabe M, Rodríguez-Reyes Y, Guerrero-Zuñiga S, Orea-Tejeda A, Falfán-Valencia R, et al. Clinical Markers of Chronic Hypoxemia in Respiratory Patients Residing at Moderate Altitude. Life. 2021; 11(5):428. https://doi.org/10.3390/life11050428
Chicago/Turabian StyleFernández-Plata, Rosario, Ireri Thirion-Romero, Karol J. Nava-Quiroz, Gloria Pérez-Rubio, Sebastián Rodríguez-Llamazares, Midori Pérez-Kawabe, Yadira Rodríguez-Reyes, Selene Guerrero-Zuñiga, Arturo Orea-Tejeda, Ramcés Falfán-Valencia, and et al. 2021. "Clinical Markers of Chronic Hypoxemia in Respiratory Patients Residing at Moderate Altitude" Life 11, no. 5: 428. https://doi.org/10.3390/life11050428