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Article

Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear

1
MED-EL Research Center, 30625 Hannover, Germany
2
Department of Otolaryngology, Hannover Medical School, 30625 Hannover, Germany
3
MED-EL Medical Electronics, 6020 Innsbruck, Austria
*
Author to whom correspondence should be addressed.
These authors contributed equally to the study.
Academic Editor: Arianna Di Stadio
Life 2021, 11(5), 373; https://doi.org/10.3390/life11050373
Received: 29 March 2021 / Revised: 15 April 2021 / Accepted: 20 April 2021 / Published: 21 April 2021
(This article belongs to the Section Medical Research)
In the field of cochlear implantation, artificial/physical models of the inner ear are often employed to investigate certain phenomena like the forces occurring during implant insertions. Up to now, no such models are available for the analysis of diffusion processes inside the cochlea although drug delivery is playing an increasingly important role in this field. For easy access of the cochlea along its whole profile, e.g., for sequential sampling in an experimental setting, such a model should ideally be longitudinal/uncoiled. Within this study, a set of 15 micro-CT imaging datasets of human cochleae was used to derive an average representation of the scala tympani. The spiral profile of this model was then uncoiled along different trajectories, showing that these trajectories influence both length and volume of the resulting longitudinal model. A volumetric analysis of the average spiral model was conducted to derive volume-to-length interrelations for the different trajectories, which were then used to generate two tubular, longitudinal scala tympani models with volume and length properties matching the original, spiral profile. These models can be downloaded for free and used for reproducible and comparable simulative and experimental investigations of diffusion processes within the inner ear. View Full-Text
Keywords: cochlear implantation; cochlear models; cochlear volume; drug delivery cochlear implantation; cochlear models; cochlear volume; drug delivery
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MDPI and ACS Style

Schurzig, D.; Fröhlich, M.; Raggl, S.; Scheper, V.; Lenarz, T.; Rau, T.S. Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear. Life 2021, 11, 373. https://doi.org/10.3390/life11050373

AMA Style

Schurzig D, Fröhlich M, Raggl S, Scheper V, Lenarz T, Rau TS. Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear. Life. 2021; 11(5):373. https://doi.org/10.3390/life11050373

Chicago/Turabian Style

Schurzig, Daniel, Max Fröhlich, Stefan Raggl, Verena Scheper, Thomas Lenarz, and Thomas S. Rau. 2021. "Uncoiling the Human Cochlea—Physical Scala Tympani Models to Study Pharmacokinetics Inside the Inner Ear" Life 11, no. 5: 373. https://doi.org/10.3390/life11050373

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