Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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All Patients (n = 83) | |
---|---|
Sex, Male, n (%) Age (years) | 60 (72.3) 59.6 ± 10.9 |
BMI (kg/m2) | 30.0 ± 5.6 |
Waist-to-hip ratio | 0.99 ± 0.07 |
PASI | 3.5 (1.1–10.8) |
PsA, n (%) | 20 (24.1) |
Medically treated hypertension, n (%) | 36 (43.4) |
Medically treated diabetes, n (%) | 20 (24.1) |
Systemic antipsoriatic treatment, n (%) | 44 (53.0) |
Statin treatment, n (%) | 41 (49.4) |
Prior CVD, n (%) | 39 (47.0) |
Smoking, present or previous, n (%) | 61 (73.5) |
HbA1c (mmol/mol) | 36.0 (34.0–41.0) |
Total cholesterol (mmol/L) | 4.43 ± 0.98 |
LDL-C (mmol/L) | 2.39 ± 0.84 |
HDL-C (mmol/L) | 1.24 ± 0.38 |
Triglycerides (mmol/L) | 1.87 ± 0.97 |
Blood glucose (mmol/L) | 5.9 (5.4–6.7) |
hs-CRP (mg/L) | 1.41 (0.68–3.83) |
Entire aorta (TBRmax) | 2.27 ± 0.39 |
Visceral adipose tissue (TBRmean) | 0.17 (0.15–0.21) |
Subcutaneous adipose tissue (TBRmean) | 0.13 (0.11–0.16) |
Pericardial adipose tissue (TBRmean) | 0.34 (0.26–0.52) |
Spleen (SLRmean) | 0.94 ± 0.10 |
Bone marrow (BLRmean) | 1.00 ± 0.20 |
Carotid intima-media thickness (mm) | 0.73 ± 0.13 |
Carotid atherosclerotic plaques, n (%) | 50 (60.2) |
All Patients (n = 83) | No CVD (n = 44) | |
---|---|---|
β (p-Value) | β (p-Value) | |
Visceral adipose tissue 1 Unadjusted Adjusted | 0.26 (<0.001) 0.24 (0.001) | 0.29 (0.002) 0.27 (0.011) |
Subcutaneous adipose tissue 1 Unadjusted Adjusted | 0.28 (0.007) 0.34 (0.002) | 0.39 (0.010) 0.42 (0.011) |
Pericardial adipose tissue 1 Unadjusted Adjusted | 0.24 (<0.001) 0.32 (<0.001) | 0.32 (<0.001) 0.40 (<0.001) |
Spleen-to-liver ratio Unadjusted Adjusted | 1.35 (0.001) 1.44 (< 0.001) | 0.49 (0.491) 0.86 (0.262) |
Bone marrow-to-liver ratio Unadjusted Adjusted | 1.14 (<0.001) 1.19 (<0.001) | 1.24 (<0.001) 1.36 (<0.001) |
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Kaiser, H.; Kvist-Hansen, A.; Krakauer, M.; Gørtz, P.M.; Henningsen, K.M.A.; Wang, X.; Becker, C.; Zachariae, C.; Skov, L.; Hansen, P.R. Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis. Life 2021, 11, 305. https://doi.org/10.3390/life11040305
Kaiser H, Kvist-Hansen A, Krakauer M, Gørtz PM, Henningsen KMA, Wang X, Becker C, Zachariae C, Skov L, Hansen PR. Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis. Life. 2021; 11(4):305. https://doi.org/10.3390/life11040305
Chicago/Turabian StyleKaiser, Hannah, Amanda Kvist-Hansen, Martin Krakauer, Peter Michael Gørtz, Kristoffer Mads Aaris Henningsen, Xing Wang, Christine Becker, Claus Zachariae, Lone Skov, and Peter Riis Hansen. 2021. "Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis" Life 11, no. 4: 305. https://doi.org/10.3390/life11040305
APA StyleKaiser, H., Kvist-Hansen, A., Krakauer, M., Gørtz, P. M., Henningsen, K. M. A., Wang, X., Becker, C., Zachariae, C., Skov, L., & Hansen, P. R. (2021). Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients with Psoriasis. Life, 11(4), 305. https://doi.org/10.3390/life11040305