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Article

Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts

Industrial Bio-materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
*
Authors to whom correspondence should be addressed.
Earlier known as Hua Li.
Academic Editor: Balazs Barna
Life 2021, 11(2), 147; https://doi.org/10.3390/life11020147
Received: 26 January 2021 / Revised: 12 February 2021 / Accepted: 13 February 2021 / Published: 15 February 2021
(This article belongs to the Section Pharmaceutical Science)
Pheophorbide a is a chlorophyll metabolic breakdown product. This study investigated the antiwrinkle effect of pheophorbide a (PA) and its derivatives, including pyropheophorbide a (PyroPA) and pyropheophorbide a methyl ester (PyroPA-ME), on ultraviolet (UV) B-stimulated CCD-986sk fibroblasts. PA, PyroPA, and PyroPA-ME effectively suppressed reactive oxygen species accumulation in UVB-exposed CCD-986sk fibroblasts. All three pheophorbides also reduced UVB-induced matrix metalloproteinase (MMP)-1 secretion and mRNA expression of MMP-1, MMP-2, and MMP-9. Treatment with pheophorbides resulted in increased procollagen synthesis, and this required enhancement of procollagen type I C-peptide content and mRNA expression of collagen type I alpha 1 (COL1A1) and COL1A2 in CCD-986sk cells. These antiwrinkle effects were more potent with PA and PyroPA than with PyroPA-ME. Furthermore, PA and PyroPA suppressed UVB-induced phosphorylation of extracellular signal-regulated protein kinase and c-Jun N-terminal kinase but not p38. Moreover, all three pheophorbides inhibited NF-κB p65 phosphorylation. Therefore, these pheophorbides, especially PA and PyroPA, can be used as antiwrinkle agents, and PA- or PyroPA-rich natural resources can be used in functional cosmetics. View Full-Text
Keywords: antiwrinkle; collagen; fibroblasts; pheophorbide a derivatives; matrix metalloproteinases antiwrinkle; collagen; fibroblasts; pheophorbide a derivatives; matrix metalloproteinases
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MDPI and ACS Style

Lee, H.; Park, H.-Y.; Jeong, T.-S. Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts. Life 2021, 11, 147. https://doi.org/10.3390/life11020147

AMA Style

Lee H, Park H-Y, Jeong T-S. Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts. Life. 2021; 11(2):147. https://doi.org/10.3390/life11020147

Chicago/Turabian Style

Lee, Hwa, Ho-Yong Park, and Tae-Sook Jeong. 2021. "Pheophorbide a Derivatives Exert Antiwrinkle Effects on UVB-Induced Skin Aging in Human Fibroblasts" Life 11, no. 2: 147. https://doi.org/10.3390/life11020147

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