Next Article in Journal
De Novo Transcriptome Profiling of Brain Tissue from the Annual Killifish Nothobranchius guentheri
Next Article in Special Issue
Neuron–Oligodendrocyte Communication in Myelination of Cortical GABAergic Cells
Previous Article in Journal
Blood Biomarkers to Predict Long-Term Mortality after Ischemic Stroke
Previous Article in Special Issue
Oligodendroglial Heterogeneity in Neuropsychiatric Disease
Open AccessArticle

New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea

1
Electron Microscopy Core Unit, Department of Neurogenetics, Max-Planck-Institute of Experimental Medicine, 37075 Göttingen, Germany
2
Cluster of Excellence Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells (MBExC), University of Göttingen, 37073 Göttingen, Germany
3
Eugene Bell Center for Regenerative Biology and Tissue Engineering, Marine Biological Laboratory, Woods Hole, MA 02540, USA
4
Whitman Science Center, Marin Biological Laboratory, Woods Hole, MA 02540, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Nathalie Sol-Foulon
Life 2021, 11(2), 136; https://doi.org/10.3390/life11020136
Received: 5 January 2021 / Revised: 2 February 2021 / Accepted: 6 February 2021 / Published: 11 February 2021
(This article belongs to the Special Issue Myelin and Oligodendrocyte-Neuron Interactions)
Although myelinated nervous systems are shared among 60,000 jawed vertebrates, studies aimed at understanding myelination have focused more and more on mice and zebrafish. To obtain a broader understanding of the myelination process, we examined the little skate, Leucoraja erinacea. The reasons behind initiating studies at this time include: the desire to study a species belonging to an out group of other jawed vertebrates; using a species with embryos accessible throughout development; the availability of genome sequences; and the likelihood that mammalian antibodies recognize homologs in the chosen species. We report that the morphological features of myelination in a skate hatchling, a stage that supports complex behavioral repertoires needed for survival, are highly similar in terms of: appearances of myelinating oligodendrocytes (CNS) and Schwann cells (PNS); the way their levels of myelination conform to axon caliber; and their identity in terms of nodal and paranodal specializations. These features provide a core for further studies to determine: axon–myelinating cell communication; the structures of the proteins and lipids upon which myelinated fibers are formed; the pathways used to transport these molecules to sites of myelin assembly and maintenance; and the gene regulatory networks that control their expressions. View Full-Text
Keywords: myelin evolution; little skate; oligodendrocytes; Schwann cells; elasmobranch; spinal cord; optic nerve; electron microscopy myelin evolution; little skate; oligodendrocytes; Schwann cells; elasmobranch; spinal cord; optic nerve; electron microscopy
Show Figures

Figure 1

MDPI and ACS Style

Möbius, W.; Hümmert, S.; Ruhwedel, T.; Kuzirian, A.; Gould, R. New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea. Life 2021, 11, 136. https://doi.org/10.3390/life11020136

AMA Style

Möbius W, Hümmert S, Ruhwedel T, Kuzirian A, Gould R. New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea. Life. 2021; 11(2):136. https://doi.org/10.3390/life11020136

Chicago/Turabian Style

Möbius, Wiebke; Hümmert, Sophie; Ruhwedel, Torben; Kuzirian, Alan; Gould, Robert. 2021. "New Species Can Broaden Myelin Research: Suitability of Little Skate, Leucoraja erinacea" Life 11, no. 2: 136. https://doi.org/10.3390/life11020136

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop