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Open AccessArticle

Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts

1
Department of Biomedical Science, Program in Biomedical Science & Engineering, Department of Kinesiology, Inha University, Incheon 22212, Korea
2
Institute of Sports and Arts Convergence, Inha University, Incheon 22212, Korea
3
Department of Pharmacology, College of Medicine, Inha University, Incheon 22212, Korea
4
Department of Physiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea
5
National Research Laboratory for Mitochondrial Signaling, Department of Physiology, College of Medicine, Cardiovascular and Metabolic Disease Center, Inje University, Busan 47392, Korea
*
Author to whom correspondence should be addressed.
Life 2020, 10(9), 178; https://doi.org/10.3390/life10090178
Received: 20 July 2020 / Revised: 16 August 2020 / Accepted: 4 September 2020 / Published: 5 September 2020
(This article belongs to the Special Issue Impaired Mitochondrial Bioenergetics under Pathological Conditions)
Aging represents a major risk for developing cardiac disease, including heart failure. The gradual deterioration of cell quality control with aging leads to cell death, a phenomenon associated with mitochondrial dysfunction in the heart. Apoptosis is an important quality control process and a necessary phenomenon for maintaining homeostasis and normal function of the heart. However, the mechanism of mitochondria-mediated apoptosis in aged hearts remains poorly understood. Here, we used male Fischer 344 rats of various ages, representing very young (1 month), young (4 months), middle-aged (12 months), and old (20 months) rats, to determine whether mitochondria-mediated apoptotic signals and apoptosis in the left ventricle of the heart are altered notably with aging. As the rats aged, the extramyocyte space and myocyte cross-sectional area in their left ventricle muscle increased, while the number of myocytes decreased. Additionally, mitochondrion-mediated apoptotic signals and apoptosis increased remarkably during aging. Therefore, our results demonstrate that aging promotes remarkable morphological changes and increases the degree of mitochondrion-mediated apoptosis in the left ventricle of rat hearts. View Full-Text
Keywords: aging heart; Bcl-2 family; mitochondria; programmed cell death aging heart; Bcl-2 family; mitochondria; programmed cell death
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No, M.-H.; Choi, Y.; Cho, J.; Heo, J.-W.; Cho, E.-J.; Park, D.-H.; Kang, J.-H.; Kim, C.-J.; Seo, D.Y.; Han, J.; Kwak, H.-B. Aging Promotes Mitochondria-Mediated Apoptosis in Rat Hearts. Life 2020, 10, 178.

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