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Article

High Variability of Postsurgical Anatomy Supports the Need for Individualized Drug-Eluting Implants to Treat Chronic Rhinosinusitis

1
Department of Otorhinolaryngology, Head and Neck Surgery, Lower Saxony Center for Biomedical Engineering, Implant Research and Development (NIFE), Hannover Medical School, 30625 Hannover, Germany
2
Cluster of Excellence ‘Hearing4all’ EXC 1077/1, 30625 Hannover, Germany
3
HörSys GmbH, 30625 Hannover, Germany
*
Author to whom correspondence should be addressed.
Life 2020, 10(12), 353; https://doi.org/10.3390/life10120353
Received: 9 November 2020 / Revised: 4 December 2020 / Accepted: 15 December 2020 / Published: 17 December 2020
Chronic rhinosinusitis (CRS) is a common disease in the general population that is increasing in incidence and prevalence, severely affecting patients’ quality of life. Medical treatment for CRS includes self-management techniques, topical and oral medical treatments, and functional endoscopic sinus surgery (FESS). FESS is a standard procedure to restore sinus ventilation and drainage by physically enlarging the inflamed sinus passageways. Nasal drug-releasing stents are implanted to keep the surgically expanded aperture to the sinus frontalis open. The outcome of such an intervention is highly variable. We defined the anatomical structures which should be removed, along with ‘no-go areas’ which need to be preserved during FESS. Based on these definitions, we used cone beam computed tomography (CBCT) images to measure the dimensions of the frontal neo-ostium in 22 patients. We demonstrate anatomical variability in the volume and diameter of the frontal sinus recess after surgery. This variability could be the cause of therapy failure of drug-eluting implants after FESS in some patients. Implants individually made to fit a given patient’s postsurgical anatomy may improve the therapeutic outcome. View Full-Text
Keywords: endoscopic sinus surgery; sinus anatomy; drug delivery; nasal implant; individualized frontal neo-ostium implant endoscopic sinus surgery; sinus anatomy; drug delivery; nasal implant; individualized frontal neo-ostium implant
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MDPI and ACS Style

Gao, Z.; Matin, F.; Weber, C.; John, S.; Lenarz, T.; Scheper, V. High Variability of Postsurgical Anatomy Supports the Need for Individualized Drug-Eluting Implants to Treat Chronic Rhinosinusitis. Life 2020, 10, 353. https://doi.org/10.3390/life10120353

AMA Style

Gao Z, Matin F, Weber C, John S, Lenarz T, Scheper V. High Variability of Postsurgical Anatomy Supports the Need for Individualized Drug-Eluting Implants to Treat Chronic Rhinosinusitis. Life. 2020; 10(12):353. https://doi.org/10.3390/life10120353

Chicago/Turabian Style

Gao, Ziwen, Farnaz Matin, Constantin Weber, Samuel John, Thomas Lenarz, and Verena Scheper. 2020. "High Variability of Postsurgical Anatomy Supports the Need for Individualized Drug-Eluting Implants to Treat Chronic Rhinosinusitis" Life 10, no. 12: 353. https://doi.org/10.3390/life10120353

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