Both Tumor Necrosis Factor Receptor Signaling Pathways Contribute to Mortality but not to Splenomegaly in Generalized Lymphoproliferative Disorder
Abstract
:1. Introduction
2. Results and Discussion
2.1. Comparison of the Overall Phenotype of B6.gld.TNFR1−/− and B6.gld.TNFR2−/− Mice
2.2. Transfer of CD4−/CD8− DN T Cells into TNFR Double Knockouts Follows the Respective TNFR Phenotype and Results in Migration to the Bridging Channels or Ends in the B Cell Area
3. Experimental Section
3.1. Mouse Strains
3.2. Ethics Statement
3.3. CCL21 Elisa
3.4. Fluorescence Immunohistology
3.5. Flow Cytometry
3.6. Adoptive Cell Transfer
4. Conclusions
Acknowledgments
Author Contributions
Conflicts of Interest
References
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Wiede, F.; Roomberg, A.; Darby, J.; Gollan, R.; Körner, H. Both Tumor Necrosis Factor Receptor Signaling Pathways Contribute to Mortality but not to Splenomegaly in Generalized Lymphoproliferative Disorder. Antibodies 2015, 4, 1-10. https://doi.org/10.3390/antib4010001
Wiede F, Roomberg A, Darby J, Gollan R, Körner H. Both Tumor Necrosis Factor Receptor Signaling Pathways Contribute to Mortality but not to Splenomegaly in Generalized Lymphoproliferative Disorder. Antibodies. 2015; 4(1):1-10. https://doi.org/10.3390/antib4010001
Chicago/Turabian StyleWiede, Florian, Alicia Roomberg, Jocelyn Darby, Rene Gollan, and Heinrich Körner. 2015. "Both Tumor Necrosis Factor Receptor Signaling Pathways Contribute to Mortality but not to Splenomegaly in Generalized Lymphoproliferative Disorder" Antibodies 4, no. 1: 1-10. https://doi.org/10.3390/antib4010001