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Review

Antiphospholipid Antibodies Associated with Native Arteriovenous Fistula Complications in Hemodialysis Patients: A Comprehensive Review of the Literature

by
Maxime Taghavi
1,2,*,
Abla Jabrane
1,
Lucas Jacobs
1,
Maria Do Carmo Filomena Mesquita
1,
Anne Demulder
3,† and
Joëlle Nortier
1,2,†
1
Nephrology and Dialysis Department, Brugmann University Hospital, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium
2
Laboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles (ULB), 1070 Brussels, Belgium
3
Laboratory of Hematology and Haemostasis LHUB-ULB, Brugmann University Hospital, Université Libre de Bruxelles (ULB), 1020 Brussels, Belgium
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Antibodies 2024, 13(1), 1; https://doi.org/10.3390/antib13010001
Submission received: 30 October 2023 / Revised: 18 December 2023 / Accepted: 20 December 2023 / Published: 2 January 2024
(This article belongs to the Special Issue Autoimmune and Inflammatory Rheumatic Diseases: Potential Biomarkers, Antibodies Response and New Therapies)
Browse Figure
Versions Notes

Abstract

:
Antiphospholipid antibody (aPL)-persistent positivity is frequent in hemodialysis (HD) patients. Native arteriovenous fistula (AVF) complications such as stenosis and thrombosis are among the most important causes of morbidity and mortality in hemodialysis patients. The association between aPL positivity and AVF thrombosis seems to now be well established. However, whether aPL positivity is associated with other AVF complications, such as maturation failure or stenosis, is not well known. Given the significant impact of AVF failure on patient’s prognosis, it is of interest to further investigate this particular point in order to improve prevention, surveillance and treatment, and, ultimately, the patient’s outcome. This literature review aims to report the recent literature on aPL-associated native AVF complications.

1. Introduction

1.1. Hemodialysis and Vascular Access

End-stage kidney disease (ESKD) is typically defined by a glomerular filtration rate of less than 15 mL/min/1.73 m2 and requires the initiation of renal replacement therapy, such as hemodialysis (HD), peritoneal dialysis, or kidney transplantation, for survival [1]. The incidence of ESKD is increasing worldwide and the large majority of the patients remain on chronic HD, a modality requiring an efficient vascular access. The options for vascular access in HD patients include native arteriovenous fistulas (AVF), arteriovenous grafts (AVG), and tunneled central venous catheters (CVC). Native AVF is generally considered as the best option for vascular access in HD patients, because of lower rates of infection and thrombosis compared to AVG and CVC. Additionally, AVF have been associated with improved long-term survival and reduced healthcare costs [2,3]. However, AVF complications are common in HD patients and can lead to significant morbidity and mortality. These complications include thrombosis, stenosis, infection, aneurysm, pseudoaneurysm, and hemorrhage. Thrombosis and stenosis are the most common complications, often requiring intervention with angioplasty or thrombectomy. Regular monitoring and timely intervention can help prevent and manage these complications [4].

1.2. Antiphospholipid Syndrome and Pathophysiology

Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the persistent positivity of circulating antiphospholipid antibodies (aPL) resulting in arterial, venous, or microvascular thrombosis and obstetrical complications. The pathophysiology of thrombosis in APS is complex and multifactorial. aPL trigger phospholipids and phospholipid binding proteins at different cell surfaces (i.e., endothelial cell, platelets, monocytes, and neutrophils). Endothelial cells are activated by aPL and acquire a phenotype that promotes inflammation, complement activation, leukocyte trafficking, and a procoagulant state. This activation ultimately leads to in situ thrombosis while also promoting other non-thrombotic autoimmune and inflammatory complications [5,6]. APS have also been associated with endothelial cell dysfunction both in vitro and in vivo [7,8]. Distinct from thrombotic events, the chronic occlusive APS vasculopathy is characterized by cell proliferation and infiltration that progressively expands the intima, therefore narrowing the vascular lumen. The latter was first described in aPL nephropathy [9]. The mammalian Target of Rapamycin (mTOR) pathway, implicated in cell proliferation and survival, seems to be an important signaling pathway by which aPL trigger intimal hyperplasia and occlusive vasculopathy [6,10].
A “two-hit” model in the pathogenesis of APS has been proposed, postulating that aPL provide the first hit favoring a procoagulant state but not sufficient to cause thrombosis. Subsequently, a second hit (e.g., an infectious or inflammatory stimuli or a vascular injury) will lead to vascular thrombosis. This second hit is not obvious in many cases [6].

1.3. Classification Criteria of Antiphospholipid Syndrome

The 2006 Revised Sapporo APS classification criteria have been recently revised in 2023 by the American College of Rheumatology (ACR) and the European Alliance of Associations for Rheumatology (EULAR) [11,12]. These new classification criteria are based on a scoring system for both laboratory and clinical criteria. Patients can be classified as APS for research purposes if there are at least 3 points from clinical domains and at least 3 points from laboratory domains. As in the previous criteria, aPL positivity must be confirmed after at least 12 weeks. Three aPL assays are recommended, including Immunoglobulin (Ig) G or IgM anticardiolipin antibody (aCL), IgG or IgM anti-beta2 glycoprotein I antibody (aβ2-GPI), or Lupus Anticoagulant (LA). The 2023 ACR/EULAR classification criteria no longer consider isolated positivity of IgM aCL or IgM aβ2-GPI as sufficient [11,12]. Other non-criteria antibodies potentially predictive of thrombosis in APS such as IgA aCL; IgA aβ2-GPI; IgG, IgA, IgM anti-phosphatidylserine/prothrombin (aPS/PT); IgG anti-phosphatidylserine antibodies (aPS) are not included as well [12,13].
With respect to the clinical manifestations, the new 2023 ACR/EULAR APS classification criteria allow for the stratification of risk for macrovascular events through the assessment of traditional thrombosis risk factors with weighted assessment. The definitions of high-risk venous thromboembolism and cardiovascular disease are presented in the article. These criteria also define microvascular domain items considered mechanistically distinct from moderate-to-large vessel disease. Indeed, features, such as APS Nephropathy, cardiac valve disease, livedo racemose, and thrombocytopenia, have been added to better capture and quantify the diverse manifestations of APS. These new 2023 ACR/EULAR APS classification criteria have a specificity of 99% compared to the 86–91% specificity of the 2006 Revised Sapporo criteria [12]. Table 1 summarizes the main differences between 2006 Revised Sapporo criteria and 2023 ACR/EULAR classification criteria.

1.4. Antiphospholipid Antibodies in Hemodialysis Patients

ESKD is rare in APS [14]. On the other hand, aPL-persistent positivity is frequently seen in ESKD. Its prevalence is higher in HD patients when compared to ESKD conservatively treated, to peritoneal dialysis patients and to general population [15]. Indeed, the prevalence of aPL in HD patients varies from 11 to 56% [16,17,18,19,20,21,22,23] and is estimated to range between 40 and 50 cases per 100,000 in the general population [24]. However, aPL positivity is inconsistently associated with AVF complications such as thrombosis and stenosis.
In this review, we will discuss the etiopathogenic role of aPL in AVF complications in HD patients and the available treatment options. We will focus on native AVF immediate complications, maturation failure, and stenosis or thrombosis associated with aPL status. Complications related to AVG or CVC are not discussed in the present article.

2. Methods

A literature review was performed using a PubMed electronic search by using the following words:
For AVF Maturation: arteriovenous fistula AND maturation AND (antiphospholipid antibody OR anticardiolipin antibody OR anti beta 2 glycoprotein I OR lupus anticoagulant OR antiphospholipid syndrome).
For AVF Thrombosis: arteriovenous fistula AND thrombosis AND (antiphospholipid antibody OR anticardiolipin antibody OR anti beta 2 glycoprotein I OR lupus anticoagulant OR antiphospholipid syndrome).
For AVF Stenosis: arteriovenous fistula AND stenosis AND (antiphospholipid antibody OR anticardiolipin antibody OR anti beta 2 glycoprotein I OR lupus anticoagulant OR antiphospholipid syndrome).
A total of 32 articles were found and analyzed. References of the included articles were also checked. Case reports and articles reporting only AVG or CVC were not included in the present paper. Papers in French and in English were included.

3. Interpretation and Limitation of aPL Positivity in HD Patients

The possible impact of aPL on the incidence of AVF complications is the subject of contradictory findings raising the hypothesis that aPL positivity is an epiphenomenon in ESKD. Several hypotheses have been proposed. First, false-positive aPL may be observed during anticoagulation therapy, widely used in HD patients [25]. aPL positivity might also be explained by molecular mimicry as a response to the exposure to microorganisms, such as hepatitis C virus [26,27], exposure to endotoxins related either to ESKD, or to HD. Also, the role of the gut microbiota modification in ESKD has been suggested [28,29]. Hemodialysis membranes have also been associated with higher incidence of aPL (e.g., cuprophane membranes) [30]. These findings are consistent with the higher prevalence and higher titers of aPL seen in HD patients compared to conservatively treated ESKD patients [15,20,31]. The same observation is made in patients with AVG compared to native AVF [20]. Whether higher prevalence of aPL is related to the use of an AVG or if aPL positivity is associated with vessels injury and therefore the need for AVG is unknown. Some authors suggest that aPL positivity in ESKD may simply reflect a response to oxidation (i.e., cross-reactive immunoglobulins against epitopes of oxidized lipids) that worsens as ESKD progresses [15]. Interestingly, a prospective study performed by Jamshid Roozbeh et al. found that HD vintage but also a greater number of dialysis sessions were associated with a higher prevalence of aCL [17].
There are major limitations when comparing studies on aPL positivity in HD patients over the years. Indeed, during the past decades, evolution of dialysis techniques (e.g., high flux dialyzer, online hemodiafiltration, ultrapure dialysate) and improvements in membrane biocompatibility led to better patient outcomes with less inflammation, better clearance of small and middle size molecules, as well as uremic toxins [32]. Despite these changes, the prevalence of aPL positivity in HD patients did not drop [28].
Other limitations are related to the heterogenicity of aPL assays: (a) most of the studies focused on IgG aCL, with or without IgM aCL, (b) aβ2-GPI was proposed as an laboratory diagnosis criterion only since 2006 [11], (c) new assays for LA have been developed and new guidelines have been published [25,33], (d) different cut off are used for aCL and aβ2-GPI and some studies use a cut off below a significant clinical threshold, (e) heterogeneous units are used for aCL and aβ2-GPI, and (f) uneven use of aPL confirmation at 12 weeks. Table 2 summarizes available studies on aPL and AVF outcomes and specifies aPL assays, the cutoff used and whether aPL was confirmed.
Finally, studies on aPL profile stability over time have shown that about 10% of APS patients will experience aPL negativisation. In a prospective study on 259 APS patients, 8.9% of the patients experienced negativisation over a 5 year follow-up period. Negativisation was defined as repeated aPL measurements on at least two consecutive occasions at least 12 weeks apart, with a follow-up of at least 1 year from the time aPL first turned negative. In this study, none of the patients experienced any recurrent thrombotic event during the follow-up period after negativisation. Negativisation was mainly observed in single aPL positive patients [46,47]. Whether anticoagulation should be stopped in these patients is not known. Interestingly, in hemodialysis patients, the same observation was reported in a retrospective study on 208 patients. About 16% of the patients experienced either a negativisation or a seroconversion of aPL. However, the outcomes on vascular access thrombosis of this specific group was not reported. In this study, negativisation was defined as a negative aPL assay after only one positive assay [36]. We recently performed a retrospective study including 103 HD patients and we reported similar findings. Indeed, 20% of our cohort experienced either a negativisation or a seroconversion of aPL. Negativisation was defined as one or multiple negative aPL assays after one positive aPL assay. Interestingly, this subgroup of patients had significantly higher maturation failure rates compared to aPL negative patients. This study was designed to assess AVF thrombosis or stenosis, only during the AVF maturation period (i.e., a 6-week period) [48].

4. Antiphospholipid Mediated AVF Complications

4.1. AVF Maturation

After native AVF surgical creation, the outflow vein goes through a complex vascular remodeling process called the “maturation process”, usually taking place within 4 to 6 weeks. Actually, this time period can continue during three post-operative months [49]. The outflow vein will experience vasodilatation and wall thickening therefore allowing a two-needle puncture [50]. AVF maturation can be assessed clinically or by using ultrasound imaging mainly based on AVF blood flow and outflow vein diameter [51,52]. AVF maturation failure is a frequent complication that affects more than half of the AVF and requires frequent interventions in order to facilitate maturation (i.e., assisted maturation) [50,53]. Intimal hyperplasia is the main stenosis lesion and the leading cause of AVF non maturation [54]. It has been associated with endothelial dysfunction both in vivo and in vitro [55,56,57]. In the multicenter prospective Hemodialysis Maturation Fistula Study, interventions performed for AVF stenosis were the most frequent interventions aiming to facilitate AVF maturation [53].
To our knowledge, no study has investigated the association between APS or aPL positivity and native AVF maturation failure. A cross-sectional study by Sunnesh Reddy Anapalli et al., published in 2022, found a statistically significant association between IgG and IgM and aCL and AVF failure, defined as an AVF that never went to the point of successful cannulation, or failed within the first three months. This study focusing on 50 patients with native AVF failure and 50 controls, IgG aCL and IgM aCL were associated with AVF thrombosis. AVF Maturation was not directly assessed in this study. Also, they did not mention if aCL were persistently positive and their cut off for IgG aCL and IgM aCL were > 10 GPL and > 15 MPL, respectively [45]. One clinical case reported AVF maturation failure in a patient with primary APS [58]. Our retrospective study on 103 HD patients showed a statistically significant association between AVF maturation failure (defined by the absence or a delay of maturation according to KDOQI guidelines) and aPL or APS. This association was independent of stenosis and intimal hyperplasia in a multivariate analysis. Interestingly, we reported that patients with a fluctuation aPL profiles also have a significant higher prevalence of AVF maturation failure [48]. We hypothesized that aPL might cause AVF maturation failure, possibly through endothelial dysfunction leading to an impaired vascular remodeling capability without stenosis [7,59,60]. Moreover, because APS is associated with endothelial dysfunction and intimal hyperplasia in some aPL-related manifestations [7,8,61], AVF maturation failure could be related to stenosis and intimal hyperplasia in the setting of aPL positivity. Also, AVF maturation failure could be related to early thrombosis in the setting of aPL positivity. Figure 1 summarizes the putative pathogenesis of aPL-related AVF maturation failure. Further research is needed to better understand the underlying mechanisms and to develop effective strategies for preventing and treating AVF maturation failure in patients with APS or aPL.

4.2. AVF Thrombosis

ESKD is associated with more thrombotic manifestations compared to the general population [62,63]. This higher risk is not fully explained by risk factors encountered in HD population. A hypercoagulability state is usually related to uremic toxins accumulation and is mediated by platelet dysfunction as well as an increased level of the procoagulant tissue factor both in vitro and in vivo [64]. Modification of the functional properties of human venous endothelial cells (VEC) and arterial endothelial cells (AEC) have been observed. Indeed, a recent study reported that VEC acquire a prothrombotic phenotype in contact with uremic serum whereas AEC acquire an inflammatory phenotype [65]. Furthermore, HD is associated with elevated levels of procoagulant factors such as prothrombin fragments and thrombin–antithrombin complexes [45]. Native AVF thrombosis remains a major cause of morbidity in HD patients, representing the most common cause of vascular access failure [66]. Such thrombotic event can occur early after AVF creation, usually due to an inflow problem (e.g., juxta anastomotic stenosis, technical errors of construction, and anatomic abnormalities) or later due to outflow vein stenosis or intimal hyperplasia [45].
The role of hereditary and acquired thrombophilia in AVF failure and AVF patency has been reported in few studies, and data suggest that most of the AVF thrombosis in the setting of thrombophilia occurs during the first month after AVF creation [40,44,45]. Because of the higher risk of arterial and venous thrombosis in patients with persistent aPL, AVF thrombosis would be expected to occur more predominantly in these patients. Indeed, several studies have described the association between aPL and AVF thrombosis whereas others did not find such association. Table 3 summarizes the available studies on aPL and native AVF thrombosis. A systematic review and meta-analysis confirmed the association between aPL (lupus anticoagulant and IgG aCL) and AVF thrombosis [15]. Non-criteria antibodies that are not included in the 2023 ACR/EULAR classification criteria for APS have been associated with AVF thrombosis such as IgA aβ2GPI [21,22,42]. On the contrary, IgG and IgM aβ2GPI have not been associated with native AVF thrombosis in the literature.
Whether AVF thrombosis in the setting of aPL positivity is favored by stenosis or intimal hyperplasia is not known. Indeed, in the setting of aPL positivity, early thrombosis could be favored by anastomotic intimal hyperplasia [67,68]. Intimal hyperplasia is a well-known non-thrombotic histological lesion of APS, well described in aPL-associated disorders such as aPL-associated nephropathy [61,69]. The latter involves the activation of the mTOR signaling pathway [10]. On the other hand, late AVF stenosis and intimal hyperplasia are caused by tissue remodeling and proliferation which may gradually progress during fistula aging and HD procedure itself (needle injury, change in blood flow, etc.). Indeed, HD duration has been described as a risk factor for AVF thrombosis [37,42].

4.3. Stenosis and Intimal Hyperplasia

One of the most common complications associated with a native AVF is the stenosis of the outflow vein, resulting in thrombosis, the most common cause of late AVF loss [70]. Both stenosis and thrombosis compromise AVF primary patency and usually coincide, but they cannot always be distinguished [22]. Stenosis is commonly reported in up to 60% of functional AVF. This finding is of interest because AVF thrombosis is usually attributed to the presence of venous stenosis or inflow abnormalities (anastomotic stenosis). The implementation of a surveillance program dedicated to the detection of progressive subclinical stenosis is of importance as data suggest that multiple factors are required for AVF failure [50].
A common cause of stenosis is intimal hyperplasia, which is well described in AVF [67,68]. Intimal hyperplasia is a crucial histopathological injury and forms the basis for vascular stenosis. It implies shear stress, endothelial dysfunction, inflammation, proliferation, and migration of vascular smooth muscle cells and extracellular matrix amalgamation and degradation [54]. It can take place either at anastomotic levels in the outflow vein or playing a role in restenosis after angioplasty. The prevalence of the latter complication has dropped since the use of drug coated balloon or stent mostly using paclitaxel for its anti-proliferative effect [54]. Despite the description of intimal hyperplasia in outflow veins before AVF surgical creation, studies failed to find any association between pre-existing intimal hyperplasia and AVF stenosis [53,67].
There are few studies evaluating AVF stenosis in the setting of aPL positivity in HD patients. In a combined retrospective and prospective cohort study of a single outpatient dialysis unit, the presence of IgM aCL was associated with AVF stenosis. In multivariate analysis, the presence of stenosis was significantly associated with the development of AVF thrombosis [71]. To our knowledge, intrastent restenosis or restenosis after drug-eluted balloon have not been studied in aPL positive HD patients. However, few studies have demonstrated that patients with APS are predisposed to high rates of restenosis of the coronary arteries after percutaneous coronary intervention [72]. As previously said, intimal hyperplasia is a well-known non-thrombotic histological lesion associated with aPL positivity involving the activation of the mTOR signaling pathway [10]. Up to now, no studies comparing AVF restenosis and drug-eluted angioplasty (e.g., sirolimus coated balloon angioplasty) in aPL positive HD patients are currently available.

4.4. Mortality

Serrano et al. reported in a 2-year prospective study that IgA aβ2GPI positivity was associated with a higher mortality rate, compared to negative patients [21]. However, other authors found no association with mortality [16].

5. Antiphospholipid Antibody Testing before AVF Creation

Routine thrombophilia screening is not recommended before HD vascular access surgery [22,73]. However, certain risk factors, such as history of prior AVF failure, history of unprovoked venous or arterial thrombosis, especially at a young age, should raise the suspicion of thrombophilia. Because aPL positivity appears as an additional risk indicator for AVF failures, we would recommend performing aPL screening, when possible, as a preoperative test. Indeed, most of the time, first laboratory assessment for thrombophilia occurs after the occurrence of an AVF complication, making the interpretation challenging. Knowing aPL status could also help clinicians to select the optimal perioperative therapy in order not only to promote AVF maturation, but also to guide the surveillance of the vascular access.

6. Treatment Options

Despite the high prevalence of aPL in HD populations, there are no specific treatment guidelines for aPL associated AVF complications. Treatment options should follow HD guidelines for medical or surgical treatments and endovascular interventions promoting AVF maturation and surgical and endovascular interventions for non-maturing AVF and for AVF surveillance with the objective to maintain long-term AVF patency [73].
Because of accelerated atherosclerosis in patients with persistent aPL, cardiovascular risk factors should be considered for the prevention or treatment of AVF complications. In aPL-positive patients without a history of thrombosis, low-dose aspirin should be balanced with bleeding risks for primary prevention of thrombotic manifestation, although its effect is uncertain on AVF maturation [73].
Regardless of other thrombotic manifestations, whether vitamin K antagonists (VKA) should be initiated after AVF thrombosis in the setting of aPL positivity is not known. Major bleeding complications have been associated with the use of VKA in the HD population [74]; VKA also have detrimental effects on AVF remodeling process by promoting intimal hyperplasia and calcification [75]. Despite the superior benefit-risk profile of direct oral anticoagulants versus VKA observed in the HD population, the use of the latter anticoagulant should be avoided because of the increased risk of arterial thrombosis in APS patients [76]. Low-molecular-weight-heparin could be a reasonable option in these patients. Further studies are needed to answer these questions.
Potential future therapeutic strategies should focus on targeting endothelial dysfunction, intimal hyperplasia, or the coagulation system depending on the vascular access complication. Also targeting mTOR pathway might be a therapeutic option in selected patients. However, more studies are needed because the lack of knowledge in the pathophysiology of aPL associated AVF thrombosis, stenosis, or maturation failure.

7. Conclusions

Antiphospholipid antibody positivity is frequent in HD patients, and its prevalence is higher than in the general population or in the conservatively treated ESKD. Persistent positivity of aPL is associated with native AVF thrombosis, and aCL and LA positivity seem to be particularly associated with AVF thrombosis. However, data are lacking regarding AVF maturation and stenosis. Further studies are necessary in order to clarify the association between aPL and stenosis or maturation failure, but also to develop effective strategies for preventing and treating AVF maturation failure in patients with APS or aPL.

Author Contributions

M.T. wrote the manuscript and performed the literature review. A.J., L.J. and M.D.C.F.M. critically revised the manuscript and brought useful additions to the text after critical reading. A.D. and J.N. supervised the writing of the manuscript. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

No new data were created or analyzed in this study. Data sharing is not applicable to this article.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Saran, R.; Robinson, B.; Abbott, K.C.; Bragg-Gresham, J.; Chen, X.; Gipson, D.; Gu, H.; Hirth, R.A.; Hutton, D.; Jin, Y.; et al. US Renal Data System 2019 Annual Data Report: Epidemiology of Kidney Disease in the United States. Am. J. Kidney Dis. 2020, 75 (Suppl. S1), A6–A7. [Google Scholar] [CrossRef] [PubMed]
  2. Casserly, L.F.; Dember, L.M. Thrombosis in end-stage renal disease. Semin. Dial. 2003, 16, 245–256. [Google Scholar] [CrossRef] [PubMed]
  3. Roy-Chaudhury, P.; Kelly, B.S.; Melhem, M.; Zhang, J.; Li, J.; Desai, P.; Munda, R.; Heffelfinger, S.C. Vascular access in hemodialysis: Issues, management, and emerging concepts. Cardiol. Clin. 2005, 23, 249–273. [Google Scholar] [CrossRef] [PubMed]
  4. Lawson, J.H.; Niklason, L.E.; Roy-Chaudhury, P. Challenges and novel therapies for vascular access in haemodialysis. Nat. Rev. Nephrol. 2020, 16, 586–602. [Google Scholar] [CrossRef] [PubMed]
  5. Knight, J.S.; Branch, D.W.; Ortel, T.L. Antiphospholipid syndrome: Advances in diagnosis, pathogenesis, and management. BMJ 2023, 380, e069717. [Google Scholar] [CrossRef] [PubMed]
  6. Knight, J.S.; Kanthi, Y. Mechanisms of immunothrombosis and vasculopathy in antiphospholipid syndrome. Semin. Immunopathol. 2022, 44, 347–362. [Google Scholar] [CrossRef]
  7. Velásquez, M.; Rojas, M.; Abrahams, V.M.; Escudero, C.; Cadavid, Á.P. Mechanisms of Endothelial Dysfunction in Antiphospholipid Syndrome: Association with Clinical Manifestations. Front. Physiol. 2018, 9, 1840. [Google Scholar] [CrossRef]
  8. Cugno, M.; Borghi, M.O.; Lonati, L.M.; Ghiadoni, L.; Gerosa, M.; Grossi, C.; De Angelis, V.; Magnaghi, G.; Tincani, A.; Mari, D.; et al. Patients with antiphospholipid syndrome display endothelial perturbation. J. Autoimmun. 2010, 34, 105–110. [Google Scholar] [CrossRef]
  9. Nochy, D.; Daugas, E.; Droz, D.; Beaufils, H.; Grünfeld, J.P.; Piette, J.C.; Bariety, J.; Hill, G. The intrarenal vascular lesions associated with primary antiphospholipid syndrome. J. Am. Soc. Nephrol. 1999, 10, 507–518. [Google Scholar] [CrossRef]
  10. Canaud, G.; Bienaimé, F.; Tabarin, F.; Bataillon, G.; Seilhean, D.; Noël, L.-H.; Dragon-Durey, M.-A.; Snanoudj, R.; Friedlander, G.; Halbwachs-Mecarelli, L.; et al. Inhibition of the mTORC pathway in the antiphospholipid syndrome. N. Engl. J. Med. 2014, 371, 303–312. [Google Scholar] [CrossRef]
  11. Miyakis, S.; Lockshin, M.D.; Atsumi, T.; Branch, D.W.; Brey, R.L.; Cervera, R.; Derksen, R.H.W.M.; DE Groot, P.G.; Koike, T.; Meroni, P.L.; et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J. Thromb. Haemost. 2006, 4, 295–306. [Google Scholar] [CrossRef] [PubMed]
  12. Barbhaiya, M.; Zuily, S.; Naden, R.; Hendry, A.; Manneville, F.; Amigo, M.-C.; Amoura, Z.; Andrade, D.; Andreoli, L.; Artim-Esen, B.; et al. 2023 ACR/EULAR antiphospholipid syndrome classification criteria. Ann. Rheum. Dis. 2023, 82, 1258–1270. [Google Scholar] [CrossRef] [PubMed]
  13. Liu, X.; Zhu, L.; Liu, H.; Cai, Q.; Yun, Z.; Sun, F.; Jia, Y.; Guo, J.; Li, C. Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added. Front. Immunol. 2022, 13, 972012. [Google Scholar] [CrossRef] [PubMed]
  14. Gracia-Tello, B.; Isenberg, D. Kidney disease in primary anti-phospholipid antibody syndrome. Rheumatology 2017, 56, 1069–1080. [Google Scholar] [CrossRef] [PubMed]
  15. Ames, P.R.J.; Merashli, M.; Bucci, T.; Pastori, D.; Pignatelli, P.; Violi, F.; Bellizzi, V.; Arcaro, A.; Gentile, F. Antiphospholipid antibodies in end-stage renal disease: A systematic review and meta-analysis. Hemodial. Int. 2020, 24, 383–396. [Google Scholar] [CrossRef] [PubMed]
  16. Chew, S.L.; Lins, R.L.; Daelemans, R.; Zachee, P.; De Clerck, L.S.; Vermylen, J. Are antiphospholipid antibodies clinically relevant in dialysis patients? Nephrol. Dial. Transplant. 1992, 7, 1194–1198. [Google Scholar] [CrossRef] [PubMed]
  17. Roozbeh, J.; Serati, A.R.; Malekhoseini, S.A. Arteriovenous fistula thrombosis in patients on regular hemodialysis: A report of 171 patients. Arch. Iran. Med. 2006, 9, 26–32. [Google Scholar]
  18. Ozmen, S.; Danis, R.; Akin, D.; Batun, S. Anticardiolipin antibodies in hemodialysis patients with hepatitis C and their role in fistula failure. Clin. Nephrol. 2009, 72, 193–198. [Google Scholar]
  19. Brunet, P.; Aillaud, M.F.; San Marco, M.; Philip-Joet, C.; Dussol, B.; Bernard, D.; Juhan-Vague, I.; Berland, Y. Antiphospholipids in hemodialysis patients: Relationship between lupus anticoagulant and thrombosis. Kidney Int. 1995, 48, 794–800. [Google Scholar] [CrossRef]
  20. Prakash, R.; Miller, C.C.; Suki, W.N. Anticardiolipin antibody in patients on maintenance hemodialysis and its association with recurrent arteriovenous graft thrombosis. Am. J. Kidney Dis. 1995, 26, 347–352. [Google Scholar] [CrossRef]
  21. Serrano, A.; García, F.; Serrano, M.; Ramírez, E.; Alfaro, F.J.; Lora, D.; de la Cámara, A.G.; Paz-Artal, E.; Praga, M.; Morales, J.M. IgA antibodies against β2 glycoprotein I in hemodialysis patients are an independent risk factor for mortality. Kidney Int. 2012, 81, 1239–1244. [Google Scholar] [CrossRef] [PubMed]
  22. Salmela, B.; Hartman, J.; Peltonen, S.; Albäck, A.; Lassila, R. Thrombophilia and arteriovenous fistula survival in ESRD. Clin. J. Am. Soc. Nephrol. 2013, 8, 962–968. [Google Scholar] [CrossRef] [PubMed]
  23. Ghisdal, L.; Broeders, N.; Wissing, K.M.; Mena, J.M.; Lemy, A.; Wijns, W.; Pradier, O.; Donckier, V.; Racapé, J.; Vereerstraeten, P.; et al. Thrombophilic factors in Stage V chronic kidney disease patients are largely corrected by renal transplantation. Nephrol. Dial. Transplant. 2011, 26, 2700–2705. [Google Scholar] [CrossRef] [PubMed]
  24. Dabit, J.Y.; Valenzuela-Almada, M.O.; Vallejo-Ramos, S.; Duarte-García, A. Epidemiology of Antiphospholipid Syndrome in the General Population. Curr. Rheumatol. Rep. 2022, 23, 85. [Google Scholar] [CrossRef]
  25. Wisløff, F.; Jacobsen, E.M.; Liestøl, S. Laboratory diagnosis of the antiphospholipid syndrome. Thromb. Res. 2002, 108, 263–271. [Google Scholar] [CrossRef]
  26. Blank, M.; Asherson, R.A.; Cervera, R.; Shoenfeld, Y. Antiphospholipid syndrome infectious origin. J. Clin. Immunol. 2004, 24, 12–23. [Google Scholar] [CrossRef]
  27. Chuang, F.R.; Chen, T.C.; Yang, C.C.; Cheng, Y.F.; Hsu, K.T.; Lee, C.H.; Lin, C.L.; Wang, I.K.; Chang, H.W.; Wang, P.H. IgM-anticardiolipin antibody and vascular access thrombosis in chronic hemodialysis patients. Ren. Fail. 2005, 27, 25–30. [Google Scholar] [CrossRef]
  28. Bataille, S.; Burtey, S.; Decourt, A.; Frère, C.; Henneuse, A.; Aillaud, M.-F.; Morange, P.; Bardin, N.; Duval, A.; Sallée, M.; et al. Antiphospholipids antibodies and hemodialysis: A frequent association linked to arteriovenous fistula thrombosis. Nephrol. Ther. 2015, 11, 27–33. [Google Scholar] [CrossRef]
  29. van Mourik, D.J.M.; Salet, D.M.; Middeldorp, S.; Nieuwdorp, M.; van Mens, T.E. The role of the intestinal microbiome in antiphospholipid syndrome. Front. Immunol. 2022, 13, 954764. [Google Scholar] [CrossRef]
  30. García-Martín, F.; De Arriba, G.; Carrascosa, T.; Moldenhauer, F.; Martin-Escobar, E.; Val, J.; Saiz, F. Anticardiolipin antibodies and lupus anticoagulant in end-stage renal disease. Nephrol. Dial. Transplant. 1991, 6, 543–547. [Google Scholar] [CrossRef]
  31. Haviv, Y.S. Association of anticardiolipin antibodies with vascular access occlusion in hemodialysis patients: Cause or effect? Nephron 2000, 86, 447–454. [Google Scholar] [CrossRef] [PubMed]
  32. Canaud, B.; Davenport, A.; Golper, T.A. On-line hemodiafiltration therapy for end-stage kidney disease patients: Promises for the future? What’s next? Semin. Dial. 2022, 35, 459–460. [Google Scholar] [CrossRef] [PubMed]
  33. Brandt, J.T.; Triplett, D.A.; Alving, B.; Scharrer, I. Criteria for the diagnosis of lupus anticoagulants: An update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb. Haemost. 1995, 74, 1185–1190. [Google Scholar] [CrossRef] [PubMed]
  34. George, J.; Aron, A.; Levy, Y.; Gilburd, B.; Ben-David, A.; Renaudineau, Y.; Zonana-Nachach, A.; Youinou, P.; Harats, D.; Shoenfeld, Y. Anti-cardiolipin, anti-endothelial-cell and anti-malondialdehyde-LDL antibodies in uremic patients undergoing hemodialysis: Relationship with vascular access thrombosis and thromboembolic events. Hum. Antibodies 1999, 9, 125–131. [Google Scholar] [CrossRef] [PubMed]
  35. Manns, B.J.; Burgess, E.D.; Parsons, H.G.; Schaefer, J.P.; Hyndman, M.E.; Scott-Douglas, N.W. Hyperhomocysteinemia, anticardiolipin antibody status, and risk for vascular access thrombosis in hemodialysis patients. Kidney Int. 1999, 55, 315–320. [Google Scholar] [CrossRef] [PubMed]
  36. Palomo, I.; Pereira, J.; Alarcón, M.; Vasquez, M.; Pierangeli, S. Vascular access thrombosis is not related to presence of antiphospholipid antibodies in patients on chronic hemodialysis. Nephron 2002, 92, 957–958. [Google Scholar] [CrossRef] [PubMed]
  37. Nampoory, M.R.N.; Das, K.C.; Johny, K.V.; Al-Hilali, N.; Abraham, M.; Easow, S.; Saed, T.; Al-Muzeirei, I.A.; Sugathan, T.N.; Al Mousawi, M. Hypercoagulability, a serious problem in patients with ESRD on maintenance hemodialysis, and its correction after kidney transplantation. Am. J. Kidney Dis. 2003, 42, 797–805. [Google Scholar] [CrossRef]
  38. Chuang, Y.C.; Chen, J.B.; Yang, L.C.; Kuo, C.Y. Significance of platelet activation in vascular access survival of haemodialysis patients. Nephrol. Dial. Transplant. 2003, 18, 947–954. [Google Scholar] [CrossRef]
  39. Molino, D.; De Santo, N.G.; Marotta, R.; Anastasio, P.; Mosavat, M.; De Lucia, D. Plasma levels of plasminogen activator inhibitor type 1, factor VIII, prothrombin activation fragment 1 + 2, anticardiolipin, and antiprothrombin antibodies are risk factors for thrombosis in hemodialysis patients. Semin. Nephrol. 2004, 24, 495–501. [Google Scholar] [CrossRef]
  40. Knoll, G.A.; Wells, P.S.; Young, D.; Perkins, S.L.; Pilkey, R.M.; Clinch, J.J.; Rodger, M.A. Thrombophilia and the risk for hemodialysis vascular access thrombosis. J. Am. Soc. Nephrol. 2005, 16, 1108–1114. [Google Scholar] [CrossRef]
  41. Gültekin, F.; Alagözlü, H.; Candan, F.; Nadir, I.; Bakici, M.Z.; Sezer, H. The relationship between anticardiolipin antibodies and vascular access occlusion in patients on hemodialysis. ASAIO J. 2005, 51, 162–164. [Google Scholar] [CrossRef] [PubMed]
  42. Hadhri, S.; Rejeb, M.B.; Belarbia, A.; Achour, A.; Skouri, H. Hemodialysis duration, human platelet antigen HPA-3 and IgA isotype of anti-β2glycoprotein I antibodies are associated with native arteriovenous fistula failure in Tunisian hemodialysis patients. Thromb. Res. 2013, 131, e202–e209. [Google Scholar] [CrossRef] [PubMed]
  43. Fadel, F.I.; Elshamaa, M.F.; Abdel-Rahman, S.M.; Thabet, E.H.; Kamel, S.; Kandil, D.; Ibrahim, M.H.; El-Ahmady, M. Coagulation, thrombophilia and patency of arteriovenous fistula in children undergoing haemodialysis compared with healthy volunteers: A prospective analysis. Blood Coagul. Fibrinolysis 2016, 27, 190–198. [Google Scholar] [CrossRef] [PubMed]
  44. Grupp, C.; Troche-Polzien, I.; Stock, J.; Bramlage, C.; Müller, G.A.; Koziolek, M. Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up. PLoS ONE 2019, 14, e0222102. [Google Scholar] [CrossRef] [PubMed]
  45. Anapalli, S.R.; N, H.D.; Sarma, P.; Srikanth, L.; V, S.K. Thrombophilic risk factors and ABO blood group profile for arteriovenous access failure in end stage kidney disease patients: A single-center experience. Ren. Fail. 2022, 44, 34–42. [Google Scholar] [CrossRef] [PubMed]
  46. Gkrouzman, E.; Sevim, E.; Finik, J.; Andrade, D.; Pengo, V.; Sciascia, S.; Tektonidou, M.G.; Ugarte, A.; Chighizola, C.B.; Belmont, H.M.; et al. Antiphospholipid Antibody Profile Stability Over Time: Prospective Results from the APS ACTION Clinical Database and Repository. J. Rheumatol. 2021, 48, 541–547. [Google Scholar] [CrossRef] [PubMed]
  47. Radin, M.; Schreiber, K.; Sciascia, S.; Roccatello, D.; Cecchi, I.; Aguirre Zamorano, M.Á.; Cuadrado, M.J. Prevalence of Antiphospholipid Antibodies Negativisation in Patients with Antiphospholipid Syndrome: A Long-Term Follow-Up Multicentre Study. Thromb. Haemost. 2019, 119, 1920–1926. [Google Scholar] [CrossRef]
  48. Taghavi, M.; Demulder, A.; Mesquita, M.D.C.F.; Dernier, Y.; Nortier, J.; Collart, F.; Pozdzik, A. Underestimated Effect of Antiphospholipid Antibodies on Arteriovenous Fistula Maturation in Hemodialysis Patients, 09 May 2022, Preprint (Version 1). Research Square. Available online: https://www.researchsquare.com/article/rs-1606215/v1 (accessed on 9 May 2022).
  49. Zonnebeld, N.; Huberts, W.; van Loon, M.M.; Delhaas, T.; Tordoir, J.H.M. Natural Vascular Remodelling After Arteriovenous Fistula Creation in Dialysis Patients With and Without Previous Ipsilateral Vascular Access. Eur. J. Vasc. Endovasc. Surg. 2020, 59, 277–287. [Google Scholar] [CrossRef]
  50. Gameiro, J.; Ibeas, J. Factors affecting arteriovenous fistula dysfunction: A narrative review. J. Vasc. Access. 2020, 21, 134–147. [Google Scholar] [CrossRef]
  51. Lok, C.E.; Huber, T.S.; Lee, T.; Shenoy, S.; Yevzlin, A.S.; Abreo, K.; Allon, M.; Asif, A.; Astor, B.C.; Glickman, M.H.; et al. KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update. Am. J. Kidney Dis. 2020, 75 (Suppl. S2), S1–S164. [Google Scholar] [CrossRef]
  52. Beathard, G.A.; Lok, C.E.; Glickman, M.H.; Al-Jaishi, A.A.; Bednarski, D.; Cull, D.L.; Lawson, J.H.; Lee, T.C.; Niyyar, V.D.; Syracuse, D.; et al. Definitions and End Points for Interventional Studies for Arteriovenous Dialysis Access. Clin. J. Am. Soc. Nephrol. 2018, 13, 501–512. [Google Scholar] [CrossRef] [PubMed]
  53. Huber, T.S.; Berceli, S.A.; Scali, S.T.; Neal, D.; Anderson, E.M.; Allon, M.; Cheung, A.K.; Dember, L.M.; Himmelfarb, J.; Roy-Chaudhury, P.; et al. Arteriovenous Fistula Maturation, Functional Patency, and Intervention Rates. JAMA Surg. 2021, 156, 1111–1118. [Google Scholar] [CrossRef] [PubMed]
  54. Ma, S.; Duan, S.; Liu, Y.; Wang, H. Intimal Hyperplasia of Arteriovenous Fistula. Ann. Vasc. Surg. 2022, 85, 444–453. [Google Scholar] [CrossRef] [PubMed]
  55. Siddiqui, M.A.; Ashraff, S.; Carline, T. Maturation of arteriovenous fistula: Analysis of key factors. Kidney Res. Clin. Pract. 2017, 36, 318–328. [Google Scholar] [CrossRef] [PubMed]
  56. Somarathna, M.; Hwang, P.T.; Millican, R.C.; Alexander, G.C.; Isayeva-Waldrop, T.; Sherwood, J.A.; Brott, B.C.; Falzon, I.; Northrup, H.; Shiu, Y.-T.; et al. Nitric oxide releasing nanomatrix gel treatment inhibits venous intimal hyperplasia and improves vascular remodeling in a rodent arteriovenous fistula. Biomaterials 2022, 280, 121254. [Google Scholar] [CrossRef] [PubMed]
  57. Singh, M.; Mahapatra, H.S.; Pursnani, L.; Muthukumar, B.; Neeraj Anant, I.; Kumar, A.; Kaur, N.; Singh, A.; Krishnan, C. on prediction of arterio-venous fistula maturation by flow mediated dilatation and AVF blood flow. J. Vasc. Access. 2023, 24, 443–451. [Google Scholar] [CrossRef]
  58. Bolleke, E.; Seferi, S.; Rroji, M.; Idrizi, A.; Barbullushi, M.; Thereska, N. Exhausting multiple hemodialysis access failures. Med. Arch. 2014, 68, 361–363. [Google Scholar] [CrossRef]
  59. Evangelatos, G.; Kravvariti, E.; Konstantonis, G.; Tentolouris, N.; Sfikakis, P.P.; Tektonidou, M.G. Atherosclerosis progression in antiphospholipid syndrome is comparable to diabetes mellitus: A 3 year prospective study. Rheumatology 2022, 61, 3408–3413. [Google Scholar] [CrossRef]
  60. Sorice, M.; Profumo, E.; Capozzi, A.; Recalchi, S.; Riitano, G.; Di Veroli, B.; Saso, L.; Buttari, B. Oxidative Stress as a Regulatory Checkpoint in the Production of Antiphospholipid Autoantibodies: The Protective Role of NRF2 Pathway. Biomolecules 2023, 13, 1221. [Google Scholar] [CrossRef]
  61. Barbhaiya, M.; Taghavi, M.; Zuily, S.; Domingues, V.; Chock, E.Y.; Tektonidou, M.G.; Erkan, D.; Seshan, S.V.; New APS Classification Criteria Steering Committee and APS ACTION Collaborators. Efforts to Better Characterize “Antiphospholipid Antibody Nephropathy” for the 2023 ACR/EULAR Antiphospholipid Syndrome Classification Criteria: Renal Pathology Subcommittee Report. J. Rheumatol. 2023, 50, jrheum.2022-1200. [Google Scholar] [CrossRef]
  62. Wattanakit, K.; Cushman, M.; Stehman-Breen, C.; Heckbert, S.R.; Folsom, A.R. Chronic kidney disease increases risk for venous thromboembolism. J. Am. Soc. Nephrol. 2008, 19, 135–140. [Google Scholar] [CrossRef] [PubMed]
  63. Go, A.S.; Bansal, N.; Chandra, M.; Lathon, P.V.; Fortmann, S.P.; Iribarren, C.; Hsu, C.-Y.; Hlatky, M.A.; ADVANCE Study Investigators. Chronic kidney disease and risk for presenting with acute myocardial infarction versus stable exertional angina in adults with coronary heart disease. J. Am. Coll. Cardiol. 2011, 58, 1600–1607. [Google Scholar] [CrossRef] [PubMed]
  64. Gondouin, B.; Cerini, C.; Dou, L.; Sallée, M.; Duval-Sabatier, A.; Pletinck, A.; Calaf, R.; Lacroix, R.; Jourde-Chiche, N.; Poitevin, S.; et al. Indolic uremic solutes increase tissue factor production in endothelial cells by the aryl hydrocarbon receptor pathway. Kidney Int. 2013, 84, 733–744. [Google Scholar] [CrossRef] [PubMed]
  65. Sosińska-Zawierucha, P.; Bręborowicz, A. Uremic serum induces prothrombotic changes in venous endothelial cells and inflammatory changes in aortic endothelial cells. Ren. Fail. 2021, 43, 401–405. [Google Scholar] [CrossRef] [PubMed]
  66. Montagnana, M.; Meschi, T.; Borghi, L.; Lippi, G. Thrombosis and occlusion of vascular access in hemodialyzed patients. Semin. Thromb. Hemost. 2011, 37, 946–954. [Google Scholar] [CrossRef]
  67. Vazquez-Padron, R.I.; Duque, J.C.; Tabbara, M.; Salman, L.H.; Martinez, L. Intimal Hyperplasia and Arteriovenous Fistula Failure: Looking Beyond Size Differences. Kidney360 2021, 2, 1360–1372. [Google Scholar] [CrossRef]
  68. Hu, H.; Patel, S.; Hanisch, J.J.; Santana, J.M.; Hashimoto, T.; Bai, H.; Kudze, T.; Foster, T.R.; Guo, J.; Yatsula, B.; et al. Future research directions to improve fistula maturation and reduce access failure. Semin. Vasc. Surg. 2016, 29, 153–171. [Google Scholar] [CrossRef]
  69. Martínez-Flores, J.A.; Serrano, M.; Morales, J.M.; Serrano, A. Antiphospholipid Syndrome and Kidney Involvement: New Insights. Antibodies 2016, 5, 17. [Google Scholar] [CrossRef]
  70. Turmel-Rodrigues, L.; Mouton, A.; Birmelé, B.; Billaux, L.; Ammar, N.; Grézard, O.; Hauss, S.; Pengloan, J. Salvage of immature forearm fistulas for haemodialysis by interventional radiology. Nephrol. Dial. Transplant. 2001, 16, 2365–2371. [Google Scholar] [CrossRef]
  71. Adler, S.; Szczech, L.; Qureshi, A.; Bollu, R.; Thomas-John, R. IgM anticardiolipin antibodies are associated with stenosis of vascular access in hemodialysis patients but do not predict thrombosis. Clin. Nephrol. 2001, 56, 428–434. [Google Scholar]
  72. Perl, L.; Netzer, A.; Rechavia, E.; Bental, T.; Assali, A.; Codner, P.; Mager, A.; Battler, A.; Kornowski, R.; Lev, E.I. Long-term outcome of patients with antiphospholipid syndrome who undergo percutaneous coronary intervention. Cardiology 2012, 122, 76–82. [Google Scholar] [CrossRef] [PubMed]
  73. Gallieni, M.; Hollenbeck, M.; Inston, N.; Kumwenda, M.; Powell, S.; Tordoir, J.; Al Shakarchi, J.; Berger, P.; Bolignano, D.; Cassidy, D.; et al. Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults. Nephrol. Dial. Transplant. 2019, 34 (Suppl. S2), ii1–ii42. [Google Scholar] [CrossRef] [PubMed]
  74. Almajdi, A.; Almutairi, S.; Alharbi, M. Safety and efficacy of apixaban versus low-molecular weight heparin or vitamin-K antagonists for venous thromboembolism treatment in patients with severe renal failure: A systematic review and meta-analysis. Thromb. Res. 2023, 229, 77–85. [Google Scholar] [CrossRef] [PubMed]
  75. Zaragatski, E.; Grommes, J.; Schurgers, L.J.; Langer, S.; Kennes, L.; Tamm, M.; Koeppel, T.A.; Kranz, J.; Hackhofer, T.; Arakelyan, K.; et al. Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: Role of vitamin K treatment? Kidney Int. 2016, 89, 601–611. [Google Scholar] [CrossRef]
  76. Porta, S.V.; de Andrade, D.C.O.; Erkan, D.; Gómez-Puerta, J.A.; Jara, L.J.; Alba Moreyra, P.; Pons-Estel, G.J. Controversies in the Management of Antiphospholipid Syndrome. J. Clin. Rheumatol. 2023, 29, e107–e112. [Google Scholar] [CrossRef]
Antibodies 13 00001 g001
Figure 1. Overview of aPL putative pathophysiology in native arteriovenous fistula early and long-term complications. aPL: antiphospholipid antibody, AVF: arteriovenous fistula, HD: hemodialysis, IH intimal hyperplasia, MF maturation failure.
Figure 1. Overview of aPL putative pathophysiology in native arteriovenous fistula early and long-term complications. aPL: antiphospholipid antibody, AVF: arteriovenous fistula, HD: hemodialysis, IH intimal hyperplasia, MF maturation failure.
Antibodies 13 00001 g001
Table 1. Main differences between 2006 revised Sapporo and 2023 ACR/EULAR classification criteria for antiphospholipid syndrome.
Table 1. Main differences between 2006 revised Sapporo and 2023 ACR/EULAR classification criteria for antiphospholipid syndrome.
2006 Revised Sapporo2023 ACR/EULAR
ClassificationAt least 1 clinical criterion AND 1 laboratory criterion3 points from clinical domains AND at least 3 points from laboratory domains
Clinical criteria Entry criteria and scoring: count the highest weighted criterion towards the total score
2 clinical criteria
1. Vascular thrombosis: One or more clinical episodes of arterial, venous, or small vessel thrombosis, in any tissue or organ
2. Pregnancy morbidity		6 clinical domains
1. Macrovascular-Venous Thromboembolism
2. Macrovascular-Arterial Thrombosis
3. Microvascular
4. Obstetric
5. Cardiac Valve
6. Hematology
Considered as non-criteria-manifestations:
- Heart valve diseaseYesNo
- Livedo racemosaYesNo
- ThrombocytopeniaYesNo
- Nephropathy,YesNo
- Neurological manifestationsYesYes
- Pulmonary/Adrenal hemorrhageYesNo
Laboratory criteria
Persistent positivity (at 12 weeks)YesYes
Timeline of aPL positivity and clinical criteriaLess than 5 years of clinical criteriaWithin 3 years of clinical criterion
Thresholds of aCL and/or aβ2GPIaCL: >40 GPL or MPL, or >the
99th percentile
aβ2GPI: >the 99th percentile		aCL or aβ2GPI:
Moderate 40–79 units
High >80 units
Antibodies for laboratory criteria:
- Positive LAYesYes
- IgG aCL or aβ2GPIYesYes
- IgM aCL and/or aβ2GPIYesYes. If isolated: are not sufficient (weight only 1 point)
aCL: anticardiolipin antibody, aβ2GPI: anti-β2 glycoprotein I antibody, LA: lupus anticoagulant.
Table 2. Summary of the literature on aPL-associated AVF thrombosis.
Table 2. Summary of the literature on aPL-associated AVF thrombosis.
YearFirst Author
(Reference)		Study Type, nFollow Up (Months)aPLCut-OffaPL ConfirmationProportion of Native AVFAVF Thrombosis and Outcomes
1991F. Garcia-Martin
[30]		Retrospective
n = 51		NALA, IgG aCL12.5 GPL U/mLNANAIgG aCL: Higher incidence of early (6 to 96 h) thrombosis in IgG aCL (31%) versus control (17%). Concentrations of IgG aCL early AVF thrombosis were significantly greater than in patients without it (18.5 ± 7.4 GPL U/mL versus 7.4 ± 0.8, p < 0.001).
1992S. L. Chew
[16]		Prospective
n = 60		12LA, IgG aCL10 GPLYes100%LA, IgG aCL: no association with AVF thrombosis or death during the 12 months follow up.
1995P. Brunet
[19]		Cross-sectional
n = 97		6LA, IgG aCL20 GPLNA81.40%LA: association with AVF thrombosis, IgG aCL: no association with AVF thrombosis
1995R. Prakash
[20]		Retrospective
n = 17		30IgG aCL23 GPLNA100%No events of AVF thrombosis were encountered during the period of review.
1999J. George
[34]		case–control
n = 81		NAaCL, aβ2GPINANA6.2%aCL, aβ2-GPI: no association with AVF thrombosis
1999B. J. Manns
[35]		Cross-sectional
n = 118		36IgG aCLlow, moderate, and highly positive as follows: 11 to 20 GPL, 21 to 80 GPL, and more than 80 GPLNA75%IgG aCL: not associated with AVF thrombosis
2000Y.S. Haviv
[31]		Retrospective
n = 54		NAIgG and IgM aCL, IgG and IgM aβ2-GPI10 IU/mLNA31.50%IgG and IgM aCL: association with AVF occlusion (thrombosis or IH). IgG and IgM aβ2-GPI: not associated with occlusion
2002I. Palomo
[36]		Retrospective
n = 208		NAaCL, aβ2-GPI and aPS3 SD above the average of the normal controlsNA100%aPL: no association with AVF thrombosis.
2003M.R.N. Nampoory
[37]		Retrospective
n = 82		NALA, IgG and IgM aCL, IgG and IgM aPSIgG aCL: ≥23 GPU, IgM aCL: ≥11 MPU, IgG aPS: ≥17 GPS, IgM aPS: ≥23 MPSNA70.70%LA: association with AVF thrombosis, IgG, IgM aCL and IgG, IgM aPS: no association with AVF thrombosis
2003Y-C. Chuang
[38]		Cross-sectional
n = 48		NAIgG aCL12 GPL-UumlNA52.10%No IgG aCL positivity in this cohort
2004D.Molino
[39]		Retrospective
n = 40		NALA, IgG and IgM aCL, Ig G and IgM aPTNANA100.00%Ig G, IgM aPT, IgG, IgM aCL: significantly associated with AVF thrombosis
2005F-R. Chuang
[27]		Cross-sectional
n = 483		NAIgM aCLIgM aCL: 6 GPL-U/mLNA72.30%IgM aCL: not associated with AVF thrombosis
2005G. A. Knoll
[40]		Case-control
n = 419		NALA, IgG aCL, IgM aCLIgG, IgM aCL: medium titer of 30 GPL or MPL U/mLNo91.40%aCL: not associated with AVF thrombosis
2005F. Gültekin
[41]		Retrospective
n = 103		NAIgG, IgM aCLNANA100%IgG, IgM aCL: not associated with AVF thrombosis
2006J. Roozbeh
[17]		Prospective
n = 171		14IgG aCLNegative: <10 GPL.
Low positive: 10 ≤ aCL < 20 GPL, Medium positive: 20 ≤ aCL < 40 GPL, and highly positive: ≥ 40 GPL units.		NA100%IgG aCL: not associated with AVF thrombosis
2009S. Ozmen
[18]		Cross-sectional
n = 103		NAIgG, IgM aCLNANANANot associated with AVF thrombosis, and AVF survival
2012A. Serrano
[21]		Prospective
n = 124		24IgG, IgM, IgA aCL,
IgG, IgM, IgA aβ2-GPI		20 U/mLYes100%IgA aβ2-GPI: associated with AVF thrombosis, cardiovascular disease and mortality
2013B. Salmela
[22]		Retrospective
n = 219		NALA, IgG aCL, IgG aβ2-GPI15 U/mLNA100%aPL: not associated with AVF failure (thrombosis or stenosis)
2013S. Hadhri
[42]		Case-control
n = 101		NALA,
IgG, IgM, IgA aCL,
IgG, IgM, IgA aβ2-GPI		95th percentile for healthy blood donors (7 MPL/mL, 10 GPL/mL and 10 APL/mL for IgM, IgG and IgA aCL, respectively, and 8 U/mL for IgM, IgG and IgA anti-β2-GPI)NA100%IgA aβ2-GPI: independent risk factors for AVF thrombosis (OR = 3.4; 95% CI, 1.21 to 9.55; p = 0.02)
2014S. Bataille
[28]		Retrospective
n = 192		NALA, IgG and IgM aCL, IgG and IgM aβ2-GPIaCL and aβ2-GPI: 99e percentileNA68%aPL and LA: significantly associated with AVF thrombosis
2016F. I. Fadel
[43]		Prospective
n = 50		48IgG aCLNANA80%IgG aCL: significantly associated with AVF thrombosis.
2019C. Grupp
[44]		Prospective
n = 70		384LA, IgG, IgM, and IgA aCLRespectively 12 GPLU/mL, 6 MPLU/mL, and 10 APL U/mLNo100%LA, IgG, IgA, IgM aCL: significantly associated with AVF thrombosis. Patient survival tended to be shorter in patients aPL than in control group, but without statistical significance
2022S. R. Anapalli
[45]		Cross-sectional
n = 100		NAIgG and IgM aCLRespectively 10 and 15 MPL unitsNA100%IgG and IgM aCL: significantly associated with AVF thrombosis (p value < 0.001)
2020P.R J. Ames
[15]		systematic review and meta-analysis IgG aCL: n = 1554, LA: n = 511NALA, IgG aCLNANANAIgG aCL and LA associated with AVF thrombosis
aCL: anticardiolipin antibodies, aPS: antiphosphatidyl serin antibody, aPT: antiprothrombin antibodies, AVF: arteriovenous fistula, aβ2-GPI: anti- β2 Glycoprotein I antibodies, LA: lupus anticoagulant, NA: not available.
Table 3. Summary of the articles evaluating the association between the criteria and non-criteria aPL and AVF thrombosis. The cross symbol designates the absence of association between aPL and AVF thrombosis, whereas the check symbol designates an association. Question marks represent studies in which association between aPL and AVF thrombosis in non-interpretable because of the absence of thrombosis or the absence of aPL positivity.
Table 3. Summary of the articles evaluating the association between the criteria and non-criteria aPL and AVF thrombosis. The cross symbol designates the absence of association between aPL and AVF thrombosis, whereas the check symbol designates an association. Question marks represent studies in which association between aPL and AVF thrombosis in non-interpretable because of the absence of thrombosis or the absence of aPL positivity.
Association with AVF Thrombosis
YearFirst Author (References)Study TypenLAIgG aCLIgM aCLIgG aβ2GPIIgM aβ2GPIOther
1991F. Garcia-Martin [30]retrospective51x✓
1992S. L. Chew [16]prospective60xx
1995P. Brunet [19]cross-sectional97✓x
1995R. Prakash [20]retrospective17 ?
1999J. George [34]case-control81 x x
1999B. J. Manns [35]cross-sectional118 x
2002Y.S. Haviv [31]retrospective54 ✓✓xx
2002I. Palomo [36]retrospective208 x x aPS
2003M. R.N. Nampoory [37]retrospective82✓xx aPS
2003Y-C. Chuang [38]cross-sectional48 ??
2004D. Molino [39]retrospective40x✓✓
2005F-R. Chuang [27]cross-sectional483 x
2005G. A. Knoll [40]case-control419xxx
2005F. Gültekin [41]retrospective103 xx
2006J. Roozbeh [17]prospective171 x
2009S. Ozmen [18]cross-sectional103 xx
2012A. Serrano [21]prospective124 xxxxIgA aβ2GPI
2013B. Salmela [22]retrospective219x xx
2013S. Hadhri [42]case-control101 IgA aβ2GPI
2014S. Bataille [28]retrospective192✓
2016F. I. Fadel [43]Prospective55 ✓
2019C. Grupp [44]prospective70✓✓✓ IgA aCL
2022S. R. Anapalli [45]cross-sectional100 ✓✓
2020P. R. J. Ames [15]meta-analysis1554✓
511 ✓
aCL: anticardiolipin antibody, aPS: antiphosphatidyl serin antibody, AVF: arteriovenous fistula, aβ2GPI: anti-β2 glycoprotein I antibody, LA: lupus anticoagulant.
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MDPI and ACS Style

Taghavi, M.; Jabrane, A.; Jacobs, L.; Mesquita, M.D.C.F.; Demulder, A.; Nortier, J. Antiphospholipid Antibodies Associated with Native Arteriovenous Fistula Complications in Hemodialysis Patients: A Comprehensive Review of the Literature. Antibodies 2024, 13, 1. https://doi.org/10.3390/antib13010001

AMA Style

Taghavi M, Jabrane A, Jacobs L, Mesquita MDCF, Demulder A, Nortier J. Antiphospholipid Antibodies Associated with Native Arteriovenous Fistula Complications in Hemodialysis Patients: A Comprehensive Review of the Literature. Antibodies. 2024; 13(1):1. https://doi.org/10.3390/antib13010001

Chicago/Turabian Style

Taghavi, Maxime, Abla Jabrane, Lucas Jacobs, Maria Do Carmo Filomena Mesquita, Anne Demulder, and Joëlle Nortier. 2024. "Antiphospholipid Antibodies Associated with Native Arteriovenous Fistula Complications in Hemodialysis Patients: A Comprehensive Review of the Literature" Antibodies 13, no. 1: 1. https://doi.org/10.3390/antib13010001

APA Style

Taghavi, M., Jabrane, A., Jacobs, L., Mesquita, M. D. C. F., Demulder, A., & Nortier, J. (2024). Antiphospholipid Antibodies Associated with Native Arteriovenous Fistula Complications in Hemodialysis Patients: A Comprehensive Review of the Literature. Antibodies, 13(1), 1. https://doi.org/10.3390/antib13010001

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