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Drinking Water Arsenic and Adverse Reproductive Outcomes in Men and Women: A Systematic PRISMA Review

1
Department of Clinical Medicine, Aarhus University, 8200 Aarhus N, Denmark
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Department of Obstetrics and Gynecology, Fertility Clinic, Horsens Regional Hospital, 8700 Horsens, Denmark
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Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus C, Denmark
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Department of Public Health, Research Unit for Environment, Work and Health, Aarhus University, 8000 Aarhus C, Denmark
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Geological Survey of Denmark and Greenland (GEUS), 8000 Aarhus C, Denmark
*
Author to whom correspondence should be addressed.
Academic Editor: Domenico Cicchella
Water 2021, 13(14), 1885; https://doi.org/10.3390/w13141885
Received: 24 May 2021 / Revised: 24 June 2021 / Accepted: 25 June 2021 / Published: 7 July 2021
(This article belongs to the Section Water and One Health)
Infertility is a worldwide health issue, but mechanisms of both male and female reproductive toxicity remain to be elucidated. So far, a limited focus has been on potentially harmful environmental factors such as arsenic, which is naturally occurring in groundwater. The objective of this review was to systematically investigate the association between arsenic in drinking water and adverse reproductive outcomes in men and women of fertile age. We conducted a systematic literature search and included case-control studies and cohort studies reporting on decreased semen quality characteristics, increased time to pregnancy, infertility, or spontaneous abortion. In total, 433 articles were screened and ultimately, eight studies were included. Included literature was quality assessed with the Newcastle-Ottawa Scale. Findings were reported in a narrative synthesis. Only one study investigated male fertility. An association between increasing arsenic exposure and decreasing semen quality characteristics was found, as well as an indication of arsenic accumulation in seminal plasma. These findings are, however, at high arsenic levels (>1000 µg/L). No consistent evidence was found to support the hypothesis that arsenic exposure from drinking water is a cause of longer waiting time to pregnancy or spontaneous abortion, being the only endpoints investigated in the included literature. In conclusion; the evidence is sparse and of varying quality, however, it does warrant attention, as it conflicts with existing evidence, mainly from cross-sectional or ecologic studies. View Full-Text
Keywords: arsenic; drinking water; infertility; reproductive outcome; semen quality; spontaneous abortion arsenic; drinking water; infertility; reproductive outcome; semen quality; spontaneous abortion
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MDPI and ACS Style

Barsøe, I.M.; Ebdrup, N.H.; Clausen, H.S.; Lyngsø, J.; Schullehner, J.; Ramlau-Hansen, C.H.; Bay, B.; Knudsen, U.B. Drinking Water Arsenic and Adverse Reproductive Outcomes in Men and Women: A Systematic PRISMA Review. Water 2021, 13, 1885. https://doi.org/10.3390/w13141885

AMA Style

Barsøe IM, Ebdrup NH, Clausen HS, Lyngsø J, Schullehner J, Ramlau-Hansen CH, Bay B, Knudsen UB. Drinking Water Arsenic and Adverse Reproductive Outcomes in Men and Women: A Systematic PRISMA Review. Water. 2021; 13(14):1885. https://doi.org/10.3390/w13141885

Chicago/Turabian Style

Barsøe, Ida M., Ninna H. Ebdrup, Hannah S. Clausen, Julie Lyngsø, Jörg Schullehner, Cecilia H. Ramlau-Hansen, Bjørn Bay, and Ulla B. Knudsen 2021. "Drinking Water Arsenic and Adverse Reproductive Outcomes in Men and Women: A Systematic PRISMA Review" Water 13, no. 14: 1885. https://doi.org/10.3390/w13141885

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