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Review

Blueprints for Biosensors: Design, Limitations, and Applications

1
Department of Molecular Sciences, Macquarie University, Sydney, NSW 2109, Australia
2
CSIRO Synthetic Biology Future Science Platform, Canberra, ACT 2601, Australia
*
Author to whom correspondence should be addressed.
Genes 2018, 9(8), 375; https://doi.org/10.3390/genes9080375
Received: 30 May 2018 / Revised: 23 July 2018 / Accepted: 23 July 2018 / Published: 26 July 2018
(This article belongs to the Special Issue Emerging Applications in Synthetic Biology)
Biosensors are enabling major advances in the field of analytics that are both facilitating and being facilitated by advances in synthetic biology. The ability of biosensors to rapidly and specifically detect a wide range of molecules makes them highly relevant to a range of industrial, medical, ecological, and scientific applications. Approaches to biosensor design are as diverse as their applications, with major biosensor classes including nucleic acids, proteins, and transcription factors. Each of these biosensor types has advantages and limitations based on the intended application, and the parameters that are required for optimal performance. Specifically, the choice of biosensor design must consider factors such as the ligand specificity, sensitivity, dynamic range, functional range, mode of output, time of activation, ease of use, and ease of engineering. This review discusses the rationale for designing the major classes of biosensor in the context of their limitations and assesses their suitability to different areas of biotechnological application. View Full-Text
Keywords: biosensors; synthetic biology; analytics; molecular diagnostics; protein switches; aptamers; high-throughput screening; metabolic engineering biosensors; synthetic biology; analytics; molecular diagnostics; protein switches; aptamers; high-throughput screening; metabolic engineering
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MDPI and ACS Style

Carpenter, A.C.; Paulsen, I.T.; Williams, T.C. Blueprints for Biosensors: Design, Limitations, and Applications. Genes 2018, 9, 375. https://doi.org/10.3390/genes9080375

AMA Style

Carpenter AC, Paulsen IT, Williams TC. Blueprints for Biosensors: Design, Limitations, and Applications. Genes. 2018; 9(8):375. https://doi.org/10.3390/genes9080375

Chicago/Turabian Style

Carpenter, Alexander C., Ian T. Paulsen, and Thomas C. Williams 2018. "Blueprints for Biosensors: Design, Limitations, and Applications" Genes 9, no. 8: 375. https://doi.org/10.3390/genes9080375

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