Next Article in Journal
Reorganization of the Y Chromosomes Enhances Divergence in Israeli Mole Rats Nannospalax ehrenbergi (Spalacidae, Rodentia): Comparative Analysis of Meiotic and Mitotic Chromosomes
Next Article in Special Issue
APC and MUTYH Analysis in FAP Patients: A Novel Mutation in APC Gene and Genotype-Phenotype Correlation
Previous Article in Journal
Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers
Previous Article in Special Issue
The Changing Landscape in the Genetic Etiology of Human Tooth Agenesis
Open AccessArticle

Genetic Association with Subgingival Bacterial Colonization in Chronic Periodontitis

Conservative Dentistry Department, School of Dentistry University of Chile, Santiago 8380544, Chile
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, São Paulo, Brazil
Department of Biological and Allied Health Sciences, Sacred Heart University, Bauru 17011-160, São Paulo, Brazil
Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos 07115-280, São Paulo, Brazil
Author to whom correspondence should be addressed.
Genes 2018, 9(6), 271;
Received: 26 February 2018 / Revised: 11 May 2018 / Accepted: 14 May 2018 / Published: 23 May 2018
(This article belongs to the Special Issue DNA Variations in Evolution and Human Diseases)
Chronic periodontitis is the most prevalent form of inflammatory destructive bone disease and has been affecting humans since antiquity. Evidence suggest that genetic factors can highly influence periodontitis risk, modulating disease elements such as the susceptibility to microbial colonization and the nature of subsequent host-microbe interaction. Several single-nucleotide polymorphisms (SNPs) have been associated with the occurrence of periodontitis, but the full range of genetic influence in periodontitis outcomes remains to be determined. In this context, this study comprises an analysis of possible correlation between periodontitis-related genetic variants with changes in the subgingival microbiological pattern performed in a Brazilian population (n = 167, comprising 76 chronic periodontitis patients and 91 healthy subjects). For the genetic characterization, 19 candidate SNPs were selected based on the top hits of previous large genome wide association studies (GWAS), while the subgingival microbiota was characterized for the presence and relative quantity of 40 bacterial species by DNA-DNA checkerboard. The case/control association test did not demonstrate a significant effect of the target SNPs with the disease phenotype. The polymorphism rs2521634 proved significantly associated with Tannerella. forsythia, Actinomyces gerencseriae, Fusobacterium periodonticum, and Prevotella nigrescens; rs10010758 and rs6667202 were associated with increased counts of Porphyromonas gingivalis; and rs10043775 proved significantly associated with decreased counts of Prevotella intermedia. In conclusion, we present strong evidence supporting a direct connection between the host’s genetic profile, specifically rs2521634, rs10010758, rs6667202, and rs10043775 polymorphisms, and the occurrence of chronic periodontitis-associated bacteria. View Full-Text
Keywords: chronic periodontitis; polymorphism; dysbiosis; biofilm chronic periodontitis; polymorphism; dysbiosis; biofilm
Show Figures

Figure 1

MDPI and ACS Style

Cavalla, F.; Biguetti, C.C.; Lima Melchiades, J.; Tabanez, A.P.; De Campos Soriani Azevedo, M.; Favaro Trombone, A.P.; Faveri, M.; Feres, M.; Pompermaier Garlet, G. Genetic Association with Subgingival Bacterial Colonization in Chronic Periodontitis. Genes 2018, 9, 271.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Search more from Scilit
Back to TopTop