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Genes 2018, 9(6), 271; https://doi.org/10.3390/genes9060271

Genetic Association with Subgingival Bacterial Colonization in Chronic Periodontitis

1
Conservative Dentistry Department, School of Dentistry University of Chile, Santiago 8380544, Chile
2
Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru 17012-901, São Paulo, Brazil
3
Department of Biological and Allied Health Sciences, Sacred Heart University, Bauru 17011-160, São Paulo, Brazil
4
Dental Research Division, Department of Periodontology, Guarulhos University, Guarulhos 07115-280, São Paulo, Brazil
*
Author to whom correspondence should be addressed.
Received: 26 February 2018 / Revised: 11 May 2018 / Accepted: 14 May 2018 / Published: 23 May 2018
(This article belongs to the Special Issue DNA Variations in Evolution and Human Diseases)
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Abstract

Chronic periodontitis is the most prevalent form of inflammatory destructive bone disease and has been affecting humans since antiquity. Evidence suggest that genetic factors can highly influence periodontitis risk, modulating disease elements such as the susceptibility to microbial colonization and the nature of subsequent host-microbe interaction. Several single-nucleotide polymorphisms (SNPs) have been associated with the occurrence of periodontitis, but the full range of genetic influence in periodontitis outcomes remains to be determined. In this context, this study comprises an analysis of possible correlation between periodontitis-related genetic variants with changes in the subgingival microbiological pattern performed in a Brazilian population (n = 167, comprising 76 chronic periodontitis patients and 91 healthy subjects). For the genetic characterization, 19 candidate SNPs were selected based on the top hits of previous large genome wide association studies (GWAS), while the subgingival microbiota was characterized for the presence and relative quantity of 40 bacterial species by DNA-DNA checkerboard. The case/control association test did not demonstrate a significant effect of the target SNPs with the disease phenotype. The polymorphism rs2521634 proved significantly associated with Tannerella. forsythia, Actinomyces gerencseriae, Fusobacterium periodonticum, and Prevotella nigrescens; rs10010758 and rs6667202 were associated with increased counts of Porphyromonas gingivalis; and rs10043775 proved significantly associated with decreased counts of Prevotella intermedia. In conclusion, we present strong evidence supporting a direct connection between the host’s genetic profile, specifically rs2521634, rs10010758, rs6667202, and rs10043775 polymorphisms, and the occurrence of chronic periodontitis-associated bacteria. View Full-Text
Keywords: chronic periodontitis; polymorphism; dysbiosis; biofilm chronic periodontitis; polymorphism; dysbiosis; biofilm
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Cavalla, F.; Biguetti, C.C.; Lima Melchiades, J.; Tabanez, A.P.; de Campos Soriani Azevedo, M.; Favaro Trombone, A.P.; Faveri, M.; Feres, M.; Pompermaier Garlet, G. Genetic Association with Subgingival Bacterial Colonization in Chronic Periodontitis. Genes 2018, 9, 271.

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