Chromosome Synapsis and Recombination in Male-Sterile and Female-Fertile Interspecies Hybrids of the Dwarf Hamsters (Phodopus, Cricetidae)

Bikchurina, Tatiana I.; Tishakova, Katerina V.; Kizilova, Elena A.; Romanenko, Svetlana A.; Serdyukova, Natalya A.; Torgasheva, Anna A.; Borodin, Pavel M.

doi:10.3390/genes9050227

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Chromosome Synapsis and Recombination in Male-Sterile and Female-Fertile Interspecies Hybrids of the Dwarf Hamsters (Phodopus, Cricetidae)

Tatiana I. Bikchurina

^1,2,

Katerina V. Tishakova

^1,2,

Elena A. Kizilova

^1,2,

Svetlana A. Romanenko

^2,3

Natalya A. Serdyukova

³,

Anna A. Torgasheva

^1,2 and

Pavel M. Borodin

^1,2,*

Institute of Cytology and Genetics, Russian Academy of Sciences, Siberian Department, Novosibirsk 630090, Russia

Novosibirsk State University, Novosibirsk 630090, Russia

Institute of Molecular and Cellular Biology, Russian Academy of Sciences, Siberian Department, Novosibirsk 630090, Russia

Author to whom correspondence should be addressed.

Genes 2018, 9(5), 227; https://doi.org/10.3390/genes9050227

Received: 27 February 2018 / Revised: 9 April 2018 / Accepted: 18 April 2018 / Published: 25 April 2018

(This article belongs to the Special Issue Evolutionary Genetics of Reproductive Isolation)

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Abstract

Hybrid sterility is an important step in the speciation process. Hybrids between dwarf hamsters Phodopus sungorus and P. campbelli provide a good model for studies in cytological and genetic mechanisms of hybrid sterility. Previous studies in hybrids detected multiple abnormalities of spermatogenesis and a high frequency of dissociation between the X and Y chromosomes at the meiotic prophase. In this study, we found that the autosomes of the hybrid males and females underwent paring and recombination as normally as their parental forms did. The male hybrids showed a significantly higher frequency of asynapsis and recombination failure between the heterochromatic arms of the X and Y chromosomes than the males of the parental species. Female hybrids as well as the females of the parental species demonstrated a high incidence of centromere misalignment at the XX bivalent and partial asynapsis of the ends of its heterochromatic arms. In all three karyotypes, recombination was completely suppressed in the heterochromatic arm of the X chromosome, where the pseudoautosomal region is located. We propose that this recombination pattern speeds up divergence of the X- and Y-linked pseudoautosomal regions between the parental species and results in their incompatibility in the male hybrids. View Full-Text

Keywords: hybrid sterility; sex chromosomes; pseudoautosomal region; synaptonemal complex; MLH1; SYCP3; γH2A.X

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Bikchurina, T.I.; Tishakova, K.V.; Kizilova, E.A.; Romanenko, S.A.; Serdyukova, N.A.; Torgasheva, A.A.; Borodin, P.M. Chromosome Synapsis and Recombination in Male-Sterile and Female-Fertile Interspecies Hybrids of the Dwarf Hamsters (Phodopus, Cricetidae). Genes 2018, 9, 227. https://doi.org/10.3390/genes9050227

AMA Style

Bikchurina TI, Tishakova KV, Kizilova EA, Romanenko SA, Serdyukova NA, Torgasheva AA, Borodin PM. Chromosome Synapsis and Recombination in Male-Sterile and Female-Fertile Interspecies Hybrids of the Dwarf Hamsters (Phodopus, Cricetidae). Genes. 2018; 9(5):227. https://doi.org/10.3390/genes9050227

Chicago/Turabian Style

Bikchurina, Tatiana I., Katerina V. Tishakova, Elena A. Kizilova, Svetlana A. Romanenko, Natalya A. Serdyukova, Anna A. Torgasheva, and Pavel M. Borodin. 2018. "Chromosome Synapsis and Recombination in Male-Sterile and Female-Fertile Interspecies Hybrids of the Dwarf Hamsters (Phodopus, Cricetidae)" Genes 9, no. 5: 227. https://doi.org/10.3390/genes9050227

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Chromosome Synapsis and Recombination in Male-Sterile and Female-Fertile Interspecies Hybrids of the Dwarf Hamsters (Phodopus, Cricetidae)

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