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Genes 2018, 9(2), 103;

Microfluidic Devices for Drug Delivery Systems and Drug Screening

Department of Biochemistry, Faculty of Science, King Abdulaziz University (KAU), Jeddah 21589, Saudi Arabia
Department of Pharmaceutical Sciences, Ophthalmology, and Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA
Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University (KAU), Jeddah 21589, Saudi Arabia
Mathematics and Natural Sciences Department, The American University of Iraq, Sulaimani, Sulaymaniyah 46001, Iraq
Materials Genome Institute, Shanghai University, Shanghai 200444, China
Faculty of Medicine, Ludwig Maximilian University of Munich (LMU), 80539 Munich, Germany
Faculty of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany
Authors to whom correspondence should be addressed.
Received: 23 December 2017 / Revised: 10 February 2018 / Accepted: 12 February 2018 / Published: 16 February 2018
(This article belongs to the Special Issue From the Lab-on-a-Chip to the Organ-on-a-Chip)
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Microfluidic devices present unique advantages for the development of efficient drug carrier particles, cell-free protein synthesis systems, and rapid techniques for direct drug screening. Compared to bulk methods, by efficiently controlling the geometries of the fabricated chip and the flow rates of multiphase fluids, microfluidic technology enables the generation of highly stable, uniform, monodispersed particles with higher encapsulation efficiency. Since the existing preclinical models are inefficient drug screens for predicting clinical outcomes, microfluidic platforms might offer a more rapid and cost-effective alternative. Compared to 2D cell culture systems and in vivo animal models, microfluidic 3D platforms mimic the in vivo cell systems in a simple, inexpensive manner, which allows high throughput and multiplexed drug screening at the cell, organ, and whole-body levels. In this review, the generation of appropriate drug or gene carriers including different particle types using different configurations of microfluidic devices is highlighted. Additionally, this paper discusses the emergence of fabricated microfluidic cell-free protein synthesis systems for potential use at point of care as well as cell-, organ-, and human-on-a-chip models as smart, sensitive, and reproducible platforms, allowing the investigation of the effects of drugs under conditions imitating the biological system. View Full-Text
Keywords: drug and gene delivery systems; in vitro drug screening; cell-on-a-chip; organ-on-a-chip; human-on-a-chip drug and gene delivery systems; in vitro drug screening; cell-on-a-chip; organ-on-a-chip; human-on-a-chip

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Damiati, S.; Kompella, U.B.; Damiati, S.A.; Kodzius, R. Microfluidic Devices for Drug Delivery Systems and Drug Screening. Genes 2018, 9, 103.

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