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Genes 2018, 9(1), 39;

Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly

Department of Specialty, Diagnostic and Experimental Medicine (DIMES), Via San Giacomo 12, 40126 Bologna, Italy
CIG, Interdepartmental Center ‘L. Galvani’, Alma Mater Studiorum, Via G. Petroni 26, 40126 Bologna, Italy
IRCCS Institute of Neurological Sciences, Via Altura 1-8, 40139 Bologna, Italy
Karolinska Institute, Clinical Chemistry, Department of Laboratory Medicine (LABMED), H5, Huddinge University Hospital, 14186 Stockholm, Sweden
CNR Institute of Molecular Genetics, Unit of Bologna, 40136 Bologna, Italy
Applied Biomedical Research Center (CRBA), S. Orsola-Malpighi Polyclinic, 40138 Bologna, Italy
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 22 December 2017 / Accepted: 10 January 2018 / Published: 16 January 2018
(This article belongs to the Special Issue The Epigenetics of Aging and Longevity)
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Aging is a complex multi-layered phenomenon. The study of aging in humans is based on the use of biological material from hard-to-gather tissues and highly specific cohorts. The introduction of cell reprogramming techniques posed promising features for medical practice and basic research. Recently, a growing number of studies have been describing the generation of induced pluripotent stem cells (iPSCs) from old or centenarian biologic material. Nonetheless, Reprogramming techniques determine a profound remodelling on cell epigenetic architecture whose extent is still largely debated. Given that cell epigenetic profile changes with age, the study of cell-fate manipulation approaches on cells deriving from old donors or centenarians may provide new insights not only on regenerative features and physiology of these cells, but also on reprogramming-associated and age-related epigenetic derangement. View Full-Text
Keywords: aging; cell reprogramming; induced Pluripotent Stem Cells; DNA methylation aging; cell reprogramming; induced Pluripotent Stem Cells; DNA methylation

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Ravaioli, F.; Bacalini, M.G.; Franceschi, C.; Garagnani, P. Age-Related Epigenetic Derangement upon Reprogramming and Differentiation of Cells from the Elderly. Genes 2018, 9, 39.

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