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Role of MYC in B Cell Lymphomagenesis
 
 
Review

The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects

1
Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
2
Cytogenetics Laboratory, Laboratory Corporation of America, Research Triangle Park, NC 27709, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Genes 2017, 8(4), 116; https://doi.org/10.3390/genes8040116
Received: 13 January 2017 / Revised: 27 March 2017 / Accepted: 27 March 2017 / Published: 5 April 2017
(This article belongs to the Special Issue MYC Networks)
c-MYC is one of the most essential transcriptional factors, regulating a diverse array of cellular functions, including proliferation, growth, and apoptosis. Dysregulation of c-MYC is essential in the pathogenesis of a number of B-cell lymphomas, but is rarely reported in T-cell lymphomas. c-MYC dysregulation induces lymphomagenesis by loss of the tight control of c-MYC expression, leading to overexpression of intact c-MYC protein, in contrast to the somatic mutations or fusion proteins seen in many other oncogenes. Dysregulation of c-MYC in B-cell lymphomas occurs either as a primary event in Burkitt lymphoma, or secondarily in aggressive lymphomas such as diffuse large B-cell lymphoma, plasmablastic lymphoma, mantle cell lymphoma, or double-hit lymphoma. Secondary c-MYC changes include gene translocation and gene amplification, occurring against a background of complex karyotype, and most often confer aggressive clinical behavior, as evidenced in the double-hit lymphomas. In low-grade B-cell lymphomas, acquisition of c-MYC rearrangement usually results in transformation into highly aggressive lymphomas, with some exceptions. In this review, we discuss the role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c-MYC dysregulation, and their effect on prognosis and diagnosis in specific types of B-cell lymphoma. View Full-Text
Keywords: c-MYC; lymphoma; diffuse large B-cell lymphoma; plasmablastic lymphoma; mantle cell lymphoma; double-hit lymphoma; complex karyotype c-MYC; lymphoma; diffuse large B-cell lymphoma; plasmablastic lymphoma; mantle cell lymphoma; double-hit lymphoma; complex karyotype
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MDPI and ACS Style

Nguyen, L.; Papenhausen, P.; Shao, H. The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects. Genes 2017, 8, 116. https://doi.org/10.3390/genes8040116

AMA Style

Nguyen L, Papenhausen P, Shao H. The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects. Genes. 2017; 8(4):116. https://doi.org/10.3390/genes8040116

Chicago/Turabian Style

Nguyen, Lynh, Peter Papenhausen, and Haipeng Shao. 2017. "The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects" Genes 8, no. 4: 116. https://doi.org/10.3390/genes8040116

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