Role of MYC in B Cell Lymphomagenesis
AbstractB cell lymphomas mainly arise from different developmental stages of B cells in germinal centers of secondary lymphoid tissue. There are a number of signaling pathways that affect the initiation and development of B cell lymphomagenesis. The functions of several key proteins that represent branching points of signaling networks are changed because of their aberrant expression, degradation, and/or accumulation, and those events determine the fate of the affected B cells. One of the most influential transcription factors, commonly associated with unfavorable prognosis for patients with B cell lymphoma, is nuclear phosphoprotein MYC. During B cell lymphomagenesis, oncogenic MYC variant is deregulated through various mechanisms, such as gene translocation, gene amplification, and epigenetic deregulation of its expression. Owing to alterations of downstream signaling cascades, MYC-overexpressing neoplastic B cells proliferate rapidly, avoid apoptosis, and become unresponsive to most conventional treatments. This review will summarize the roles of MYC in B cell development and oncogenesis, as well as its significance for current B cell lymphoma classification. We compared communication networks within transformed B cells in different lymphomas affected by overexpressed MYC and conducted a meta-analysis concerning the association of MYC with tumor prognosis in different patient populations. View Full-Text
- Supplementary File 1:
DOCX-Document (DOCX, 58 KB)
Share & Cite This Article
Korać, P.; Dotlić, S.; Matulić, M.; Zajc Petranović, M.; Dominis, M. Role of MYC in B Cell Lymphomagenesis. Genes 2017, 8, 115.
Korać P, Dotlić S, Matulić M, Zajc Petranović M, Dominis M. Role of MYC in B Cell Lymphomagenesis. Genes. 2017; 8(4):115.Chicago/Turabian Style
Korać, Petra; Dotlić, Snježana; Matulić, Maja; Zajc Petranović, Matea; Dominis, Mara. 2017. "Role of MYC in B Cell Lymphomagenesis." Genes 8, no. 4: 115.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.