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Role of MYC in B Cell Lymphomagenesis

Department of Biology, Division of Molecular Biology, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb, Croatia
Department of Pathology and Cytology, University Hospital Center Zagreb, 10000 Zagreb, Croatia
Institute for Anthropological Research, Gajeva 32, 10000 Zagreb, Croatia
Medical School Zagreb, University of Zagreb, 10000 Zagreb, Croatia
Author to whom correspondence should be addressed.
Academic Editor: Daitoku Sakamuro
Genes 2017, 8(4), 115;
Received: 30 January 2017 / Revised: 20 March 2017 / Accepted: 28 March 2017 / Published: 4 April 2017
(This article belongs to the Special Issue MYC Networks)
B cell lymphomas mainly arise from different developmental stages of B cells in germinal centers of secondary lymphoid tissue. There are a number of signaling pathways that affect the initiation and development of B cell lymphomagenesis. The functions of several key proteins that represent branching points of signaling networks are changed because of their aberrant expression, degradation, and/or accumulation, and those events determine the fate of the affected B cells. One of the most influential transcription factors, commonly associated with unfavorable prognosis for patients with B cell lymphoma, is nuclear phosphoprotein MYC. During B cell lymphomagenesis, oncogenic MYC variant is deregulated through various mechanisms, such as gene translocation, gene amplification, and epigenetic deregulation of its expression. Owing to alterations of downstream signaling cascades, MYC-overexpressing neoplastic B cells proliferate rapidly, avoid apoptosis, and become unresponsive to most conventional treatments. This review will summarize the roles of MYC in B cell development and oncogenesis, as well as its significance for current B cell lymphoma classification. We compared communication networks within transformed B cells in different lymphomas affected by overexpressed MYC and conducted a meta-analysis concerning the association of MYC with tumor prognosis in different patient populations. View Full-Text
Keywords: MYC; B cell; lymphoma; signaling pathways; prognostic factor; meta-analysis MYC; B cell; lymphoma; signaling pathways; prognostic factor; meta-analysis
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Korać, P.; Dotlić, S.; Matulić, M.; Zajc Petranović, M.; Dominis, M. Role of MYC in B Cell Lymphomagenesis. Genes 2017, 8, 115.

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