Next Article in Journal
Hierarchical Control of Nitrite Respiration by Transcription Factors Encoded within Mobile Gene Clusters of Thermus thermophilus
Next Article in Special Issue
Current Research on Non-Coding Ribonucleic Acid (RNA)
Previous Article in Journal
Transcriptional and Hormonal Regulation of Weeping Trait in Salix matsudana
Previous Article in Special Issue
Non-Coding RNAs in Pediatric Airway Diseases
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessCommunication
Genes 2017, 8(12), 358;

Phylogenetic Analysis of the SNORD116 Locus

Translational Biology, Medicine and Health Graduate Program, Virginia Tech, Blacksburg, VA 24061, USA
Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24061, USA
Author to whom correspondence should be addressed.
Received: 31 October 2017 / Revised: 25 November 2017 / Accepted: 26 November 2017 / Published: 30 November 2017
(This article belongs to the Special Issue Non-coding RNAs)
Full-Text   |   PDF [2171 KB, uploaded 4 December 2017]   |  


The SNORD116 small nucleolar RNA locus ([email protected]) is contained within the long noncoding RNA host gene SNHG14 on human chromosome 15q11-q13. The SNORD116 locus is a cluster of 28 or more small nucleolar (sno) RNAs; C/D box (SNORDs). Individual RNAs within the cluster are tandem, highly similar sequences, referred to as SNORD116-1, SNORD116-2, etc., with the entire set referred to as SNORD116@. There are also related SNORD116 loci on other chromosomes, and these additional loci are conserved among primates. Inherited chromosomal 15q11-q13 deletions, encompassing the SNORD116@ locus, are causative for the paternally-inherited/maternally-imprinted genetic condition, Prader–Willi syndrome (PWS). Using in silico tools, along with molecular-based and sequenced-based confirmation, phylogenetic analysis of the SNORD116@ locus was performed. The consensus sequence for the [email protected] snoRNAs from various species was determined both for all the SNORD116 snoRNAs, as well as those grouped using sequence and location according to a human grouping convention. The implications of these findings are put in perspective for studying SNORD116 in patients with inherited Prader–Willi syndrome, as well as model organisms. View Full-Text
Keywords: Prader–Willi Syndrome; snoRNA; phylogenetic analysis; imprinting Prader–Willi Syndrome; snoRNA; phylogenetic analysis; imprinting

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Kocher, M.A.; Good, D.J. Phylogenetic Analysis of the SNORD116 Locus. Genes 2017, 8, 358.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Genes EISSN 2073-4425 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top