Phylogenetic Analysis of the SNORD116 Locus
AbstractThe SNORD116 small nucleolar RNA locus ([email protected]) is contained within the long noncoding RNA host gene SNHG14 on human chromosome 15q11-q13. The SNORD116 locus is a cluster of 28 or more small nucleolar (sno) RNAs; C/D box (SNORDs). Individual RNAs within the cluster are tandem, highly similar sequences, referred to as SNORD116-1, SNORD116-2, etc., with the entire set referred to as SNORD116@. There are also related SNORD116 loci on other chromosomes, and these additional loci are conserved among primates. Inherited chromosomal 15q11-q13 deletions, encompassing the SNORD116@ locus, are causative for the paternally-inherited/maternally-imprinted genetic condition, Prader–Willi syndrome (PWS). Using in silico tools, along with molecular-based and sequenced-based confirmation, phylogenetic analysis of the SNORD116@ locus was performed. The consensus sequence for the [email protected] snoRNAs from various species was determined both for all the SNORD116 snoRNAs, as well as those grouped using sequence and location according to a human grouping convention. The implications of these findings are put in perspective for studying SNORD116 in patients with inherited Prader–Willi syndrome, as well as model organisms. View Full-Text
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Kocher, M.A.; Good, D.J. Phylogenetic Analysis of the SNORD116 Locus. Genes 2017, 8, 358.
Kocher MA, Good DJ. Phylogenetic Analysis of the SNORD116 Locus. Genes. 2017; 8(12):358.Chicago/Turabian Style
Kocher, Matthew A.; Good, Deborah J. 2017. "Phylogenetic Analysis of the SNORD116 Locus." Genes 8, no. 12: 358.
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