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Genes 2017, 8(12), 343;

Epigenetic Basis of Cellular Senescence and Its Implications in Aging

Gene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA 19104, USA
Author to whom correspondence should be addressed.
Received: 30 October 2017 / Revised: 18 November 2017 / Accepted: 21 November 2017 / Published: 24 November 2017
(This article belongs to the Special Issue The Epigenetics of Aging and Longevity)
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Cellular senescence is a tumor suppressive response that has become recognized as a major contributor of tissue aging. Senescent cells undergo a stable proliferative arrest that protects against neoplastic transformation, but acquire a secretory phenotype that has long-term deleterious effects. Studies are still unraveling the effector mechanisms that underlie these senescence responses with the goal to identify therapeutic interventions. Such effector mechanisms have been linked to the dramatic remodeling in the epigenetic and chromatin landscape that accompany cellular senescence. We discuss these senescence-associated epigenetic changes and their impact on the senescence phenotypes, notably the proliferative arrest and senescence associated secretory phenotype (SASP). We also explore possible epigenetic targets to suppress the deleterious effects of senescent cells that contribute towards aging. View Full-Text
Keywords: cellular senescence; aging; epigenetic change; SAHF; SASP cellular senescence; aging; epigenetic change; SAHF; SASP

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Nacarelli, T.; Liu, P.; Zhang, R. Epigenetic Basis of Cellular Senescence and Its Implications in Aging. Genes 2017, 8, 343.

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