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Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips

German Federal Institute for Risk Assessment (BfR), German Centre for the Protection of Laboratory Animals (Bf3R), 10589 Berlin, Germany
iSmart, Materials Genome Institute, Shanghai University (SHU), Shanghai 201800, China
Department of Electrical Engineering, Kaunas University of Technology, 35212 Panevezys, Lithuania
Department of Biochemistry, King Abdulaziz University, Jeddah 80203, Saudi Arabia
Institute for Synthetic Bioarchitecture, Department of Nanobiotechnology, University of Natural Resources and Life Sciences, 1190 Vienna, Austria
Mathematics and Natural Sciences Department, The American University of Iraq, Sulaimani, Sulaymaniyah 46001, Iraq
Authors to whom correspondence should be addressed.
Genes 2017, 8(10), 244;
Received: 2 August 2017 / Revised: 11 September 2017 / Accepted: 20 September 2017 / Published: 27 September 2017
(This article belongs to the Special Issue From the Lab-on-a-Chip to the Organ-on-a-Chip)
Air quality depends on the various gases and particles present in it. Both natural phenomena and human activities affect the cleanliness of air. In the last decade, many countries experienced an unprecedented industrial growth, resulting in changing air quality values, and correspondingly, affecting our life quality. Air quality can be accessed by employing microchips that qualitatively and quantitatively determine the present gases and dust particles. The so-called particular matter 2.5 (PM2.5) values are of high importance, as such small particles can penetrate the human lung barrier and enter the blood system. There are cancer cases related to many air pollutants, and especially to PM2.5, contributing to exploding costs within the healthcare system. We focus on various current and potential future air pollutants, and propose solutions on how to protect our health against such dangerous substances. Recent developments in the Organ-on-Chip (OoC) technology can be used to study air pollution as well. OoC allows determination of pollutant toxicity and speeds up the development of novel pharmaceutical drugs. View Full-Text
Keywords: air pollution; particulate matter (PM); PM2.5; microchip; organ-on-chip (OoC) air pollution; particulate matter (PM); PM2.5; microchip; organ-on-chip (OoC)
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Schulze, F.; Gao, X.; Virzonis, D.; Damiati, S.; Schneider, M.R.; Kodzius, R. Air Quality Effects on Human Health and Approaches for Its Assessment through Microfluidic Chips. Genes 2017, 8, 244.

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