- freely available
Genes Involved in Type 1 Diabetes: An Update
AbstractType 1 Diabetes (T1D) is a chronic multifactorial disease with a strong genetic component, which, through interactions with specific environmental factors, triggers disease onset. T1D typically manifests in early to mid childhood through the autoimmune destruction of pancreatic β cells resulting in a lack of insulin production. Historically, prior to genome-wide association studies (GWAS), six loci in the genome were fully established to be associated with T1D. With the advent of high-throughput single nucleotide polymorphism (SNP) genotyping array technologies, enabling investigators to perform high-density GWAS, many additional T1D susceptibility genes have been discovered. Indeed, recent meta-analyses of multiple datasets from independent investigators have brought the tally of well-validated T1D disease genes to almost 60. In this mini-review, we address recent advances in the genetics of T1D and provide an update on the latest susceptibility loci added to the list of genes involved in the pathogenesis of T1D.
Share & Cite This Article
Bakay, M.; Pandey, R.; Hakonarson, H. Genes Involved in Type 1 Diabetes: An Update. Genes 2013, 4, 499-521.View more citation formats
Bakay M, Pandey R, Hakonarson H. Genes Involved in Type 1 Diabetes: An Update. Genes. 2013; 4(3):499-521.Chicago/Turabian Style
Bakay, Marina; Pandey, Rahul; Hakonarson, Hakon. 2013. "Genes Involved in Type 1 Diabetes: An Update." Genes 4, no. 3: 499-521.