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Genes 2011, 2(1), 21-35;

A Mutation in Mtap2 Is Associated with Arrest of Mammalian Spermatocytes before the First Meiotic Division

The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA
Author to whom correspondence should be addressed.
Received: 25 October 2010 / Revised: 7 December 2010 / Accepted: 15 December 2010 / Published: 10 January 2011
(This article belongs to the Special Issue Genetics of Mammalian Meiosis)
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In spite of evolutionary conservation of meiosis, many of the genes that control mammalian meiosis are still unknown. We report here that the ENU-induced repro4 mutation, identified in a screen to uncover genes that control mouse meiosis, causes failure of spermatocytes to exit meiotic prophase I via the G2/MI transition. Major events of meiotic prophase I occurred normally in affected spermatocytes and known regulators of the meiotic G2/MI transition were present and functional. Deep sequencing of mutant DNA revealed a mutation located in an intron of the Mtap2 gene, encoding microtubule-associated protein 2, and levels of Mtap2 transcript were reduced in mutant testes. This evidence implicates MTAP2 as required directly or indirectly for completion of meiosis and normal spermatogenesis in mammals. View Full-Text
Keywords: meiosis; spermatogenesis; microtubule-associated protein meiosis; spermatogenesis; microtubule-associated protein

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sun, F.; Handel, M.A. A Mutation in Mtap2 Is Associated with Arrest of Mammalian Spermatocytes before the First Meiotic Division. Genes 2011, 2, 21-35.

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