Prenatal Detection of Trisomy 2: Considerations for Genetic Counseling and Testing
Abstract
:1. Introduction
2. Detailed Case Description
3. Laboratory Investigations and Diagnostic Tests
3.1. Invasive and Non-Invasive Prenatal Genetic Investigations
3.2. Pathological and Histological Examination of the Fetus and Placenta after Pregnancy Termination
3.3. Genetic Characterization of the Fetus and Placenta after Pregnancy Termination
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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STR Marker | Primer |
---|---|
D2S272 | F‒ 6-FAM- GGC CAG GTT GAA GAA CAG G R‒ TGG CTT GGG GAT TAT TGT CT |
D2S273 | F‒ ROX- AAA ATT GTG GTG GTG AAT GCT R‒ CAT CGT TTT CAG TTT GAG AGA GA |
D2S278 | F‒ 6-FAM- GAG CCC AGG GTG AAA GAA G R‒ AAT CAC ATG CGT CAA CTC CT |
D2S1248 | F‒ ROX- CCA TCC TCA GTA ACC CCT AC R‒ GCT CCC ATA CTC TCA CTT GC |
D2S272 | D2S273 | D2S278 | D2S1248 | |
---|---|---|---|---|
Mother | 189–223 | 238 | 286–300 | 343–360 |
Fetus | 189–213 | 238–250 | 286–297 | 343–382 |
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Talantova, O.E.; Koltsova, A.S.; Tikhonov, A.V.; Pendina, A.A.; Malysheva, O.V.; Tarasenko, O.A.; Vashukova, E.S.; Shabanova, E.S.; Golubeva, A.V.; Chiryaeva, O.G.; et al. Prenatal Detection of Trisomy 2: Considerations for Genetic Counseling and Testing. Genes 2023, 14, 913. https://doi.org/10.3390/genes14040913
Talantova OE, Koltsova AS, Tikhonov AV, Pendina AA, Malysheva OV, Tarasenko OA, Vashukova ES, Shabanova ES, Golubeva AV, Chiryaeva OG, et al. Prenatal Detection of Trisomy 2: Considerations for Genetic Counseling and Testing. Genes. 2023; 14(4):913. https://doi.org/10.3390/genes14040913
Chicago/Turabian StyleTalantova, Olga E., Alla S. Koltsova, Andrei V. Tikhonov, Anna A. Pendina, Olga V. Malysheva, Olga A. Tarasenko, Elena S. Vashukova, Elena S. Shabanova, Arina V. Golubeva, Olga G. Chiryaeva, and et al. 2023. "Prenatal Detection of Trisomy 2: Considerations for Genetic Counseling and Testing" Genes 14, no. 4: 913. https://doi.org/10.3390/genes14040913
APA StyleTalantova, O. E., Koltsova, A. S., Tikhonov, A. V., Pendina, A. A., Malysheva, O. V., Tarasenko, O. A., Vashukova, E. S., Shabanova, E. S., Golubeva, A. V., Chiryaeva, O. G., Glotov, A. S., Bespalova, O. N., & Efimova, O. A. (2023). Prenatal Detection of Trisomy 2: Considerations for Genetic Counseling and Testing. Genes, 14(4), 913. https://doi.org/10.3390/genes14040913