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10.3390/genes13030403
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Article

Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?

by
Mika Saito
1,
Michał Ginszt
2,
Ekaterina A. Semenova
3,4,
Myosotis Massidda
5,6,
Kinga Huminska-Lisowska
7,
Monika Michałowska-Sawczyn
7,
Hiroki Homma
1,
Paweł Cięszczyk
7,
Takanobu Okamoto
1,
Andrey K. Larin
3,
Edward V. Generozov
3,
Piotr Majcher
2,
Koichi Nakazato
1,
Ildus I. Ahmetov
3,8,9,10 and
Naoki Kikuchi
1,*
1
Graduate School of Health and Sport Science, Nippon Sport Science University, Tokyo 158-8508, Japan
2
Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-059 Lublin, Poland
3
Department of Molecular Biology and Genetics, Federal Research and Clinical Center of Physical-Chemical Medicine of the Federal Medical Biological Agency, 119435 Moscow, Russia
4
Research Institute of Physical Culture and Sport, Volga Region State University of Physical Culture, Sport and Tourism, 420010 Kazan, Russia
5
Department of Life and Environmental Sciences, University of Cagliari, 09124 Cagliari, Italy
6
Faculty of Medicine and Surgery, Graduate School of Exercise and Sports Sciences, University of Cagliari, 09124 Cagliari, Italy
7
Faculty of Physical Education, Gdańsk University of Physical Education and Sport, 80-854 Gdańsk, Poland
8
Department of Physical Education, Plekhanov Russian University of Economics, 115093 Moscow, Russia
9
Laboratory of Molecular Genetics, Kazan State Medical University, 420012 Kazan, Russia
10
Research Institute for Sport and Exercise Sciences, Liverpool John Moore University, Liverpool L3 5UX, UK
*
Author to whom correspondence should be addressed.
Genes 2022, 13(3), 403; https://doi.org/10.3390/genes13030403
Submission received: 2 January 2022 / Revised: 21 February 2022 / Accepted: 21 February 2022 / Published: 23 February 2022
(This article belongs to the Special Issue Genetics and Sports Performance)
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Abstract

The purpose of this study was to compare the frequency of COL1A1 rs1107946 polymorphism between sport climbers and controls from three ethnic groups (Japanese, Polish, and Russian) and investigate the effect of the COL1A1 rs1107946 polymorphism on the age-related decrease in flexibility in the general population. Study I consisted of 1929 healthy people (controls) and 218 climbers, including Japanese, Polish, and Russian participants. The results of the meta-analysis showed that the frequency of the AC genotype was higher in climbers than in the controls (p = 0.03). Study II involved 1093 healthy Japanese individuals (435 men and 658 women). Flexibility was assessed using a sit-and-reach test. There was a tendency towards association between sit-and-reach and the COL1A1 rs1107946 polymorphism (genotype: p = 0.034; dominant: p = 0.435; recessive: p = 0.035; over-dominant: p = 0.026). In addition, there was a higher negative correlation between sit-and-reach and age in the AA + CC genotype than in the AC genotype (AA + CC: r = −0.216, p < 0.001; AC: r = −0.089, p = 0.04; interaction p = 0.037). However, none of these results survived correction for multiple testing. Further studies are warranted to investigate the association between the COL1A1 gene variation and exercise-related phenotypes.
Keywords: genotype; heterozygosity; polymorphism; COL1A1; aging; flexibility; sit-and-reach; sports climbing genotype; heterozygosity; polymorphism; COL1A1; aging; flexibility; sit-and-reach; sports climbing

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MDPI and ACS Style

Saito, M.; Ginszt, M.; Semenova, E.A.; Massidda, M.; Huminska-Lisowska, K.; Michałowska-Sawczyn, M.; Homma, H.; Cięszczyk, P.; Okamoto, T.; Larin, A.K.; et al. Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility? Genes 2022, 13, 403. https://doi.org/10.3390/genes13030403

AMA Style

Saito M, Ginszt M, Semenova EA, Massidda M, Huminska-Lisowska K, Michałowska-Sawczyn M, Homma H, Cięszczyk P, Okamoto T, Larin AK, et al. Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility? Genes. 2022; 13(3):403. https://doi.org/10.3390/genes13030403

Chicago/Turabian Style

Saito, Mika, Michał Ginszt, Ekaterina A. Semenova, Myosotis Massidda, Kinga Huminska-Lisowska, Monika Michałowska-Sawczyn, Hiroki Homma, Paweł Cięszczyk, Takanobu Okamoto, Andrey K. Larin, and et al. 2022. "Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility?" Genes 13, no. 3: 403. https://doi.org/10.3390/genes13030403

APA Style

Saito, M., Ginszt, M., Semenova, E. A., Massidda, M., Huminska-Lisowska, K., Michałowska-Sawczyn, M., Homma, H., Cięszczyk, P., Okamoto, T., Larin, A. K., Generozov, E. V., Majcher, P., Nakazato, K., Ahmetov, I. I., & Kikuchi, N. (2022). Is COL1A1 Gene rs1107946 Polymorphism Associated with Sport Climbing Status and Flexibility? Genes, 13(3), 403. https://doi.org/10.3390/genes13030403

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