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Volume 13
Issue 1
10.3390/genes13010088
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Article

Comprehensive Analysis of Innate Immunophenotyping Based on Immune Score Predicting Immune Alterations and Prognosis in Breast Cancer Patients

by
Weiguang Liu
,
Lingling Xia
,
Zhengmiao Xia
and
Liming Chen
*
Department of Biochemistry, School of Life Sciences, Nanjing Normal University, Nanjing 210023, China
*
Author to whom correspondence should be addressed.
Genes 2022, 13(1), 88; https://doi.org/10.3390/genes13010088
Submission received: 6 December 2021 / Revised: 21 December 2021 / Accepted: 27 December 2021 / Published: 29 December 2021
(This article belongs to the Section Human Genomics and Genetic Diseases)
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Abstract

Breast cancer is the most common cancer, with the highest mortality rate and the most diagnosed cancer type in women worldwide. To identify the effect innate immune checkpoint for breast cancer immunotherapy, the innate immune prognostic biomarkers were selected through the ICI score model and the risk model in breast cancer patients. Moreover, the reliability and accuracy of the ICI score model and the risk model were further examined through the analysis of breast cancer prognosis and immune cell infiltration. The pan cancer analysis further confirmed and selected CXCL9 as the key innate immune checkpoint for breast cancer immunotherapy and identified three small molecular drugs for target CXCL9 through molecular docking analysis. In summary, CXCL9 significantly correlated with the prognostic of breast cancer and immune cell infiltration and could be innate immune checkpoint for breast cancer immunotherapy.
Keywords: breast cancer; innate immune; immune microenvironment; checkpoint immunotherapy; small molecular target drug breast cancer; innate immune; immune microenvironment; checkpoint immunotherapy; small molecular target drug

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MDPI and ACS Style

Liu, W.; Xia, L.; Xia, Z.; Chen, L. Comprehensive Analysis of Innate Immunophenotyping Based on Immune Score Predicting Immune Alterations and Prognosis in Breast Cancer Patients. Genes 2022, 13, 88. https://doi.org/10.3390/genes13010088

AMA Style

Liu W, Xia L, Xia Z, Chen L. Comprehensive Analysis of Innate Immunophenotyping Based on Immune Score Predicting Immune Alterations and Prognosis in Breast Cancer Patients. Genes. 2022; 13(1):88. https://doi.org/10.3390/genes13010088

Chicago/Turabian Style

Liu, Weiguang, Lingling Xia, Zhengmiao Xia, and Liming Chen. 2022. "Comprehensive Analysis of Innate Immunophenotyping Based on Immune Score Predicting Immune Alterations and Prognosis in Breast Cancer Patients" Genes 13, no. 1: 88. https://doi.org/10.3390/genes13010088

APA Style

Liu, W., Xia, L., Xia, Z., & Chen, L. (2022). Comprehensive Analysis of Innate Immunophenotyping Based on Immune Score Predicting Immune Alterations and Prognosis in Breast Cancer Patients. Genes, 13(1), 88. https://doi.org/10.3390/genes13010088

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