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Article

Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs

1
Laboklin GmbH&Co.KG, Steubenstraße 4, 97688 Bad Kissingen, Germany
2
Institute of Experimental Biomedicine, University Hospital Wuerzburg, 97074 Würzburg, Germany
3
Institute of Genetics, Vetsuisse Faculty, University of Bern, 3001 Bern, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Benjamin N. Sacks
Genes 2021, 12(7), 1092; https://doi.org/10.3390/genes12071092
Received: 30 June 2021 / Revised: 12 July 2021 / Accepted: 13 July 2021 / Published: 19 July 2021
(This article belongs to the Special Issue Canine Genetics 2)
A nonsense variant in HPS3, c.2420G>A or p.Trp807*, was recently discovered as the cause for a brown coat color termed cocoa in French Bulldogs. Here, we studied the genotype–phenotype correlation regarding coat color in HPS3 mutant dogs that carried various combinations of mutant alleles at other coat color genes. Different combinations of HPS3, MLPH and TYRP1 genotypes resulted in subtly different shades of brown coat colors. As HPS3 variants in humans cause the Hermansky–Pudlak syndrome type 3, which in addition to oculocutaneous albinism is characterized by a storage pool deficiency leading to bleeding tendency, we also investigated the phenotypic consequences of the HPS3 variant in French Bulldogs on hematological parameters. HPS3 mutant dogs had a significantly lowered platelet dense granules abundance. However, no increased bleeding tendencies in daily routine were reported by dog owners. We therefore conclude that in dogs, the phenotypic effect of the HPS3 variant is largely restricted to pigmentation. While an effect on platelet morphology is evident, we did not obtain any indications for major health problems associated with the cocoa coat color in French Bulldogs. Further studies will be necessary to definitely rule out very subtle effects on visual acuity or a clinically relevant bleeding disorder. View Full-Text
Keywords: Canis lupus familiaris; dog; thrombocyte; pigmentation; hematology; platelet Canis lupus familiaris; dog; thrombocyte; pigmentation; hematology; platelet
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MDPI and ACS Style

Laukner, A.; Truchet, L.; Manukjan, G.; Schulze, H.; Langbein-Detsch, I.; Mueller, E.; Leeb, T.; Kehl, A. Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs. Genes 2021, 12, 1092. https://doi.org/10.3390/genes12071092

AMA Style

Laukner A, Truchet L, Manukjan G, Schulze H, Langbein-Detsch I, Mueller E, Leeb T, Kehl A. Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs. Genes. 2021; 12(7):1092. https://doi.org/10.3390/genes12071092

Chicago/Turabian Style

Laukner, Anna, Laura Truchet, Georgi Manukjan, Harald Schulze, Ines Langbein-Detsch, Elisabeth Mueller, Tosso Leeb, and Alexandra Kehl. 2021. "Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs" Genes 12, no. 7: 1092. https://doi.org/10.3390/genes12071092

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