Next Article in Journal
Clinical Evidence for the Importance of the Wild-Type PRPF31 Allele in the Phenotypic Expression of RP11
Previous Article in Journal
Adropin Slightly Modulates Lipolysis, Lipogenesis and Expression of Adipokines but Not Glucose Uptake in Rodent Adipocytes
Previous Article in Special Issue
ALDH2 p.E504K Variation and Sex Are Major Factors Associated with Current and Quitting Alcohol Drinking in Japanese Oldest Old

Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

by 1,†, 2,†, 3, 2, 2, 4, 4 and 2,*
Bayannur Hospital, Bayannur 015000, China
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Translational Medical Center, Weifang Second People’s Hospital, The Second Affiliated Hospital of Weifang Medical University, Weifang 261041, China
School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China
Author to whom correspondence should be addressed.
Equal contribution to this work.
Academic Editors: Karen Mather and Selvarangan Ponnazhagan
Genes 2021, 12(6), 913;
Received: 22 April 2021 / Revised: 31 May 2021 / Accepted: 10 June 2021 / Published: 13 June 2021
(This article belongs to the Special Issue Genetic and Environmental Factors in Ageing and Age-Related Disease)
Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets. View Full-Text
Keywords: formaldehyde; epigenetics; age-related cognitive impairment; methylation; demethylation; genotoxin; Alzheimer’s disease formaldehyde; epigenetics; age-related cognitive impairment; methylation; demethylation; genotoxin; Alzheimer’s disease
Show Figures

Figure 1

MDPI and ACS Style

Li, T.; Wei, Y.; Qu, M.; Mou, L.; Miao, J.; Xi, M.; Liu, Y.; He, R. Formaldehyde and De/Methylation in Age-Related Cognitive Impairment. Genes 2021, 12, 913.

AMA Style

Li T, Wei Y, Qu M, Mou L, Miao J, Xi M, Liu Y, He R. Formaldehyde and De/Methylation in Age-Related Cognitive Impairment. Genes. 2021; 12(6):913.

Chicago/Turabian Style

Li, Ting, Yan Wei, Meihua Qu, Lixian Mou, Junye Miao, Mengqi Xi, Ying Liu, and Rongqiao He. 2021. "Formaldehyde and De/Methylation in Age-Related Cognitive Impairment" Genes 12, no. 6: 913.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop