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Formaldehyde and De/Methylation in Age-Related Cognitive Impairment

by 1,†, 2,†, 3, 2, 2, 4, 4 and 2,*
1
Bayannur Hospital, Bayannur 015000, China
2
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
3
Translational Medical Center, Weifang Second People’s Hospital, The Second Affiliated Hospital of Weifang Medical University, Weifang 261041, China
4
School of Life Sciences, Beijing University of Chinese Medicine, Beijing 102488, China
*
Author to whom correspondence should be addressed.
Equal contribution to this work.
Academic Editors: Karen Mather and Selvarangan Ponnazhagan
Genes 2021, 12(6), 913; https://doi.org/10.3390/genes12060913
Received: 22 April 2021 / Revised: 31 May 2021 / Accepted: 10 June 2021 / Published: 13 June 2021
(This article belongs to the Special Issue Genetic and Environmental Factors in Ageing and Age-Related Disease)
Formaldehyde (FA) is a highly reactive substance that is ubiquitous in the environment and is usually considered as a pollutant. In the human body, FA is a product of various metabolic pathways and participates in one-carbon cycle, which provides carbon for the synthesis and modification of bio-compounds, such as DNA, RNA, and amino acids. Endogenous FA plays a role in epigenetic regulation, especially in the methylation and demethylation of DNA, histones, and RNA. Recently, epigenetic alterations associated with FA dysmetabolism have been considered as one of the important features in age-related cognitive impairment (ARCI), suggesting the potential of using FA as a diagnostic biomarker of ARCI. Notably, FA plays multifaceted roles, and, at certain concentrations, it promotes cell proliferation, enhances memory formation, and elongates life span, effects that could also be involved in the aetiology of ARCI. Further investigation of and the regulation of the epigenetics landscape may provide new insights about the aetiology of ARCI and provide novel therapeutic targets. View Full-Text
Keywords: formaldehyde; epigenetics; age-related cognitive impairment; methylation; demethylation; genotoxin; Alzheimer’s disease formaldehyde; epigenetics; age-related cognitive impairment; methylation; demethylation; genotoxin; Alzheimer’s disease
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MDPI and ACS Style

Li, T.; Wei, Y.; Qu, M.; Mou, L.; Miao, J.; Xi, M.; Liu, Y.; He, R. Formaldehyde and De/Methylation in Age-Related Cognitive Impairment. Genes 2021, 12, 913. https://doi.org/10.3390/genes12060913

AMA Style

Li T, Wei Y, Qu M, Mou L, Miao J, Xi M, Liu Y, He R. Formaldehyde and De/Methylation in Age-Related Cognitive Impairment. Genes. 2021; 12(6):913. https://doi.org/10.3390/genes12060913

Chicago/Turabian Style

Li, Ting, Yan Wei, Meihua Qu, Lixian Mou, Junye Miao, Mengqi Xi, Ying Liu, and Rongqiao He. 2021. "Formaldehyde and De/Methylation in Age-Related Cognitive Impairment" Genes 12, no. 6: 913. https://doi.org/10.3390/genes12060913

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