Next Article in Journal
New Bird Sexing Strategy Developed in the Order Psittaciformes Involves Multiple Markers to Avoid Sex Misidentification: Debunked Myth of the Universal DNA Marker
Previous Article in Journal
The Diagnostic Journey of a Patient with Prader–Willi-Like Syndrome and a Unique Homozygous SNURF-SNRPN Variant; Bio-Molecular Analysis and Review of the Literature
Previous Article in Special Issue
The Effect of Genetic Polymorphism in Response to Body Weight Reduction in Japanese Patients with Nonalcoholic Fatty Liver Disease
 
 
Article

High SGO2 Expression Predicts Poor Overall Survival: A Potential Therapeutic Target for Hepatocellular Carcinoma

by 1,2,3,†, 1,2,3,†, 1,2,3, 1,2,3, 1,2,3, 1,2,3 and 1,2,3,*
1
Department of Hepatobiliary Oncology, Sun Yat-sen University Cancer Center, Guangzhou 510060, China
2
State Key Laboratory of Oncology in South China, Guangzhou 510060, China
3
Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China
*
Author to whom correspondence should be addressed.
These authors have contributed equally to this work.
Academic Editor: Hirokazu Takahashi
Genes 2021, 12(6), 876; https://doi.org/10.3390/genes12060876
Received: 11 April 2021 / Revised: 29 May 2021 / Accepted: 3 June 2021 / Published: 7 June 2021
(This article belongs to the Special Issue Genetics and Genomics of Liver Disease)
Shugoshin2 (SGO2) may participate in the occurrence and development of tumors by regulating abnormal cell cycle division, but its prognostic value in hepatocellular carcinoma (HCC) remains unclear. In this study, we accessed The Cancer Genome Atlas (TCGA) database to get the clinical data and gene expression profile of HCC. The expression of SGO2 in HCC tissues and nontumor tissues and the relationship between SGO2 expression, survival, and clinicopathological parameters were analyzed. The SGO2 expression level was significantly higher in HCC tissues than in nontumor tissues (p < 0.001). An analysis from the Oncomine and Gene Expression Profiling Interactive Analysis 2 (GEPIA2) databases also demonstrated that SGO2 was upregulated in HCC (all p < 0.001). A logistic regression analysis revealed that the high expression of SGO2 was significantly correlated with gender, tumor grade, pathological stage, T classification, and Eastern Cancer Oncology Group (ECOG) score (all p < 0.05). The overall survival (OS) of HCC patients with higher SGO2 expression was significantly poor (p < 0.001). A multivariate analysis showed that age and high expression of SGO2 were independent predictors of poor overall survival (all p < 0.05). Twelve signaling pathways were significantly enriched in samples with the high-SGO2 expression phenotype. Ten proteins and 34 genes were significantly correlated with SGO2. In conclusion, the expression of SGO2 is closely related to the survival of HCC. It may be used as a potential therapeutic target and prognostic marker of HCC. View Full-Text
Keywords: SGO2; hepatocellular carcinoma; outcome; survival; therapeutic target; bioinformatics SGO2; hepatocellular carcinoma; outcome; survival; therapeutic target; bioinformatics
Show Figures

Figure 1

MDPI and ACS Style

Deng, M.; Li, S.; Mei, J.; Lin, W.; Zou, J.; Wei, W.; Guo, R. High SGO2 Expression Predicts Poor Overall Survival: A Potential Therapeutic Target for Hepatocellular Carcinoma. Genes 2021, 12, 876. https://doi.org/10.3390/genes12060876

AMA Style

Deng M, Li S, Mei J, Lin W, Zou J, Wei W, Guo R. High SGO2 Expression Predicts Poor Overall Survival: A Potential Therapeutic Target for Hepatocellular Carcinoma. Genes. 2021; 12(6):876. https://doi.org/10.3390/genes12060876

Chicago/Turabian Style

Deng, Min, Shaohua Li, Jie Mei, Wenping Lin, Jingwen Zou, Wei Wei, and Rongping Guo. 2021. "High SGO2 Expression Predicts Poor Overall Survival: A Potential Therapeutic Target for Hepatocellular Carcinoma" Genes 12, no. 6: 876. https://doi.org/10.3390/genes12060876

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop