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Open AccessArticle

Shared Ancestry and Signatures of Recent Selection in Gotland Sheep

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Department of Animal Science, University College of Agriculture and Natural Resources, University of Tehran, Karaj 31587-11167, Iran
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Animal Breeding and Genomics, Wageningen University and Research, P.O. Box 338, 6700 AH Wageningen, The Netherlands
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Department of Animal Science, Faculty of Agriculture and Natural Resources, Islamic Azad University, Tabriz Branch, Tabriz 5157944533, Iran
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Department of Animal Science and Aquaculture, Dalhousie University, Truro, NS B2N5E3, Canada
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L.K. Ernst Federal Research Center for Animal Husbandry, 142132 Podolsk, Russia
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Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, SE-75007 Uppsala, Sweden
*
Author to whom correspondence should be addressed.
Academic Editor: Huitong Zhou
Genes 2021, 12(3), 433; https://doi.org/10.3390/genes12030433
Received: 11 February 2021 / Revised: 1 March 2021 / Accepted: 10 March 2021 / Published: 17 March 2021
(This article belongs to the Section Animal Genetics and Genomics)
Gotland sheep, a breed native to Gotland, Sweden (an island in the Baltic Sea), split from the Gute sheep breed approximately 100 years ago, and since, has probably been crossed with other breeds. This breed has recently gained popularity, due to its pelt quality. This study estimates the shared ancestors and identifies recent selection signatures in Gotland sheep using 600 K single nucleotide polymorphism (SNP) genotype data. Admixture analysis shows that the Gotland sheep is a distinct breed, but also has shared ancestral genomic components with Gute (~50%), Karakul (~30%), Romanov (~20%), and Fjällnäs (~10%) sheep breeds. Two complementary methods were applied to detect selection signatures: A Bayesian population differentiation FST and an integrated haplotype homozygosity score (iHS). Our results find that seven significant SNPs (q-value < 0.05) using the FST analysis and 55 significant SNPs (p-value < 0.0001) using the iHS analysis. Of the candidate genes that contain significant markers, or are in proximity to them, we identify several belongings to the keratin genes, RXFP2, ADCY1, ENOX1, USF2, COX7A1, ARHGAP28, CRYBB2, CAPNS1, FMO3, and GREB1. These genes are involved in wool quality, polled and horned phenotypes, fertility, twining rate, meat quality, and growth traits. In summary, our results provide shared founders of Gotland sheep and insight into genomic regions maintained under selection after the breed was formed. These results contribute to the detection of candidate genes and QTLs underlying economic traits in sheep. View Full-Text
Keywords: Gotland sheep; population structure; pelt quality; selection signatures; BayeScan Gotland sheep; population structure; pelt quality; selection signatures; BayeScan
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MDPI and ACS Style

Ghoreishifar, S.M.; Rochus, C.M.; Moghaddaszadeh-Ahrabi, S.; Davoudi, P.; Salek Ardestani, S.; Zinovieva, N.A.; Deniskova, T.E.; Johansson, A.M. Shared Ancestry and Signatures of Recent Selection in Gotland Sheep. Genes 2021, 12, 433. https://doi.org/10.3390/genes12030433

AMA Style

Ghoreishifar SM, Rochus CM, Moghaddaszadeh-Ahrabi S, Davoudi P, Salek Ardestani S, Zinovieva NA, Deniskova TE, Johansson AM. Shared Ancestry and Signatures of Recent Selection in Gotland Sheep. Genes. 2021; 12(3):433. https://doi.org/10.3390/genes12030433

Chicago/Turabian Style

Ghoreishifar, Seyed M.; Rochus, Christina M.; Moghaddaszadeh-Ahrabi, Sima; Davoudi, Pourya; Salek Ardestani, Siavash; Zinovieva, Natalia A.; Deniskova, Tatiana E.; Johansson, Anna M. 2021. "Shared Ancestry and Signatures of Recent Selection in Gotland Sheep" Genes 12, no. 3: 433. https://doi.org/10.3390/genes12030433

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