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Analysis of RNA Modifications by Second- and Third-Generation Deep Sequencing: 2020 Update

The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?

Centre for Anatomy & Cell Biology, Division of Cell-and Developmental Biology, Medical University of Vienna, Schwarzspanierstrasse 17, Haus C, 1st Floor, 1090 Vienna, Austria
Academic Editors: Stefanie Kellner, Carine Tisne and Pierre Barraud
Genes 2021, 12(3), 345;
Received: 11 January 2021 / Revised: 22 February 2021 / Accepted: 24 February 2021 / Published: 26 February 2021
(This article belongs to the Special Issue Functions and Dynamics of RNA Modifications)
RNA modifications, long considered to be molecular curiosities embellishing just abundant and non-coding RNAs, have now moved into the focus of both academic and applied research. Dedicated research efforts (epitranscriptomics) aim at deciphering the underlying principles by determining RNA modification landscapes and investigating the molecular mechanisms that establish, interpret and modulate the information potential of RNA beyond the combination of four canonical nucleotides. This has resulted in mapping various epitranscriptomes at high resolution and in cataloguing the effects caused by aberrant RNA modification circuitry. While the scope of the obtained insights has been complex and exciting, most of current epitranscriptomics appears to be stuck in the process of producing data, with very few efforts to disentangle cause from consequence when studying a specific RNA modification system. This article discusses various knowledge gaps in this field with the aim to raise one specific question: how are the enzymes regulated that dynamically install and modify RNA modifications? Furthermore, various technologies will be highlighted whose development and use might allow identifying specific and context-dependent regulators of epitranscriptomic mechanisms. Given the complexity of individual epitranscriptomes, determining their regulatory principles will become crucially important, especially when aiming at modifying specific aspects of an epitranscriptome both for experimental and, potentially, therapeutic purposes. View Full-Text
Keywords: epitranscriptomics; regulation; reproducibility epitranscriptomics; regulation; reproducibility
MDPI and ACS Style

Schaefer, M.R. The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics? Genes 2021, 12, 345.

AMA Style

Schaefer MR. The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics? Genes. 2021; 12(3):345.

Chicago/Turabian Style

Schaefer, Matthias R. 2021. "The Regulation of RNA Modification Systems: The Next Frontier in Epitranscriptomics?" Genes 12, no. 3: 345.

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